Viruses

Front 1

Papovaviridae

1)NUCLEIC ACID Type
2)ENVELOPE?
3)SHAPE
4)DNA REPLICATES IN:
5)MAJOR VIRUSES

Back 1

1)ds-DNA, circular

2)Naked

3)icosahedral

4)nucleus

5)HPV
BK Polyomavirus
JC Polyomacirus

Front 2

POXVIRIDAE

1)NUCLEIC ACID Type
2)ENVELOPE?
3)SHAPE
4)DNA REPLICATES IN:
5)MAJOR VIRUSES

Back 2

1)DS-DNA, linear

2)enveloped (makes its own)

3)brick-shaped complex

4)cytoplasm

5)variola/ smallpox
vaccinia
molluscum
contagiosum

Front 3

ADENOVIRIDAE

1)NUCLEIC ACID Type
2)ENVELOPE?
3)SHAPE
4)DNA REPLICATES IN:
5)MAJOR VIRUSES

Back 3

1)ds-DNA, linear

2)naked

3)icosahedral

4)nucleus

5)Adenovirus

Front 4

HERPES VIRUS

1)NUCLEIC ACID Type
2)ENVELOPE?
3)SHAPE
4)DNA REPLICATES IN:
5)MAJOR VIRUSES

Back 4

1)ds-DNA, linear

2)enveloped (nuclear)

3) icosahedral

4) nucleus

5)HSV
Varicella-Zoster
Epstein-Barr
CMV

Front 5

HEPADNAVIRIDAE

1)NUCLEIC ACID Type
2)ENVELOPE?
3)SHAPE
4)DNA REPLICATES IN:
5)MAJOR VIRUSES

Back 5

1)dsDNA, circular

2)enveloped

3)icosahedral

4)nucleus

5)Hepatitis B

Front 6

PARVOVIRIDAE

1)NUCLEIC ACID Type
2)ENVELOPE?
3)SHAPE
4)DNA REPLICATES IN:
5)MAJOR VIRUSES

Back 6

1)ssDNA

2)naked

3)icossahedral

4)nucleus

5)B19

Front 7

HEPADNAVIRIDAE

1)NUCLEIC ACID Type
2)ENVELOPE?
3)SHAPE
4)DNA REPLICATES IN:
5)MAJOR VIRUSES

Back 7

1)dsDNA, circular

2)enveloped

3)icosahedral

4)nucleus

5)Hepatitis B

Front 8

HPV
1)Serotypes
2)epidemiology
3)Transmission
4)pathogenesis
5)clinical symptoms
6)pathology/diagnosis
7)immunity
8)treatment
9)prevention

Back 8

1)70 serotypes

2)condyloma acuminatum (oranogenital warts)=most common STD in US
93% of cervical cancers have HPV DNA--types 16, 18, 31, or 45)

3)direct contact, trauma, maternal-fetal at time of birth

4)--

5)skin=HPV 1-4; genital=HPV 6-11; carcinoma penis/cervix=HPV 16,18,31,45

--Early genes supress p53, Rb and are carcinogenic (E6, E7)

6)path=koilocytes (cytoplasmic vacuole)

7)--
8)cutettage, cryosurgery, electrosurgery, topical agents

9)STD counseling

Front 9

BK Virus

1)Serotypes
2)epidemiology
3)Transmission
4)pathogenesis
5)clinical symptoms
6)pathology/diagnosis
7)immunity
8)treatment
9)prevention

Back 9

1)--

2)Occurs in 45% of renal transplantees, 50% BMT patients

3)close contact, clinical latency, viral shedding in urine

4)--

5)hemorrhagic cystitis & urethral stenosis in immunocompromised.
Involved in kidney transplant rejection (allograph nephropathy)
--primary inf=mild URI in 1/3, rest are asymptomatic

6)cytological exam of urinary epithelial cells
--PCR

7)60-80% of western adults have Ab's
BKV acquired by 3-4 yrs of age

8)supportive therapy
-aggressive immune improvement (HAART for HIV pts etc)
-interferon
-Cidofovir

Front 10

JC Virus
--------------
1)Serotypes
2)epidemiology
3)Transmission
4)pathogenesis
5)clinical symptoms
6)pathology/diagnosis
7)immunity
8)treatment
9)prevention

Back 10

1)--

2)50% assoc with HIV (1-4% HIV pts develop PML)

3)close contact, clinical latency

4)--

5)primary inf--asymptomatic
--latent period, resides in kidneys and CNS mononuclear cells

-PML=prog.multifocal leukoencephalopathy
damages oligodendrocytes in ICH, signs of inc ICP, and death w/in 6mo

6)giant astrocytes with intranuclear inclusions
DX=cytology, brain biopsy,
PCR, CSF

mononuclear cells in CNS & oligodendrocytes

7)60-80% of western adults have Abs-dz occurs when latent JCV activated in ICH

8)improve immune status, supportive
therapy (cidofovir may help)

Front 11

Variola virus/smallpox
---------------
1)Serotypes
2)epidemiology
3)Transmission
4)pathogenesis
5)clinical symptoms
6)pathology/diagnosis
7)immunity
8)treatment
9)prevention

Back 11

1)1

2)

3)aerosol, direct contact with skin lesions or fomites

4)respiratory tract-->LN-->viremia-->organs-->viremia-->skin

ENTRY: mucous membrane of resp tract

-contains a virion polymerase b/c only DNA virus that replicates in cytoplasm

5)7-17 days incubation period
PRODROME-mouth,pharynx 2-3days-30% fatal
--severe headache, backache, fever
--fever goes away afer 3 days
--enanthema over tongue, mouth & rash

6)DX=PCR swab
**ALL vesicles at same stage of dev. unlike chicken pox

7)T & B cells upon infection, Abs in a week (lifelong)

8)Isolation, topical care of lesions, maybe Cidofovir

9)smallpox vaccine

Front 12

Human Retroviruses

Back 12

*HIV 1 and 2

Front 13

Structure of Retroviruses

Back 13

*have 2 identical strands of single stranded linear RNA…therefore, diploid

Front 14

HIV entry into host cells

Back 14

*gp120 attaches to CD4+ receptors on Tcells & macrophages

Front 15

Retroviral Replication

Back 15

*comes w/ its own reverse transcriptase

Front 16

gag or env genes

Back 16

*gag encoes for structure

Front 17

HIV-1 Diagnosis

Back 17

*Serology: ELISA & Western Blot

Front 18

HIV -2

Back 18

*40% similar to HIV-1

Front 19

HTLV-1 and HTLV-2

Back 19

*they are oncoviruses

Front 20

1)Serotypes

2)epidemiology

3)Transmission

4)pathogenesis

5)clinical symptoms

6)pathology/diagnosis

7)immunity

8)treatment

9)prevention

Back 20

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