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19 Cards in this Set
- Front
- Back
List the following characteristics of Poxviridae:
genome structure important viruses |
linear ds DNA
envelope, brick-shaped complex variola, vaccinia, molluscum, contagiosum |
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List the different viruses in the Herpesviridae family.
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HHV1 = HVS1 = cold sores
HHV2 = HSV2 = genital sores HHV3 = varicella-zoster = chicken pox HHV4 = cytomegalovirus HHV5 = epstein-barr virus = mononucleosis HHV6 = roseola infantum HHV7 = no disease HHV8 = Kaposi's sarcoma Herpes B = encephalitis |
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What is the genomic and morphological structure of Herpesviridae?
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linear ds DNA
envelope icosahedron |
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How do Herpesviridae replicate?
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1. viral genome enters nucleus via nuclear pore
2. tegument proteins direct cell RNA polymerase to transcribe immediate-early (IE) viral genes (DNA-->RNA) 3. IE mRNA translated (RNA-->Protein) to produce enzymes for viral DNA replication 4. viral DNA replicates using viral enzymes 5. DNA includes L gene which is transcribed and translated 6. DNA is also stored for viral progeny packaging 7. L gene gives rise to structural proteins and glycoproteins 8. viral progeny exit nucleus and acquire envelope by budding through nuclear membrane |
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Herpes symplex viruses are part of what group of Herpesviridae?
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alphaherpesvirus - broad host range, lytic in culture, neurotropic, short life cycle
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How is shingles acquired?
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Reactivation of varicella-zoster virus - can be caused by loss of immunity or immunocompromised state
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Where does the varicella-zoster virus tend to replicate?
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primary viremia - replication in regional lymph nodes, liver, spleen
secondary viremia - replication in epidermal cells |
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Where might you find latent cytomegalovirus?
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cells of monocytic lineage
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Where might you find latent epstein-barr virus?
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B lymphocytes
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What kind of cancers can be caused by epstein-barr virus?
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Burkitt's lymphoma
nasopharygeal carcinoma B cell lymphoma |
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What causes pathology in epstein-barr virus?
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B cells are infected via interaction of CD21 and MHCII, leading to B cell expression of viral proteins EBNA1, LMP1, LMP2, which induces an immune response by T cells. T cells quickly kill B cells that express these viral proteins, causing a release of cytokines. Release of cytokines is what causes the symptoms experienced.
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HHV8 is part of what group of Herpesviridae?
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gammaherpesvirus - lymphotropic
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List the following characteristics of Adenoviridae:
genome structure important viruses receptors |
linear ds DNA
naked, icosahedral adenovirus coxsackie B3 receptor, integrins |
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List the following characteristics of Parvoviridae:
genome structure |
linear ss DNA
naked icosahedral |
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List the following characteristics of Papovaviridae:
genome structure important viruses |
circular ss DNA
naked, icosahedral Papillomavirus, Polyomavirus |
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What serotypes of papillomavirus are associated with cervical cancer?
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16
18 31 |
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What viral proteins are required for proliferation of papillomavirus?
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E6 - binds to and degrades p53
E7 - binds to RB and prevents its natural activities |
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What is papillomavirus's mode of infection?
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initially infects epithelial cells
then induces proliferation of cells in basal layer by expressing a subset of viral genes infected cells differentiate and move to surface of wart where viral progeny are produced |
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What virus has a circular ds DNA genome and an envelope?
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Baculoviridae
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