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20 Cards in this Set

  • Front
  • Back
Papovaviridae

1)NUCLEIC ACID Type
2)ENVELOPE?
3)SHAPE
4)DNA REPLICATES IN:
5)MAJOR VIRUSES
1)ds-DNA, circular

2)Naked

3)icosahedral

4)nucleus

5)HPV
BK Polyomavirus
JC Polyomacirus
POXVIRIDAE

1)NUCLEIC ACID Type
2)ENVELOPE?
3)SHAPE
4)DNA REPLICATES IN:
5)MAJOR VIRUSES
1)DS-DNA, linear

2)enveloped (makes its own)

3)brick-shaped complex

4)cytoplasm

5)variola/ smallpox
vaccinia
molluscum
contagiosum
ADENOVIRIDAE

1)NUCLEIC ACID Type
2)ENVELOPE?
3)SHAPE
4)DNA REPLICATES IN:
5)MAJOR VIRUSES
1)ds-DNA, linear

2)naked

3)icosahedral

4)nucleus

5)Adenovirus
HERPES VIRUS

1)NUCLEIC ACID Type
2)ENVELOPE?
3)SHAPE
4)DNA REPLICATES IN:
5)MAJOR VIRUSES
1)ds-DNA, linear

2)enveloped (nuclear)

3) icosahedral

4) nucleus

5)HSV
Varicella-Zoster
Epstein-Barr
CMV
HEPADNAVIRIDAE

1)NUCLEIC ACID Type
2)ENVELOPE?
3)SHAPE
4)DNA REPLICATES IN:
5)MAJOR VIRUSES
1)dsDNA, circular

2)enveloped

3)icosahedral

4)nucleus

5)Hepatitis B
PARVOVIRIDAE

1)NUCLEIC ACID Type
2)ENVELOPE?
3)SHAPE
4)DNA REPLICATES IN:
5)MAJOR VIRUSES
1)ssDNA

2)naked

3)icossahedral

4)nucleus

5)B19
HEPADNAVIRIDAE

1)NUCLEIC ACID Type
2)ENVELOPE?
3)SHAPE
4)DNA REPLICATES IN:
5)MAJOR VIRUSES
1)dsDNA, circular

2)enveloped

3)icosahedral

4)nucleus

5)Hepatitis B
HPV
1)Serotypes
2)epidemiology
3)Transmission
4)pathogenesis
5)clinical symptoms
6)pathology/diagnosis
7)immunity
8)treatment
9)prevention
1)70 serotypes

2)condyloma acuminatum (oranogenital warts)=most common STD in US
93% of cervical cancers have HPV DNA--types 16, 18, 31, or 45)

3)direct contact, trauma, maternal-fetal at time of birth

4)--

5)skin=HPV 1-4; genital=HPV 6-11; carcinoma penis/cervix=HPV 16,18,31,45

--Early genes supress p53, Rb and are carcinogenic (E6, E7)

6)path=koilocytes (cytoplasmic vacuole)

7)--
8)cutettage, cryosurgery, electrosurgery, topical agents

9)STD counseling
BK Virus

1)Serotypes
2)epidemiology
3)Transmission
4)pathogenesis
5)clinical symptoms
6)pathology/diagnosis
7)immunity
8)treatment
9)prevention
1)--

2)Occurs in 45% of renal transplantees, 50% BMT patients

3)close contact, clinical latency, viral shedding in urine

4)--

5)hemorrhagic cystitis & urethral stenosis in immunocompromised.
Involved in kidney transplant rejection (allograph nephropathy)
--primary inf=mild URI in 1/3, rest are asymptomatic

6)cytological exam of urinary epithelial cells
--PCR

7)60-80% of western adults have Ab's
BKV acquired by 3-4 yrs of age

8)supportive therapy
-aggressive immune improvement (HAART for HIV pts etc)
-interferon
-Cidofovir
JC Virus
--------------
1)Serotypes
2)epidemiology
3)Transmission
4)pathogenesis
5)clinical symptoms
6)pathology/diagnosis
7)immunity
8)treatment
9)prevention
1)--

2)50% assoc with HIV (1-4% HIV pts develop PML)

3)close contact, clinical latency

4)--

5)primary inf--asymptomatic
--latent period, resides in kidneys and CNS mononuclear cells

-PML=prog.multifocal leukoencephalopathy
damages oligodendrocytes in ICH, signs of inc ICP, and death w/in 6mo

6)giant astrocytes with intranuclear inclusions
DX=cytology, brain biopsy,
PCR, CSF

mononuclear cells in CNS & oligodendrocytes

7)60-80% of western adults have Abs-dz occurs when latent JCV activated in ICH

8)improve immune status, supportive
therapy (cidofovir may help)
Variola virus/smallpox
---------------
1)Serotypes
2)epidemiology
3)Transmission
4)pathogenesis
5)clinical symptoms
6)pathology/diagnosis
7)immunity
8)treatment
9)prevention
1)1

2)

3)aerosol, direct contact with skin lesions or fomites

4)respiratory tract-->LN-->viremia-->organs-->viremia-->skin

ENTRY: mucous membrane of resp tract

-contains a virion polymerase b/c only DNA virus that replicates in cytoplasm

5)7-17 days incubation period
PRODROME-mouth,pharynx 2-3days-30% fatal
--severe headache, backache, fever
--fever goes away afer 3 days
--enanthema over tongue, mouth & rash

6)DX=PCR swab
**ALL vesicles at same stage of dev. unlike chicken pox

7)T & B cells upon infection, Abs in a week (lifelong)

8)Isolation, topical care of lesions, maybe Cidofovir

9)smallpox vaccine
Human Retroviruses
*HIV 1 and 2
Structure of Retroviruses
*have 2 identical strands of single stranded linear RNA…therefore, diploid
HIV entry into host cells
*gp120 attaches to CD4+ receptors on Tcells & macrophages
Retroviral Replication
*comes w/ its own reverse transcriptase
gag or env genes
*gag encoes for structure
HIV-1 Diagnosis
*Serology: ELISA & Western Blot
HIV -2
*40% similar to HIV-1
HTLV-1 and HTLV-2
*they are oncoviruses
1)Serotypes

2)epidemiology

3)Transmission

4)pathogenesis

5)clinical symptoms

6)pathology/diagnosis

7)immunity

8)treatment

9)prevention
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