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18 Cards in this Set
- Front
- Back
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Name Reovirus family
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Rotavirus
Orthoreovirses Coltivirus DS + RNA |
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DO NOT CAUSE MAJOR DISEASE. cause mid upper resp. and GI infection. No test, no treament, or name. 75% seropostive
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ORTHoreoviruses,
Reovirus family |
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Problem ic chilldren under 2, get diarrhea, death from dehydration. Oral vaccine (LIVE). ISVP. INfects birds mammals and humans
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Rotavirus
Reovirus family |
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Colorado Tick fever, rodents are reservior. Must determine between Colorado/or Rocky Mountain
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Coltviruses
Reovirus family |
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enveloped + ss RNA icosahedral
Alphavirus and Rubivirus |
Togavirus family
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Which is spreaded by Mosquitoes? Alphavirus or Rubivirus
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Alphavirus
Togavirus family |
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group is unique because there is NO vector! GERMAN MEASLES – rubella. Disease is spread by respiratory droplets. Live attenuated vaccine is part of MMR
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Rubivirus
Togavirus family |
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Hep C. Arboviruses trans by mosquitoes, West Nile, Dengue, and Yellow fever. Reservoir BIRDS
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Flavivirdae
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A. Hantavirus – enveloped segmented, negative ssRNA
1. Spread by rodents only, NOT mosquito borne 2. Breathe aerosols with urine - LETHAL pulmonary disease from tissue destruction |
Bunyavirdae
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1. Mosquito transmitted Bunyaviridae
2. Disease of livestock, supportive therapy for humans to relieve fever, muscle aches, headache – rare to infect eye or brain |
Rift valley fever and California encephalitis –Bunyavirdae
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1. Enlarged liver (hepatomegaly)
2. Jaundice – yellow skin from too much bilirubin 3. Dark urine – bilirubin not broken down 4. Lymphadenopathy and muscle pain B. Some recover, some develop chronic disease or carcinoma |
Hepatitis
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a Picornavirus - genus Heparnavirus
1. 3-6 week incubation period, non cytolytic 2. Generally considered mild (44% in US seropositive Stable Virus, Killed vas U.S. nut live in China |
Hep A
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1. ONLY Hepatitis Virus that is a DNA virus
2. Hepadnavirus genus– enveloped, partially ds circular DNA genome, icosahedral 3. Must make RNA intermediate – virus brings RT 4. Can integrate into host genome and cause liver cancer! Hase Dane Particle |
HEP B
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Virus - Flavivirus – RNA genome - Hepacivirus genus – positive sense RNA, enveloped, icosahedral
Disease 1. Humans and chimps only 2. More than 170 million carriers – asymptomatic carriers can spread 3. Spread by blood, needles, sex or perinatally 4. More likely to cause chronic disease 5. 2 week – 6 month incubation 6. Increases liver cancer from high cell turnover C. Hepatitis C Diagnosis/Treatment 1. Diagnosed by ELISA 2. Treatment with IFN-alpha or ribavirin – 50% recovery D. Hepatitis G 1. Another Flavivirus – sim to HEP __ but less virulent 2. Chronic infection – unlikely a major human pathogen |
HEP C
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uses HBV and cell to produce protein – viral parasite – REQUIRES active HBV as a helper – ONLY in patients with active HBV – SUPERINFECTION to HBV
C. Hep ____ makes HBV worse |
HEP D
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resembles HEP A
related to norwalk virus 2-8 week incabution (mild disease) |
HEP E
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A. Proteinaceous infectious particles that cause various spongiform encephalopathies (slow neurodegenerative diseases)
a. PrP – protein protein – amyloid protein (insoluble fibrous protein) b. Binds to proteins on your cells and causes refolding? B. Prions are NOT antigenic, inflammatory or immunogenic C. Affect normal proteins and cause misfolding D. Sometimes called slow viruses – but they are NOT viruses E. EXTREMELY resistant to heat, disinfectants and radiation |
Prions
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1. Scrapie (sheep)
2. Chronic Wasting Disease (elk in Colorado) 3. BSE (humans and cattle, in humans called nvCJD) 4. Kuru (Cannibals of New Guinea), 5. CDJ (middle age 40-50yo) Creutzfeldt-Jakob disease B. Transmission 1. Injection 2. Transplantation 3. Contact with medical equipment (brain electrodes) 4. Food 5. Genetics for human familial (CJD) |
Prions
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