Voltage-Gated Ion Channels Iii

Front 1

Na+ Channels
(Depolarization/Hyperpolarization)

Back 1

Depolarization

Front 2

K+ Channels
(Depolarization/Hyperpolarization)

Back 2

Hyperpolarization

Front 3

Cl- Channels
(Depolarization/Hyperpolarization)

Back 3

Hyperpolarization

Front 4

Ca2+ Channels
(Depolarization/Hyperpolarization)

Back 4

Depolarization

Front 5

Chloride is going to generate an _______ current and cause _________ of membrane potential.

Back 5

Inward
Hyperpolarization

Front 6

Potassium is going to generate an _________ current and cause __________ of the membrane potential.

Back 6

Outward
Hyperpolarization

Front 7

Voltage-Dependent K+ Channels

Back 7

IA
ID
IK
IM

Front 8

Rectifier K+ Channels

Back 8

IK
Anomalous
IH
Tandem Pore

Front 9

Metabotropic-gated K+ Channels

Back 9

IM
IATP
IAHP
IsAHP

Front 10

Calcium-dependent K+

Back 10

IC
IM
IAHP
IsAHP

Front 11

VDKCs:
IA Channel
(HVA/LVA)
(FI/SI/NI)

Back 11

LVA
FI

Front 12

VDKCs:
ID Channel
(HVA/LVA)
(FI/SI/NI)

Back 12

LVA
FI

Front 13

VDKCs:
IK Channel
(HVA/LVA)
(FI/SI/NI)

Back 13

HVA
SI

Front 14

VDKCs:
IM Channel
(HVA/LVA)
(FI/SI/NI)

Back 14

LVA
NI

Front 15

Voltage-Dependent conformational movement of negatively charged portions of the alpha subunit ___________ K+ influx.

Back 15

Activates

Front 16

Inactivation involves voltage-dependent binding of any 1 of 4 positively charged "ball and chain" portion of th beta subunit to ______ K+ influx.

Back 16

Block

Front 17

The IM channel lacks the ________ subunit thus it is non-inactivating.

Back 17

Beta

Front 18

The anomalous rectifier and the IH(Q) channels contain ______ separate subunits with _______ transmembrane segments.

Back 18

Four
Two

Front 19

The tandem pore channels contain _______ subunits with ________ transmembrane segments, these transmembrane segments come together as sets of four and along with another set of four. The dimerize together and form ______ pores.

Back 19

Four
Four
Two

Front 20

Rectifying Channels:
IK Channel
(HVA/HA/LVA)
(FI/SI/NI)

Back 20

HVA
SI

Front 21

Rectifying Channels:
Anomalous Channel
(HVA/HA/LVA)
(FI/SI/NI)

Back 21

HA
SI

Front 22

Rectifying Channels:
IH(Q) Channel
(HVA/HA/LVA)
(FI/SI/NI)

Back 22

HA
SI

Front 23

Rectifying Channels:
Tandem Pore Channel
(HVA/HA/LVA)
(FI/SI/NI)

Back 23

SI

Front 24

The anomalous rectifier and the IH(Q) channels ate going to generate an _________ current of potassium and cause _________ of the membrane potential.

Back 24

Inward
Depolarizationn

Front 25

Volatile Anesthetics tend to turn on the ________ channels.

Back 25

Tandem Pore

Front 26

CaM is the Ca2+ sensor for the _______ channels.

Back 26

IAHP

Front 27

CaM remains bound to the AHP channels even when theres is not any Ca2+ bound to CaM. This is known as ________ binding.

Back 27

Constitutive

Front 28

What is the toxin which will bind to the extracellular face of the SK-channels and prevent K+ ions from flowing out of them?

Back 28

Apamin

Front 29

Hippocalcin is a CBP that is going to act as a calcium sensor for the ______ channels.

Back 29

sAHP

Front 30

Hippocalcin is not as sensitive to calcium as CaM, it is going to bind _______ calcium as opposed to four.

Back 30

Three

Front 31

True or False:
Hippocalcin remains constitutively bound to the sAHP channels.

Back 31

False.

Front 32

CDKCs:
IM channels
(Fast-AHP/Medium-AHP/Slow-AHP/Not Applicable)

Back 32

N/A

Front 33

CDKCs:
IC channels
(Fast-AHP/Medium-AHP/Slow-AHP/Not Applicable)

Back 33

Fast-AHP

Front 34

CDKCs:
IAHP
(Fast-AHP/Medium-AHP/Slow-AHP/Not Applicable)

Back 34

Medium-AHP

Front 35

CDKCs:
IsAHP
(Fast-AHP/Medium-AHP/Slow-AHP/Not Applicable)

Back 35

Slow-AHP

Front 36

CDKCs:
IAHP channels
(CaM/Hippocalcin)

Back 36

CaM

Front 37

CDKCs:
IsAHP channels
(CaM/Hippocalcin)

Back 37

Hippocalcin

Front 38

CDKCs:
IM channels
(FI/SI/NI)

Back 38

SI

Front 39

CDKCs:
IC channels
(FI/SI/NI)

Back 39

FI

Front 40

CDKCs:
IAHP channels
(FI/SI/NI)

Back 40

NI

Front 41

CDKCs:
IsAHP channels
(FI/SI/NI)

Back 41

NI

Front 42

Chlorotoxin

Back 42

Cl- channels

Front 43

Retigabine

Back 43

IA channels
IM channels

Front 44

DTX

Back 44

IA channels
ID channels
IK channels

Front 45

Halothane

Back 45

Tandem pore channels

Front 46

Isoflurane

Back 46

Tandem pore channels

Front 47

Acetylcholine

Back 47

IM channels

Front 48

ATP

Back 48

IATP channels

Front 49

Apamin

Back 49

IAHP channels

Front 50

Niflumate

Back 50

IC channels

Front 51

Tamoxifen

Back 51

Cl- channels

Front 52

Minoxidil

Back 52

ID channels

Front 53

Cesium Ions

Back 53

IA channels
ID channels
IK channels
IM channels
Anomalous channels
IH(Q) channels

Front 54

Linopiridine

Back 54

IM channels

Front 55

Dequalinium

Back 55

IAHP channels

Front 56

Charybdotoxin

Back 56

IC channels

Front 57

Calcium Ions

Back 57

IAHP channels
IsAHP channels