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30 Cards in this Set
- Front
- Back
In vivo, papilloma virus replication is linked to the differentiation of what
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The infected squamous epithelium
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What is notable about the HPV genome?
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It contains several open reading frames, all on the same strand
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How is HPV transmitted
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By direct skin contact or sexual contact
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HPV is linked to which cancer(s)?
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Human cervical carcinoma and ano-genital cancers
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HPV is highly restricted in its tissue tropism and replicates only in:
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Epithelial cells (skin and mucous membranes)
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How is HPV’s double-stranded covalently closed circular DNA maintained?
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In an episomal state in relatively low copies in undifferentiated dividing basal cells where early genes are expressed
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Which two early HPV genes were stressed in class?
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E6 and E7
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HPV proteins E6 and E7 do what?
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They target tumor suppressor gene products p53 (E6) and Rb (E7) and control entry into the G1/S phase of the cell cycle.
They also stimulate cell proliferation by activating cyclins A and E |
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Why is HPV very difficult to grow in vitro?
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Terminally differentiated keratinocytes are difficult to maintain in culture
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In HPV, what only occurs in terminally differentiated keratinocytes?
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Late gene products and lytic DNA replication occur only in terminally differentiated keratinocytes
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What does a Papilloma result from?
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Dysregulated proliferation of basal cells
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HPV 6 and 11 infect mucosal epithelia and are associated with:
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Condylomata acuminata of the genital tract
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The most common HPV types (types 1, 2, 3 and 4) are associated with what
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They infect keratinized surfaces, especially on the hands (2, 4) and feet (1), causing common warts. Also Flat warts (3, 10).
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HPV 5 and 8 (and, less commonly, HPV 14) are associated with what
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Epidermodysplasia verruciformis, an autosomal recessive immunodeficiency with disseminated warts
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HPV 6 and 11 are associated with what
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They infect mucosal epithelia and are associated with condylomata acuminata of the genital tract
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Respiratory papillomatosis is associated with what
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Oral and/or laryngeal papilloma caused by HPV 6 and 11, obstructing the airway
Found in young children infected during delivery |
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HPV 16 and 18 are associated with what
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They are associated with cervical intraepithelial neoplasias (CIN) or with invasive carcinoma, high grade dysplasias and carcinomas
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What test has decreased incidence of cervical cancer?
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Pap smear
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Name three members of the Polyoma virus family
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SV40
BKV JCV |
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What is BKV associated with
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Persists in kidney, associated with hemorrhagic cystitis, ureteral stenosis, and some urinary tract illnesses
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What is JCV associated with
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Progressive multifocal leukoencephalopathy (PML) in immune-compromised individuals and advanced disseminated malignancies
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Describe progressive multifocal leukoencephalopathy (PML)
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A subacute demyelinating disease in immunocompromised individuals and a common infection of early childhood that affects white matter.
Multiple neurological symptoms Caused by JC virus |
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What does progressive multifocal leukoencephalopathy result in
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Impairments to speech, vision, coordination, paralysis of the limbs, death
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Is the CSF normal in PML?
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Yes, the CSF is normal in PML
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If monkeys knew anything about micro, they would avoid SV40 T-antigen because:
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SV40 T-antigen inactivates monkey p53 and pRb
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Monkeys should avoid SV40 t-antigen since
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SV t-antigen binds and inhibits monkey PP2A
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Describe the most consistent genetic abnormality in Burkitt’s lymphoma
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Translocation of c-myc from chromosome 8 to the immunoglobulin heavy chain (IgH) locus on chromosome 14 in human Burkitt’s lymphomas.
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Where is Nasopharyngeal carcinoma prevalent?
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Southern China
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Which protein is relevant to Nasopharyngeal carcinoma?
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Latent Membrane Protein 1
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What does Latent Membrane Protein 1 in EBV do?
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It is an integral membrane protein that interacts with cellular signaling proteins TNF and receptor associated factors (TRAFs) to cause cellular activation
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