Virology 06 Human Papillomaviruses And Other Dna Tumor Viruses*

Front 1

In vivo, papilloma virus replication is linked to the differentiation of what

Back 1

The infected squamous epithelium

Front 2

What is notable about the HPV genome?

Back 2

It contains several open reading frames, all on the same strand

Front 3

How is HPV transmitted

Back 3

By direct skin contact or sexual contact

Front 4

HPV is linked to which cancer(s)?

Back 4

Human cervical carcinoma and ano-genital cancers

Front 5

HPV is highly restricted in its tissue tropism and replicates only in:

Back 5

Epithelial cells (skin and mucous membranes)

Front 6

How is HPV’s double-stranded covalently closed circular DNA maintained?

Back 6

In an episomal state in relatively low copies in undifferentiated dividing basal cells where early genes are expressed

Front 7

Which two early HPV genes were stressed in class?

Back 7

E6 and E7

Front 8

HPV proteins E6 and E7 do what?

Back 8

They target tumor suppressor gene products p53 (E6) and Rb (E7) and control entry into the G1/S phase of the cell cycle.
They also stimulate cell proliferation by activating cyclins A and E

Front 9

Why is HPV very difficult to grow in vitro?

Back 9

Terminally differentiated keratinocytes are difficult to maintain in culture

Front 10

In HPV, what only occurs in terminally differentiated keratinocytes?

Back 10

Late gene products and lytic DNA replication occur only in terminally differentiated keratinocytes

Front 11

What does a Papilloma result from?

Back 11

Dysregulated proliferation of basal cells

Front 12

HPV 6 and 11 infect mucosal epithelia and are associated with:

Back 12

Condylomata acuminata of the genital tract

Front 13

The most common HPV types (types 1, 2, 3 and 4) are associated with what

Back 13

They infect keratinized surfaces, especially on the hands (2, 4) and feet (1), causing common warts. Also Flat warts (3, 10).

Front 14

HPV 5 and 8 (and, less commonly, HPV 14) are associated with what

Back 14

Epidermodysplasia verruciformis, an autosomal recessive immunodeficiency with disseminated warts

Front 15

HPV 6 and 11 are associated with what

Back 15

They infect mucosal epithelia and are associated with condylomata acuminata of the genital tract

Front 16

Respiratory papillomatosis is associated with what

Back 16

Oral and/or laryngeal papilloma caused by HPV 6 and 11, obstructing the airway
Found in young children infected during delivery

Front 17

HPV 16 and 18 are associated with what

Back 17

They are associated with cervical intraepithelial neoplasias (CIN) or with invasive carcinoma, high grade dysplasias and carcinomas

Front 18

What test has decreased incidence of cervical cancer?

Back 18

Pap smear

Front 19

Name three members of the Polyoma virus family

Back 19

SV40
BKV
JCV

Front 20

What is BKV associated with

Back 20

Persists in kidney, associated with hemorrhagic cystitis, ureteral stenosis, and some urinary tract illnesses

Front 21

What is JCV associated with

Back 21

Progressive multifocal leukoencephalopathy (PML) in immune-compromised individuals and advanced disseminated malignancies

Front 22

Describe progressive multifocal leukoencephalopathy (PML)

Back 22

A subacute demyelinating disease in immunocompromised individuals and a common infection of early childhood that affects white matter.
Multiple neurological symptoms
Caused by JC virus

Front 23

What does progressive multifocal leukoencephalopathy result in

Back 23

Impairments to speech, vision, coordination, paralysis of the limbs, death

Front 24

Is the CSF normal in PML?

Back 24

Yes, the CSF is normal in PML

Front 25

If monkeys knew anything about micro, they would avoid SV40 T-antigen because:

Back 25

SV40 T-antigen inactivates monkey p53 and pRb

Front 26

Monkeys should avoid SV40 t-antigen since

Back 26

SV t-antigen binds and inhibits monkey PP2A

Front 27

Describe the most consistent genetic abnormality in Burkitt’s lymphoma

Back 27

Translocation of c-myc from chromosome 8 to the immunoglobulin heavy chain (IgH) locus on chromosome 14 in human Burkitt’s lymphomas.

Front 28

Where is Nasopharyngeal carcinoma prevalent?

Back 28

Southern China

Front 29

Which protein is relevant to Nasopharyngeal carcinoma?

Back 29

Latent Membrane Protein 1

Front 30

What does Latent Membrane Protein 1 in EBV do?

Back 30

It is an integral membrane protein that interacts with cellular signaling proteins TNF and receptor associated factors (TRAFs) to cause cellular activation