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427 Cards in this Set
- Front
- Back
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What disease does Adeno-associated virus cause
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only medical importance in possible gene therapy
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What disease does Adenovirus cause
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#3 common cold cause; acute or latent depending on host cell; resp, conjunctivitis, gastro, febrile pharyngitis
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What disease does Alphaherpesvirinae cause
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HSV 1&2, VZV
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What disease does Alphavirus cause
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mild flu-like, can progress to encephalitis
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What disease does arbovirus cause
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dengue, yellow fever, west nile & st louis encephalitis
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What disease does Arenaviruscause
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zoonotic (robo); LCM, lassa, junin, machupo fevers
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What disease does B19 (fifth disease) Erythema infectiosumcause
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1/5 childhood rashes; must infect replicating cells (erythroid)
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What disease does Betaherpesvirinae cause
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CMV, HHV 6 & 7
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What disease does bird flu cause
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type of Influenza A
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What disease does BK viruscause
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kidney & urinary tract infections
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What disease does Bunyavirus cause
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mild flu-like except: La Crosse, Rift valley, hantaan
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What disease does Calicivirus cause
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see Norwalk-like Virus
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What disease does California encephalitis viruscause
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febrile, encephalitis, rash
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What disease does Cardiovirus cause
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zoonotic
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What disease does Coltivirus cause
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=arbovirus=arthropodborn viremic; persist in RBC -> hemorrhage, encephalitis or acute
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What disease does Coronavirus cause
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#2 cause of common cold, SARS, some URT & gastroenteritis
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What disease does Coxsackievirus Acause
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herpangina; hand foot & mouth; encephalitis, meningitis; carditis, common cold, & more
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What disease does Coxsackievirus Bcause
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pleurodynia, encephalitis, meningitis; carditis, common cold, & more
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What disease does Crimean-Congo hemorrhagic fever viruscause
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What disease does Cytomegalovirus (CMV)cause
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rarely disease in immune competent; heterophile neg mononucleosis; congenital or perinatal (via colostrum) infxn
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What disease does Dengue cause
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hemorrhagic fever/ shock syndrome by reinfxn = hypersensitivity
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What disease does Echoviruscause
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encephalitis, meningitis; carditis, common cold, & more
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What disease does Enterovirus cause
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see polio, coxsackie, & echo
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What disease does Epstein-Barr Virus cause
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infectious mono; Burkitt's Lymphoma; Nasopharyngeal carcinoma
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What disease does Filovirus cause
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Ebola, Marburg other Hemorrhagic fevers
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What disease does Flavivirus cause
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mostly mild except yellow fever, St Louis, west nile, HepC, HepG; SEE pg61 Chart for all diseases (toga&flavi)
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What disease does Foot and mouth disease viruscause
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#NAME?
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What disease does Gammaherpesvirinae cause
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EBV = B cells (&epi); HHV8 = lymphocytes, unknown latent cell type
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What disease does Hantaan virus cause
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pulmonary syndrome = Sin Nombre infects & persists in lungs
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What disease does Hepatitis A (Heparnavirus)cause
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acute, abrupt onset; 1mo incubtn; jaundice, loss of appetite, abdomen pain
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What disease does Hepatitis B (serum hepatitis)cause
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acute (HBcAg) or chronic(HBs, HBeAg); chronic -> cirrhosis or w/ HDV -> fuminate or 80% of 1 hepatocellular carcinoma
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What disease does Hepatitis C cause
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15% acute, 85% chronic; NonA, NonB hepatitis; infxn predisposes to 1 hepatocellular carcinoma
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What disease does Hepatitis D (delta agent)cause
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NonA, NonB hepatitis; ->fulminate & massive necrosis
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What disease does Hepatitis E aka enteric Non A, NonB hepatitiscause
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enteric (like all hep, infect liver -> jaundice & disrupt AST & ALT)
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What disease does Hepatitis Gcause
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NonA, NonB hepatitis
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What disease does Herpes Simplexvirus cause
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herpes labialis oral = cold sores; genital = mostly 2, prodromal tingling; "Hit & Run" cancer
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What disease does Herpesvirus cause
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HHV 1-8; subfamilies: alpha, beta, gammavirinae;
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What disease does HIV-1 cause
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acute->asymptomatic->AIDS->Late stage (REVIEW life cycle steps that are targets for antiviral drugs pg 106)
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What disease does HIV-2 cause
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longer clinical latency& lower morbidity than HIV1& similar to SMM
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What disease does Human Herpesvirus 6 (&7)cause
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no disease of HHV7; 6 = 1/5 childhood rashes, or mild mono in adults
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What disease does Human Herpesvirus 8 (KSV - Kaposi's sarcoma herpes)cause
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Kaposi's = Bcell lymphoma; also causes Castleman's disease
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What disease does Human T-cell leukemia virus (trans-acting retrovirus)cause
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incubation = years; immortalizes Tcells; replication competent
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What disease does Influenza A cause
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#1 viral killer in US; flu-like symptoms
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What disease does Influenza B cause
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see influ A
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What disease does Influenza C cause
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no disease but 95% adults have Abs
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What disease does JC Viruscause
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PML
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What disease does La Crosse virus cause
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encephalitis, fever, lethargy, vomiting, seizures
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What disease does Lentivirus ("slow viruses")cause
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immune deficiencies; see HIV & HTLV
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What disease does Measles /morbillivirus/ rubeolacause
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measles -> pneumonia, encephalitis, subacute sclerosing panencephalitis, CCC&P; atypical if killed vaccine
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What disease does Molluscum Contagiosum cause
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nodules, self-limiting
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What disease does Monkey B Virus cause
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simian version of HSV = risk group 4 agent
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What disease does Monkeypox cause
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similar to smallpox, reappearing due to vaccinia
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What disease does Mumps virus cause
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acute, benign parotits
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What disease does Norwalk-like Virus aka noroviruscause
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viral gastroenteritis (vomiting & diarrhea);
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What disease does Orthomyxoviruscause
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Influenza A,B,C (determine by HA, NA, M1&2 = proteins); lysis of URT epi
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What disease does Papillomavirus cause
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HPVs = warts, cervical carcinoma - depends on type; usually benign, selflimiting
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What disease does Parainfluenza virus cause
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common cold; 1,2,3 -> LRT infxn (croup)
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What disease does Paramyxovirus cause
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see measles, mumps, parainflu, RSV
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What disease does Picornavirus cause
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depends on target organ of various viruses w/in family
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What disease does Poliovirus (entero)cause
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Asymptomatic, abortive, paralytic or non-para poliomyelitis
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What disease does Polyomavirus cause
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BK, PML (progressive focal leukoencephalo.), SV40; not pathogenic in immune competent
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What disease does Reovirus cause
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orthoreovirus = no significant disease
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What disease does Respiratory syncytial virus cause
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fatal acute RT infxn in children; no hemagglutintn of RBCs
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What disease does Retroviruscause
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simple = gag, pol, env, LTR; complex(see HTLV, HIV) = simple + tat, rex
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What disease does Rhabdovirus (rabies = human found virus)cause
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rabies in humans from bite -> encephalitis
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What disease does Rhinovirus cause
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#1 cause of common cold
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What disease does Rift valley fever virus cause
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petechial hemorrahages
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What disease does Rotavirus cause
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AB,C = human; gastroenteritis, blocks H2O readsorption
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What disease does Rubella/Rubivirus cause
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rash, viremic; congenital disease from maternal infxn during pregnancy
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What disease does SARS cause
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severe respiratory illness w/ nonproductive cough & dyspnea
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What disease does Smallpox aka Variolacause
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URT & 2nd viremia->rash; prodromal fever then centrifugal, regular rash
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What disease does Vaccinia (cowpox or Milker's nodules)cause
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zoonotic viruses (also Orf in goats & herders)
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What disease does Varicella cause
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chickenpox 1/5 childhood rashes
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What disease does Varicella-Zoster Viruscause
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chickenpox/varicella 1/5 childhood rashes; shingles = zoster; resp virus & viremic;
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What disease does West Nile Viruscause
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mild, nonspecific unless encephalitis
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What disease does Yellow fever cause
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jaundice &/or black blood (gastro hemorrhages
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What disease does Zoster cause
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shingles in adults
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How is Adeno-associated virus special
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smallest DNA genome
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How is Adenovirus special
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virus E1A, E1B bind host pRB, p53 respectively; tough capsid; humans = only reservoir
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How is Alphaherpesvirinae special
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fast growing, latent in neuronal tissue, wide host & cell range
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How is Alphavirus special
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see PG 61 CHART for all virus/disease names!
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How is arbovirus special
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also sandfly fever virus, venezuelan equine encephalitis,
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How is Arenavirus special
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persistant->induce tolerance, infect Macs, lassa= hemorrhagic; tropical regions
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How is B19 (fifth disease) Erythema infectiosum special
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most adults sero+; resistant naked capsid; shed virus before symptoms; crosses placenta
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How is Betaherpesvirinae special
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slow growing, latency in cells of immune system, slightly restricted host range
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How is bird flu special
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restricted human-human transmission
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How is BK virus special
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only get disease in immunocompromised
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How is Bunyavirus special
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usually foreign to US except california and hantavirus
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How is Calicivirus special
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How is California encephalitis virus special
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mosquito vector, forest rangers, campers, woodsmen
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How is Cardiovirus special
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rodent hosts, but other animals can get it
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How is Coltivirus special
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different from Rocky Mountain = bacteria; also animal reservoir; geographic distribute by arthopod region
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How is Coronavirus special
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helical nucleocapsid w/ glycoproteins for Largest RNA virus; civet cats = host; grows best @low temp;most adults are seropositive
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How is Coxsackievirus A special
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serology possible but difficult; differ strains -> differ disease; infants highest risk;
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How is Coxsackievirus B special
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serology possible but difficult; differ strains -> differ disease; infants highest risk;
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How is Crimean-Congo hemorrhagic fever virus special
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How is Cytomegalovirus (CMV) special
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can be acute, latent &/or persistent at once; significant complictn in transplants; birth defects if mom has 1o infxn during delivery; nuclear inclusion bodies; determine viral load to decide if gancyclovir is worth the risks
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How is Dengue special
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How is Echovirus special
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serology possible but difficult; differ strains -> differ disease; infants highest risk;
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How is Enterovirus special
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replicates in gut, but causes disease elsewhere
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How is Epstein-Barr Virus special
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grows in Bcells- replicates & is latent; attaches via CR2 (CD21) receptors; mono can -> jaundice, enlarged spleen
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How is Filovirus special
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cytolytic viruses causing extensive tissue necrosis; inclusion bodies seen in LM
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How is Flavivirus special
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preferentially infect macs via Fc receptors; bud @ internal membs; cytolytic or immunopathologic
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How is Foot and mouth disease virus special
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can infect humans, but asymptomatic; not in USA
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How is Gammaherpesvirinae special
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slow growing, very restricted host range, oncogenic potential
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How is Hantaan virus special
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leakage of blood thru vasculature of lungs -> pulmonary edema-> failure->death
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How is Hepatitis A (Heparnavirus) special
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shed virus bf & after jaundice appears; often asymptomatic; 40% of acute hepatitis = HAV
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How is Hepatitis B (serum hepatitis) special
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hepatitis from CMI & inflam, not cytopathic; acute: long incubtn, gradual onset; window= time when sAg/Ab can't be detected
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How is Hepatitis C special
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persistent infxn-> PHC; coats itself in LDL or attaches to CD81 surface receptor
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How is Hepatitis D (delta agent) special
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defective virus requiring HBV (chronic HBV then HDV -> superinfected)
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How is Hepatitis E aka enteric Non A, NonB hepatitis special
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like HAV except slower onset w/ higher mortality rates especially pregnant women
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How is Hepatitis G special
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(no capsid) chronic disease similar to HCV
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How is Herpes Simplexvirus special
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reside in ganglia of innervating neurons to skin; infant - HSV2; whitlow = finger infxn; asymptomatic carriers
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How is Herpesvirus special
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tegument b/t capsid & envelope; capable of acute, latent, persistent infxn
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How is HIV-1 special
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replicates best in activated Tcells; IL2 not efficiently produced->crippled innate immunity; AIDS indicators= Kaposi's, Bcell Lymphomas
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How is HIV-2 special
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How is Human Herpesvirus 6 (&7) special
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HHV6 also called Roseola or exanthema subitum; rash from activation of Tcells
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How is Human Herpesvirus 8 (KSV - Kaposi's sarcoma herpes) special
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Kaposi's occurs in AIDS pts; Castleman's = lymphoid tumors thruout the body
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How is Human T-cell leukemia virus (trans-acting retrovirus) special
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carries tax-> activates cell genes & autostimulating Il2 loop
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How is Influenza A special
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antigenic drift & shift & reassortment -> new strains; resp diseases & encephalitis from aspirin
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How is Influenza B special
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cause of 1/4 hospitalizations as influA
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How is Influenza C special
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How is JC Virus special
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only get disease in immunocompromised
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How is La Crosse virus special
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7d incubation then sudden onset of symptoms, usually self-resolving
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How is Lentivirus ("slow viruses") special
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xtra genes for auxiliary, regulatory & accessory proteins
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How is Measles /morbillivirus/ rubeola special
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humans = host; maculopapular rash & Kopliks spots; replicate in RT but spreads thru blood -> disease; can spread cell-cell, avoids Abs
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How is Molluscum Contagiosum special
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2-12 month disease course
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How is Monkey B Virus special
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replicate in hindbrain, >80% mortality, neuro impairmt, possible bioterrorist agent
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How is Monkeypox special
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US outbreak 2003 from imported rodents & housepets
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How is Mumps virus special
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clinical: bilateral swelling of glands, CNS infxn in 50%, but mostly asymptomatic/ spread from URT epi via viremia
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How is Nairovirus special
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How is Norwalk-like Virus aka norovirus special
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self-limiting; 1-3d incub; capsid structure allows differentiation on EM
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How is Orthomyxovirus special
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enveloped, sphere or tube; complications = pneumonia & Reye's; M=matrix; H&N=envelop
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How is Papillomavirus special
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nonpermissive cells -> oncogenesis (16,18)
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How is Parainfluenza virus special
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croup = seal bark, using antisera typing to avoid expensive drug use; NO viremia
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How is Paramyxovirus special
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Hendra = Australian animals; Nipah = Malaysia & Singapore fruit bats
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How is Phlebovirus special
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How is Picornavirus special
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most assymptomatic, but shed virus; see entero, rhino, heparna, cardio, aptho
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How is Poliovirus (entero) special
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asymptomatic = most common; paralytic = lysis of LMN (or UMN) -> flaccid asymmetric paralysis
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How is Polyomavirus special
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BK: reactvtn of latent in kidney->severe UTI; JC/PML: reactvtn of latent-> viremia & CNS demyelintn; SV studied for vaccine
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How is Reovirus special
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very durable; see other family members: Rota, Orbi, Colti
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How is Respiratory syncytial virus special
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LRT infxn; zoonotic disease also
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How is Retrovirus special
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virion carries revtrans & 2tRNA; rex may be oncogenic
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How is Rhabdovirus (rabies = human found virus) special
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Catch in long incubation period for prophylactic vaccination w/ RIGG/HRIG
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How is Rhinovirus special
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acid labile; symptoms due to interferon; replicate below body temp; >50% URT, many serotypes
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How is Rift valley fever virus special
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50% mortality rate; endothelial cells disrupted -> bleeding
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How is Rotavirus special
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dsRNA never leaves capsid, uses ISVP to penetrate cell; IgA in gut -> immunity
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How is Rubella/Rubivirus special
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1/5 childhood rashes; can be more severe in adults -> arthralgia, CME, hypersensitivity
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How is SARS special
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travel to endemic area, temp > 100.5, Atypical resp infxn
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How is Smallpox aka Variola special
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very contagious, can go thru skin; humans= only host; possible bioterrorism; erradicated
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How is Uukuvirus special
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No human disease
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How is Vaccinia (cowpox or Milker's nodules) special
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original virus Jenner used for smallpox vaccine
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How is Varicella special
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incubtn = 14dd; more serious in adults who develop pneumonia;
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How is Varicella-Zoster Virus special
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fast growing, limited host range, latent in neurons; vaccine may be prophylactic
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How is West Nile encephalitis special
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no capsid
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How is West Nile Virus special
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mostly self-limiting, immunocompromised (age) risk factor, one serotype in NA
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How is Yellow fever special
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no capsid; vaccine given to military & travelers
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How is Zoster special
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severely painful rash at dermatome level, postherpetic neuralgia can develop
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What family of viruses does Adeno-associated virus belong to
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parvoviridae
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What family of viruses does Adenovirus belong to
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adenoviridae
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What family of viruses does Alphaherpesvirinae belong to
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herpesviridae
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What family of viruses does Alphavirus belong to
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togaviridae (arbo)
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What family of viruses does arbovirus belong to
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toga, bunya, flaviviridae
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What family of viruses does Arenavirus belong to
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arenaviridae
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What family of viruses does B19 (fifth disease) Erythema infectiosum belong to
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parvoviridae (smallest genome)
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What family of viruses does Betaherpesvirinae belong to
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herpesviridae
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What family of viruses does bird flu belong to
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orthomyxoviridae H5N1
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What family of viruses does BK virus belong to
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Papovaviridae
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What family of viruses does Bunyavirus belong to
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bunyaviridae (arbo)
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What family of viruses does Calicivirus belong to
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caliciviridae
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What family of viruses does California encephalitis virus belong to
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bunyaviridae (arbo)
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What family of viruses does Cardiovirus belong to
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picornaviridae
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What family of viruses does Coltivirus belong to
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reoviridae; noneveloped, dbl capsid
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What family of viruses does Coronavirus belong to
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coronaviridae
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What family of viruses does Coxsackievirus A belong to
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picornaviridae
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What family of viruses does Coxsackievirus B belong to
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picornaviridae
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What family of viruses does Crimean-Congo hemorrhagic fever virus belong to
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bunyaviridae (arbo)
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What family of viruses does Cytomegalovirus (CMV) belong to
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betaherpesvirinae
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What family of viruses does Dengue belong to
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Flaviviridae (arbo)
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What family of viruses does Echovirus belong to
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picornaviridae
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What family of viruses does Enterovirus belong to
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picornaviridae
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What family of viruses does Epstein-Barr Virus belong to
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Herpesviridae, gammaherpesvirinae
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What family of viruses does Filovirus belong to
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Filoviridae
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What family of viruses does Flavivirus belong to
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Flaviviridae (no capsid)
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What family of viruses does Foot and mouth disease virus belong to
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picornaviridae
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What family of viruses does Gammaherpesvirinae belong to
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herpesviridae
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What family of viruses does Hantaan virus belong to
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bunyaviridae (robo)
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What family of viruses does Hepatitis A (Heparnavirus) belong to
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picornaviridae
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What family of viruses does Hepatitis B (serum hepatitis) belong to
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Hepadnaviridae
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What family of viruses does Hepatitis C belong to
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Flaviviridae (no capsid)
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What family of viruses does Hepatitis D (delta agent) belong to
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not placed in a family
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What family of viruses does Hepatitis E aka enteric Non A, NonB hepatitis belong to
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Calicivirus (NWL)
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What family of viruses does Hepatitis G belong to
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Flaviviridae
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What family of viruses does Herpes Simplexvirus belong to
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alphaherpesvirinae
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What family of viruses does Herpesvirus belong to
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herpesviridae
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What family of viruses does HIV-1 belong to
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retroviridae (RNA->DNA)
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What family of viruses does HIV-2 belong to
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retroviridae (RNA->DNA)
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What family of viruses does Human Herpesvirus 6 (&7) belong to
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Herpesviridae, betaherpesvirinae
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What family of viruses does Human Herpesvirus 8 (KSV - Kaposi's sarcoma herpes) belong to
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Herpesviridae, gammaherpesvirinae
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What family of viruses does Human T-cell leukemia virus (trans-acting retrovirus) belong to
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retroviridae (RNA->DNA)
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What family of viruses does Influenza A belong to
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orthomyxoviridae
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What family of viruses does Influenza B belong to
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orthomyxoviridae
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What family of viruses does Influenza C belong to
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orthomyxoviridae
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What family of viruses does JC Virus belong to
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Papovaviridae
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What family of viruses does La Crosse virus belong to
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bunyaviridae (arbo)
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What family of viruses does Lentivirus ("slow viruses") belong to
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retroviridae (RNA->DNA)
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What family of viruses does Measles /morbillivirus/ rubeola belong to
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paramyxoviridae = pleomorphic
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What family of viruses does Molluscum Contagiosum belong to
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poxviridae (huge)
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What family of viruses does Monkey B Virus belong to
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Herpesviridae, alphaherpesvirinae
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What family of viruses does Monkeypox belong to
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poxviridae (huge)
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What family of viruses does Mumps virus belong to
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paramyxoviridae = pleomorphic
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What family of viruses does Nairovirus belong to
|
bunyaviridae (arbo)
|
|
|
What family of viruses does Norwalk-like Virus aka norovirus belong to
|
caliciviridae
|
|
|
What family of viruses does Orthomyxovirus belong to
|
orthomyxoviridae
|
|
|
What family of viruses does Papillomavirus belong to
|
papoviridae
|
|
|
What family of viruses does Parainfluenza virus belong to
|
paramyxoviridae = pleomorphic
|
|
|
What family of viruses does Paramyxovirus belong to
|
paramyxoviridae = pleomorphic
|
|
|
What family of viruses does Phlebovirus belong to
|
bunyaviridae (arbo)
|
|
|
What family of viruses does Picornavirus belong to
|
picornaviridae = tough & resistant
|
|
|
What family of viruses does Poliovirus (entero) belong to
|
picornaviridae
|
|
|
What family of viruses does Polyomavirus belong to
|
papoviridae
|
|
|
What family of viruses does Reovirus belong to
|
reoviridae; noneveloped, dbl capsid
|
|
|
What family of viruses does Respiratory syncytial virus belong to
|
paramyxoviridae = pleomorphic
|
|
|
What family of viruses does Retrovirus belong to
|
retroviridae (RNA->DNA)
|
|
|
What family of viruses does Rhabdovirus (rabies = human found virus) belong to
|
rhabdoviridae bullet shaped
|
|
|
What family of viruses does Rhinovirus belong to
|
picornaviridae
|
|
|
What family of viruses does Rift valley fever virus belong to
|
bunyaviridae (arbo)
|
|
|
What family of viruses does Rotavirus belong to
|
reoviridae; noneveloped, dbl capsid
|
|
|
What family of viruses does Rubella/Rubivirus belong to
|
togaviridae (non-arbo,noncytolytic)
|
|
|
What family of viruses does SARS belong to
|
coronaviridae
|
|
|
What family of viruses does Smallpox aka Variola belong to
|
poxviridae (huge)
|
|
|
What family of viruses does Uukuvirus belong to
|
bunyaviridae (arbo)
|
|
|
What family of viruses does Vaccinia (cowpox or Milker's nodules) belong to
|
poxviridae (huge)
|
|
|
What family of viruses does Varicella belong to
|
alphaherpesvirinae
|
|
|
What family of viruses does Varicella-Zoster Virus belong to
|
alphaherpesvirinae
|
|
|
What family of viruses does West Nile encephalitis belong to
|
Flaviviridae (arbo)
|
|
|
What family of viruses does West Nile Virus belong to
|
Flaviviridae (arbo)
|
|
|
What family of viruses does Yellow fever belong to
|
Flaviviridae (arbo)
|
|
|
What family of viruses does Zoster belong to
|
alphaherpesvirinae
|
|
|
What is the genome of Adeno-associated virus
|
naked ssDNA linear
|
|
|
What is the genome of Adenovirus
|
naked dsDNA linear
|
|
|
What is the genome of Alphaherpesvirinae
|
envelop linear dsDNA
|
|
|
What is the genome of Alphavirus
|
envelop/+ssRNA
|
|
|
What is the genome of arbovirus
|
see families
|
|
|
What is the genome of Arenavirus
|
envelop 2 circle ssRNA (- & +/-)
|
|
|
What is the genome of B19 (fifth disease) Erythema infectiosum
|
naked ssDNA linear
|
|
|
What is the genome of Betaherpesvirinae
|
envelop linear dsDNA
|
|
|
What is the genome of bird flu
|
segmented (-)ssRNA
|
|
|
What is the genome of BK virus
|
circular, dsDNA
|
|
|
What is the genome of Bunyavirus
|
envelop 3seg -ssRNA
|
|
|
What is the genome of Calicivirus
|
linear +ssRNA/naked
|
|
|
What is the genome of California encephalitis virus
|
envelop 3seg -ssRNA
|
|
|
What is the genome of Cardiovirus
|
#NAME?
|
|
|
What is the genome of Coltivirus
|
segmented dsRNA
|
|
|
What is the genome of Coronavirus
|
#NAME?
|
|
|
What is the genome of Coxsackievirus A
|
#NAME?
|
|
|
What is the genome of Coxsackievirus B
|
#NAME?
|
|
|
What is the genome of Crimean-Congo hemorrhagic fever virus
|
|
|
|
What is the genome of Cytomegalovirus (CMV)
|
envelop linear dsDNA
|
|
|
What is the genome of Dengue
|
envelop +ssRNA
|
|
|
What is the genome of Echovirus
|
#NAME?
|
|
|
What is the genome of Enterovirus
|
#NAME?
|
|
|
What is the genome of Epstein-Barr Virus
|
envelop linear dsDNA
|
|
|
What is the genome of Filovirus
|
envelop -ssRNA
|
|
|
What is the genome of Flavivirus
|
envelop +ssRNA
|
|
|
What is the genome of Foot and mouth disease virus
|
#NAME?
|
|
|
What is the genome of Gammaherpesvirinae
|
envelop linear dsDNA
|
|
|
What is the genome of Hantaan virus
|
envelop 3seg -ssRNA
|
|
|
What is the genome of Hepatitis A (Heparnavirus)
|
#NAME?
|
|
|
What is the genome of Hepatitis B (serum hepatitis)
|
envelop DNA, durable
|
|
|
What is the genome of Hepatitis C
|
envelop+ssRNA
|
|
|
What is the genome of Hepatitis D (delta agent)
|
envelop circular ssRNA
|
|
|
What is the genome of Hepatitis E aka enteric Non A, NonB hepatitis
|
linear +ssRNA/naked
|
|
|
What is the genome of Hepatitis G
|
envelop+ssRNA
|
|
|
What is the genome of Herpes Simplexvirus
|
envelop linear dsDNA
|
|
|
What is the genome of Herpesvirus
|
envelop linear dsDNA
|
|
|
What is the genome of HIV-1
|
envelop +ssRNAdiploid
|
|
|
What is the genome of HIV-2
|
envelop +ssRNAdiploid
|
|
|
What is the genome of Human Herpesvirus 6 (&7)
|
envelop linear dsDNA
|
|
|
What is the genome of Human Herpesvirus 8 (KSV - Kaposi's sarcoma herpes)
|
envelop linear dsDNA
|
|
|
What is the genome of Human T-cell leukemia virus (trans-acting retrovirus)
|
envelop +ssRNAdiploid
|
|
|
What is the genome of Influenza A
|
segmented (-)ssRNA
|
|
|
What is the genome of Influenza B
|
segmented (-)ssRNA
|
|
|
What is the genome of Influenza C
|
segmented (-)ssRNA
|
|
|
What is the genome of JC Virus
|
circular, dsDNA
|
|
|
What is the genome of La Crosse virus
|
envelop 3seg -ssRNA
|
|
|
What is the genome of Lentivirus ("slow viruses")
|
envelop +ssRNAdiploid
|
|
|
What is the genome of Measles /morbillivirus/ rubeola
|
#NAME?
|
|
|
What is the genome of Molluscum Contagiosum
|
linear dsDNA
|
|
|
What is the genome of Monkey B Virus
|
envelop linear dsDNA
|
|
|
What is the genome of Monkeypox
|
linear dsDNA
|
|
|
What is the genome of Mumps virus
|
#NAME?
|
|
|
What is the genome of Nairovirus
|
|
|
|
What is the genome of Norwalk-like Virus aka norovirus
|
linear +ssRNA/naked
|
|
|
What is the genome of Orthomyxovirus
|
segmented (-)ssRNA
|
|
|
What is the genome of Papillomavirus
|
naked circular dsDNA
|
|
|
What is the genome of Parainfluenza virus
|
#NAME?
|
|
|
What is the genome of Paramyxovirus
|
#NAME?
|
|
|
What is the genome of Phlebovirus
|
|
|
|
What is the genome of Picornavirus
|
#NAME?
|
|
|
What is the genome of Poliovirus (entero)
|
#NAME?
|
|
|
What is the genome of Polyomavirus
|
naked circular dsDNA
|
|
|
What is the genome of Reovirus
|
segmented dsRNA
|
|
|
What is the genome of Respiratory syncytial virus
|
#NAME?
|
|
|
What is the genome of Retrovirus
|
envelop+ssRNAdiploid
|
|
|
What is the genome of Rhabdovirus (rabies = human found virus)
|
enveloped - ssRNA
|
|
|
What is the genome of Rhinovirus
|
#NAME?
|
|
|
What is the genome of Rift valley fever virus
|
envelop 3seg -ssRNA
|
|
|
What is the genome of Rotavirus
|
segmented dsRNA
|
|
|
What is the genome of Rubella/Rubivirus
|
envelop/+ssRNA
|
|
|
What is the genome of SARS
|
#NAME?
|
|
|
What is the genome of Smallpox aka Variola
|
linear dsDNA
|
|
|
What is the genome of Vaccinia (cowpox or Milker's nodules)
|
linear dsDNA
|
|
|
What is the genome of Varicella
|
envelop linear dsDNA
|
|
|
What is the genome of Varicella-Zoster Virus
|
envelop linear dsDNA
|
|
|
What is the genome of West Nile encephalitis
|
envelop+ssRNA
|
|
|
What is the genome of West Nile Virus
|
envelop+ssRNA
|
|
|
What is the genome of Yellow fever
|
envelop +ssRNA
|
|
|
What is the genome of Zoster
|
envelop linear dsDNA
|
|
|
How is Adenovirus transmitted and diagnosed
|
fecal-oral, inhale, contact/ see next for labs
|
|
|
How is Alphaherpesvirinae transmitted and diagnosed
|
close contact
|
|
|
How is arbovirus transmitted and diagnosed
|
bite from infected arthopod
|
|
|
How is Arenavirus transmitted and diagnosed
|
inhale, food, fomites/ BSL3 containmt
|
|
|
How is B19 (fifth disease) Erythema infectiosum transmitted and diagnosed
|
oral,resp; sero = Igm&G PCR for DNA
|
|
|
How is bird flu transmitted and diagnosed
|
bird -> human
|
|
|
How is BK virus transmitted and diagnosed
|
ubiquitous
|
|
|
How is California encephalitis virus transmitted and diagnosed
|
virus neutrlzn assay (VN)& antiviral IgM
|
|
|
How is Coltivirus transmitted and diagnosed
|
Ag in RBC, sero of IgM -> acute vs pers
|
|
|
How is Coronavirus transmitted and diagnosed
|
serology for acute vs convalescent, isolation difficult
|
|
|
How is Coxsackievirus A transmitted and diagnosed
|
fecal-oral/ fecal culture; CSF has low neut #
|
|
|
How is Coxsackievirus B transmitted and diagnosed
|
fecal-oral/ fecal culture; CSF has low neut #
|
|
|
How is Cytomegalovirus (CMV) transmitted and diagnosed
|
close contact/PAP,lung biopsy-> owl eye inclusn; viral load by pp65; isoltn from urine; H&E
|
|
|
How is Echovirus transmitted and diagnosed
|
fecal-oral/ fecal culture; CSF has low neut #
|
|
|
How is Epstein-Barr Virus transmitted and diagnosed
|
saliva/mono: heterophile Ab;lymphocytosis
|
|
|
How is Filovirus transmitted and diagnosed
|
infect wide range of tissues/ LM, rtPCR, IgM,G
|
|
|
How is Flavivirus transmitted and diagnosed
|
usually bite/ feces; rev trans PCR; sero: Elisa & hemagglut
|
|
|
How is Hantaan virus transmitted and diagnosed
|
contact w/ rodents, urine/ viral Ag in blood, IgM
|
|
|
How is Hepatitis A (Heparnavirus) transmitted and diagnosed
|
fecal-oral/ sero antiHAV IgM
|
|
|
How is Hepatitis B (serum hepatitis) transmitted and diagnosed
|
parenteral, sexual/ serology: see provided chart on BB
|
|
|
How is Hepatitis C transmitted and diagnosed
|
infected blood, secretions etc/ Elisa; viral load from PCR
|
|
|
How is Hepatitis D (delta agent) transmitted and diagnosed
|
delta Ag; envelop has HBsAg
|
|
|
How is Hepatitis E aka enteric Non A, NonB hepatitis transmitted and diagnosed
|
fecal-oral, water/ variable IgG
|
|
|
How is Hepatitis G transmitted and diagnosed
|
differentiate from HCV w/ revtrans PCR; Elisa or RIA
|
|
|
How is Herpes Simplexvirus transmitted and diagnosed
|
close contact/ cell-cell
|
|
|
How is HIV-1 transmitted and diagnosed
|
Blood, sex, perinatal/ 3 Rapid tests; EIA, Elisa; Western blot =confirmation; also RIPA, PCR, latex agglutination
|
|
|
How is Influenza A transmitted and diagnosed
|
see ortho-epi&pandemics
|
|
|
How is JC Virus transmitted and diagnosed
|
ubiquitous
|
|
|
How is La Crosse virus transmitted and diagnosed
|
viral Ag in blood
|
|
|
How is Measles /morbillivirus/ rubeola transmitted and diagnosed
|
aerosols/ giant cells from fusion
|
|
|
How is Molluscum Contagiosum transmitted and diagnosed
|
EM
|
|
|
How is Monkey B Virus transmitted and diagnosed
|
monkey bite
|
|
|
How is Monkeypox transmitted and diagnosed
|
african squirrel-> rodents
|
|
|
How is Mumps virus transmitted and diagnosed
|
aerosols/ giant cells from fusion
|
|
|
How is Norwalk-like Virus aka norovirus transmitted and diagnosed
|
fecal oral/ Ab in feces (IEM); serology & rtPCR
|
|
|
How is Orthomyxovirus transmitted and diagnosed
|
4x titer, hemadsorption test, MAB
|
|
|
How is Papillomavirus transmitted and diagnosed
|
direct contact/ PAP smear, PCR,
|
|
|
How is Parainfluenza virus transmitted and diagnosed
|
aerosol or contact/ isolate, CPE, type
|
|
|
How is Paramyxovirus transmitted and diagnosed
|
aerosols/ giant cells from fusion
|
|
|
How is Poliovirus (entero) transmitted and diagnosed
|
fecal-oral/ ^ lymphs in CSF, no neuts, culture feces for virus
|
|
|
How is Polyomavirus transmitted and diagnosed
|
enter via RT/ postmortem foci of demye; urine; PCR, Elisa, IF,DNA
|
|
|
How is Reovirus transmitted and diagnosed
|
widespread, common, in sewage
|
|
|
How is Respiratory syncytial virus transmitted and diagnosed
|
aerosol/ IF & Elisa; sero; vrial Ag; isolate
|
|
|
How is Retrovirus transmitted and diagnosed
|
|
|
|
How is Rhabdovirus (rabies = human found virus) transmitted and diagnosed
|
bite via saliva; inhaled feces/ MAB & negri bodies
|
|
|
How is Rhinovirus transmitted and diagnosed
|
droplets, fomites, contact/ clinical diagnosis
|
|
|
How is Rift valley fever virus transmitted and diagnosed
|
viral Ag in blood
|
|
|
How is Rotavirus transmitted and diagnosed
|
fecal-oral/ virus in stool; latex agglut or Elisa; sero
|
|
|
How is Rubella/Rubivirus transmitted and diagnosed
|
resp droplets/ Sero: IgM = 1o infxn
|
|
|
How is SARS transmitted and diagnosed
|
large aerosol drops/ EIA, RTPCR
|
|
|
How is Smallpox aka Variola transmitted and diagnosed
|
fomite or lesion/ Guarnieri body
|
|
|
How is Varicella transmitted and diagnosed
|
aerosol,contact/ clinical diag of rash
|
|
|
How is Varicella-Zoster Virus transmitted and diagnosed
|
aerosol, contact/ see varicella & zoster
|
|
|
How is West Nile Virus transmitted and diagnosed
|
IgM Elisa for CSF& serum
|
|
|
How is Zoster transmitted and diagnosed
|
aerosol,contact/ Tzank smear, IF
|
|
|
How is Adeno-associated virus treated
|
must have helper virus to replicate
|
|
|
How is Adenovirus treated
|
no antiviral; vaccinate military for types 4,7; labs = PCR for typing, intranuclear inclusions
|
|
|
How is Arenavirus treated
|
supportive therapy; ribavirin -> Lassa; avoid rodents & their urine/feces
|
|
|
How is B19 (fifth disease) Erythema infectiosum treated
|
no antivirals, vaccines for animals only
|
|
|
How is bird flu treated
|
oseltamivir (Tamiflu)
|
|
|
How is Bunyavirus treated
|
no antiviral/ control vector and host
|
|
|
How is California encephalitis virus treated
|
see bunyavirus
|
|
|
How is Coltivirus treated
|
self-limiting; avoid tick bites; vaccines only for at risk work
|
|
|
How is Coronavirus treated
|
no vaccines or antivirals for humans;developing SARS vaccine
|
|
|
How is Coxsackievirus A treated
|
Good hygiene, clean water, No vaccine, pleconaril if early
|
|
|
How is Coxsackievirus B treated
|
Good hygiene, clean water, No vaccine, pleconaril if early
|
|
|
How is Cytomegalovirus (CMV) treated
|
Gancyclovir = acyclovir analog w/ possible toxicity, TK -> drug resistance; Foscarnet->inhibit DNA polymerase, for gancyclovir resistance
|
|
|
How is Echovirus treated
|
Good hygiene, clean water, No vaccine, pleconaril if early
|
|
|
How is Enterovirus treated
|
|
|
|
How is Epstein-Barr Virus treated
|
no antiviral, vaccine or prevention
|
|
|
How is Filovirus treated
|
no antiviral or vaccine/ QUARANTINE
|
|
|
How is Flavivirus treated
|
no antiviral, some vaccines; supportive care; vector control; see diseases
|
|
|
How is Hantaan virus treated
|
see bunyavirus; rodent control and wear mask cleaning; resp support
|
|
|
How is Hepatitis A (Heparnavirus) treated
|
no antiviral, vaccine required for OK schools; hygiene
|
|
|
How is Hepatitis B (serum hepatitis) treated
|
INFa for chronic infxn; Entecavir; Telbivudine, vaccine for high risk
|
|
|
How is Hepatitis C treated
|
No vaccine; IFNa w/ Ribavarin
|
|
|
How is Hepatitis D (delta agent) treated
|
no vaccine, no antiviral/ try to prevent HBV
|
|
|
How is Hepatitis G treated
|
transmitted in blood
|
|
|
How is Herpes Simplexvirus treated
|
most people exposed to at least HSV1/ acyclovir, but no vaccine
|
|
|
How is HIV-1 treated
|
Fuzeon=fusion inhibitor (gp120gp41) NRTI=resembles building blocks of NAs; NNRTI=disrupt revtrans fxn; Protease inhibitors; Integrase inhibitors; Chemokine receptor homologs & ligands
|
|
|
How is Human Herpesvirus 6 (&7) treated
|
self-limiting, CMI
|
|
|
How is Influenza A treated
|
see ortho; Zan=Relenza; Oseltamavir =Tamiflu (not prophylactic)
|
|
|
How is Influenza B treated
|
primarily Human virus
|
|
|
How is La Crosse virus treated
|
see bunyavirus
|
|
|
How is Measles /morbillivirus/ rubeola treated
|
MMWR (live)/ clinical diag + MAB; passive immun -> compromised; no antiviral
|
|
|
How is Molluscum Contagiosum treated
|
remove or burn off growths
|
|
|
How is Monkey B Virus treated
|
clean wound, prophylatic acyclovir, monitor serology
|
|
|
How is Mumps virus treated
|
live MMR; no antivrial/ isolate from saliva, urine, CSF; sero = 4xIgG, IgM
|
|
|
How is Norwalk-like Virus aka norovirus treated
|
no vaccines or antivirals; treat symptoms; good hygiene and food cleaning
|
|
|
How is Orthomyxovirus treated
|
vaccine changes every year; Amantidine, Zanamivir, Ribovarin,
|
|
|
How is Papillomavirus treated
|
vaccine being developed; LN2 warts, laryngeal surgery, IFN injxn?
|
|
|
How is Parainfluenza virus treated
|
no vaccine or antiviral/ croup needs monitoring; nebulizer used
|
|
|
How is Poliovirus (entero) treated
|
vaccine (IPV or OPV) in developed countries; Pleconaril
|
|
|
How is Polyomavirus treated
|
no antivirals, vaccine/ serious in immunosuppressed; most adults have it, but asymptomatic
|
|
|
How is Reovirus treated
|
no antiviral or vaccine in general
|
|
|
How is Respiratory syncytial virus treated
|
Ribavarin via nebulizer; passive immun for compromised
|
|
|
How is Rhabdovirus (rabies = human found virus) treated
|
vaccine for postexposure & prophylaxis; supportive car
|
|
|
How is Rhinovirus treated
|
good hygiene, supportive therapy for symptoms, no vaccine
|
|
|
How is Rotavirus treated
|
electrolyte replacement for hydration; rotashield in underdeveloped
|
|
|
How is Rubella/Rubivirus treated
|
MMR vaccine, no antiviral (reduces # seronegative mothers
|
|
|
How is SARS treated
|
Ribavarin, steroids etc; QUARANTINE
|
|
|
How is Smallpox aka Variola treated
|
vaccine; prophylactic VIG 1st; Cidofovir 2nd
|
|
|
How is Varicella treated
|
high doses of acyclovir; VZIG-> passive immunity
|
|
|
How is Varicella-Zoster Virus treated
|
high doses of acyclovir; VZIG-> passive immunity; new vaccine @ 2y/o
|
|
|
How is West Nile encephalitis treated
|
no human vaccines; may be developed
|
|
|
How is West Nile Virus treated
|
self-limiting unless compromised
|
|
|
How is Yellow fever treated
|
attenuated vaccine, may be protective against other flavis
|
|
|
How is Zoster treated
|
high doses of acyclovir; see VZV
|
