Virology 15: Antiviral Drugs

Front 1

amantidine, which is effective against ___, targets ___, which is a ___. this inhibits ___

Back 1

influenza A
M2
ion channel
uncoating

Front 2

anti-HSV drugs (3)

Back 2

ara-A
acyclovir
foscarnet

Front 3

ara-A is a ___. it is used against ___
it acts by ___ (2)

Back 3

adenine analog
HSV encephalitis
inhibiting viral DNA pol
inserting into viral DNA

Front 4

acyclovir is a ___

Back 4

guanosine analog

Front 5

acyclovir is effective against both ___ and ___. a higher dose is required for ___

Back 5

HSV
VZV
VZV

Front 6

anti-CMV drugs (2)

Back 6

ganciclovir
foscarnet

Front 7

ganciclovir is a ___

Back 7

guanosine analog

Front 8

NRTIs

Back 8

AZT
ddI
ddC

Front 9

___ are a group of endogenous antiviral molecules.

Back 9

IFNs

Front 10

T/F: IFNs are pre-synthesized and released in response to infection

Back 10

false: synthesized de novo

Front 11

T/F: IFN released against virus x also helps fight virus y

Back 11

true

Front 12

IFNa is synthsized by ___. there are ___ loci.

Back 12

leukocytes
15

Front 13

IFNb is synthesized by ___. there are ___ loci.

Back 13

fibroblasts
1

Front 14

IFNg is synthesized in ___. it has ___ loci

Back 14

lymphocytes
1

Front 15

___ has the highest antiviral activity

Back 15

IFNa

Front 16

___ is the strongest IFN inducer. it causes the ___ to dissociate from the IFN DNA

Back 16

dsDNA
repressor

Front 17

signalling from IFNRs is directed at ___, which produce ___

Back 17

interferon response sequence (IRS)
interferon regulated proteins (IRPs)

Front 18

T/F: IRPs block viral replication at multiple steps

Back 18

true

Front 19

IRP examples

Back 19

dsRNA dependent 2'-5' oligo A synthetase
PKR
ADAR
mx1

Front 20

2'-5' oligo A synthetase works on ___ viruses. it works by ___ which ___s.

Back 20

+ sense ssRNA
activating RNAse L
cleaves viral ssRNA

Front 21

PKR mechanism

Back 21

inactivating phosphorylation of eIF-2a
prevents synthesis of viral proteins

Front 22

___ synthesizes PKR inhibitors

Back 22

adenovirus

Front 23

MX proteins work on ___. the work by ___ing (3)

Back 23

RNA viruses.
associating with nucleocapsid
inhibiting nuclear transport
inhibiting transcription

Front 24

IFN has been used to fight ___ (3) with modest success

Back 24

HBV
HCV
CMV

Front 25

viruses inhibit IFN defense by (4)

Back 25

inhibiting IFN synthesis
making decoy receptors
inhibiting IFN signalling
interfering with IRPs

Front 26

viruses which inhibit IFN signalling (2)

Back 26

polyoma
adenovirus (E1A)