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6 Cards in this Set

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Vitamin K

Discovered by Henrik Dam


crucial role in blood clotting


K for "koagulation"

Vitamin K - Forms

Family of compounds known as Quinones




Phylloquinone: K1, form from plant sources




Menaquinones: K2, Animal Sources; also produced by intestinal bacteria




Menadione: K3, Medicinal form of Vit K that can be toxic to infants

Vitamin K - Functions

Blood clotting


-Production of proteins


-Require calcium for activation


-Cancium binding capacity allows for change




Bone Formation


Osteocalcin: Imp. to carboxylation of osteocalcin



Low Vit K associated w/ age-related bone loss

Vitamin K - Sources

2 sources: food and bacteria living in our colons


Small intestine absorbs vit K


Colon absorbs vit K made by bacteria




Veggies: Spinach, turnip greens, broccoli


Veggie oils: soybean, canola, olive




Exposure to light degrades vit K

Vitamin K - Deficiency

Rare in healthy adults


Typical diets supplying less than optimal amounts.


Lower bone density in women.


Increases risk of fractures, hemorrhage




People who suffer w/ fat-malabsorption syndrome




Megadoses of vit A & E counteract actions of Vit K




Newborn babes (breastfed) run risk of vit K defic bc at birth they lack intestinal bacteria that produce the nutrient

Vitamin K - Toxicity

Rare from food




No set UL




Overdose can cause hemolytic anemia


can interfere w/ anticoagulant meds.


can occur w/ newborns who receive vit K in form of menadione rather than recommended form, phylloquinone.