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51 Cards in this Set
- Front
- Back
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NRTI that needs deamination and phosphorylation to be active?
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Abacavir(ziagen)
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Drug used for NNRT resistance?
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Etravirine (intelence)
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Why is does resistance develop quickly to NNRTI?
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They bind to the hydrophoppbic pocket (allosteric site), easily mutated by virus
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Maraviroc
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Selzentry
CCR5 inhibitor Must have Trofile before initiation AE: cough, fever Black box: liver toxicity Cyp3a4 metabolism (di) |
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Ziagen
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Abacavir
NRTI AE: hypersensitivity rxn (hla b5701 test used to predict), may increase MI risk Liver metabolism, adjust in hepatic impairment |
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Videx
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Didanosine
NRTI AE: pancreatitis, peripheral neuropathy Dose adjustment based on Weight and renal function Take on empty stomach If administered with viread, take with food Has higher incidence of lactic acidosis and hepatic steatosis |
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Zerit
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Stavudine
NRTI AE: pancreatitis, peripheral neuropathy, lipostrophy Has higher incidence of lactic acidosis and hepatic steatosis and lipodystophy/lipoatrophy Dose adjustment based on weight and renal function |
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Viread
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Tenofovir
NRTI Also used for HBV AE: flatulence, diarrhea, renal impairment, decreased BMD Rquires renal dose adjustment Increases videx concentration when co-administered |
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Retrovir
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Zidovudine
NRTI AE: bone marrow suppression , hyperpigmentation of nails/skin Has higher incidence of lipodystrophy/lipoatrophy Liver metabolism Dose adjustment in severe renal impairment |
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Emtriva
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Emtricitabine
NRTI Active against HBV but not approved Rquires renal dose adjustment |
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Epivir
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Lamivudine
NRTI Also used for HBV Requires renal dose adjustment |
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Sustiva
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Efavirenz
NNRTI Take on empty stomach at bedtime AE: tertogenic, skin rash, cns effects, liver toxicity Strong cyp3a4 inhibitor Long half life DI with vfend |
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Viramune
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Nevirapine
NNRTI AE: skin rash, liver toxicity Cyp3a4 autoinducer |
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Intelence
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Etravirine
NNRTI Activity against 1st generation NNRTI resistance AE: skin rash, liver toxicity Cyp3a4 autoinducer |
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Isentress
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Raltegravir
Integrase inhibitor AE: hyperbilirubinemia(yellow skin/eyes), increased LFTs, increased SCr(muscle aches/pain/burning), Metabolized by glucoronidation (ugt 1a1)-DI with rifampin |
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Prezista
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Darunavir
PI Caution in pts with sulfonamide allergy Best activity against drUg resistant HIV |
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Reyataz
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Atazanavir
PI AE: nephrolithiasis, hyperbilirubinemia TAke with food DI: antacids, h2 blockers, PPI If taken with Viread, must also take Norvir |
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Norvir
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Ritonavir
PI PK booster-strong cyp3a4 inhibitor AE: perioral paresthesia, diarrhea DI: fluticasone and trazodone |
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Lexiva
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Fosamprenavir
PI Caution in pts with sulfonamide allergy |
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Viracept
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Nelfinavir
PI Dont take with ritonavir! |
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Aptivus
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Tipranavir
PI CAution in pts with sulfonamide allergy AE: intracranial hemorrhage |
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Absolute contraindications with protease inhibitors?
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Simvastatin, lovastatin, rifampin
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Treatment for uncomplicated Chlamydia?
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Azithromycin x1 dose
Doxycycline x7 days |
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Treatment of LGV-chlamydia?
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Doxycyline or erythromycin for 21 days
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Treatment for chlamydia in pregnant women?
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Erythromycin base or amoxicilln for 7 days
Azithromycin x1 dose |
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Treatment for uncomplicated Gonorrhea infection?
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Ceftriaxone/Cefexime x1 dose PLUS, if chlamydia isnt ruled out,
Azithromycin or doxycycline |
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Treatment of Gonococcal conjuctivitis gonnorrhea?
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Ceftriaxone x1 dose and saline solution
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Treatment of disseminated Gonorrhea infection?
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Ceftriaxone IV
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Treatment for Gonorrhea in pregnant women?
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Ceftriaxone
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Treatment of primary/secondary/early latent Syphilis? In PCN allergy?
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Benzathine PCN G x 1 dose
Doxycycline or tetracycline x14 days |
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Treatment of late latent or tertiary Syphilis? In PCN allergy?
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Benzathine PCN G x3 doses
DOxycycline/tetracycline x28 days |
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Treatment for neurosyphilis? In PCN allergy?
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Aqueous PCN G IV 10-14 days
Procaine PCN G IM + probenicid x10-14 days Pcn allergy: Desensitize patient |
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Treatment of syphilis in pregnant women? And if pcn allergic?
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Treat with appropriate stage and desensitize if allergic
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Jarisch-Herxheimer reaction?
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Occurs within first 24 hrs of syphilis treatment
Not an allergic reaction |
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Treatment of mild PID?
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Ceftrixone/cefoxitin/ceftizoxime PLUS
Doxycline +/- Flagyl |
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Treatment of PID?
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Cefotetan/cefoxitin IV + doxycyline PO/IV
Or Clindamycin IV + gentamicin IV |
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Treatment of Trichomoniasis?
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Flagyl x1 dose
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Genital wart treatment that should be avoided in pregnant women?
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Imiquimod, podophyllin, podofilox
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Treatment of sight threatening CMV Retinitis treatment?
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Ganciclovir implant + valganciclovir PO or Ganciclovir IV
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Treatment of peripheral lesions-CMV retinitis?
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Valganciclovir PO
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Treatment of oropharyngeal candidiasis?
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Fluconazole, clotrimazole troches, nystatin for 7-14 days
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Treatment of esophageal candidiasis?
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Fluconazole or itraconazole for 14-21 days
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Prophylaxis of PCP?
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Bactrim DS or SS
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Patient is G6PD deficient and needs PCP prophylaxis, what med should they take?
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Atovaquone or pentamidine
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Treatment of PCP?
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Bactrim for 21 days
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Prophylaxis of Taxoplasma encephalitis?
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Bactrim DS
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Treatment of taxoplasma encephalitis?
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Pyrimethamine + sulfadiazine + leucovorin for 6 weeks
Replace sulfadiazine with clindamyciin sulfa alllergy |
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Prophylaxis for myobacterium avium infection?
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Azithromycin is DOC
Rifabutin if cant tolerate |
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Treatment for myobacterium avium infection?
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Clarithromycin plus Ethambutol for 1 year
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What is the max dose clarithromycin when used for myobacterium avium infection treatment?
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One gram
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Treatment for crypotcoccus neoforms?
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Ampho B + flucytosine for 2 weeks, high dose fluconazole for 8 weeks, then fluconazole life long
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