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25 Cards in this Set
- Front
- Back
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when does infection of a pregnant mother cause the most severe form of neonatal herpes
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around 3rd trimester
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3 types of neonatal herpes
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SEM (skin, eyes, mouth)
CNS disseminated |
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causes chancroid
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H. ducreyi
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gold standard of HSV-2 dx
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viral culture
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high risk HPVs
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16,18
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benign HPVs
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6,11
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oncogenic proteins of high risk HPVs
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E6/7
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HPV gene that targets p53 for destruction
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E6
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HPV gene that targets Rb for destruction
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E7
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gene that controls expression of E6/7 in HPV that is lost in high risk HPV strains
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E2
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difference b/w high risk and low risk HPV
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high risk intergrate (16/18)
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type of p53 that is more susceptible to HPV induced degradation
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p53arg (arg at codon 72)
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viral STD with highest prevalence
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HSV
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viral STD with highest incidence
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HPV
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viral genome is tethered to chromosome of neurons
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HSV
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produces viral miRNA/siRNAs that block apoptosis upon infection
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HSV
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viral shedding lasts how long in HSV infection
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12 days
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infection can induce asymptomatic viral shedding up to 75% of days
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HSV
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when is neonatal herpes is spread to the infant
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birth
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when does an acquiring an infection carry in increased risk for spread to fetus
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3rd trimester
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do anti-viral drugs prevent transmission of HSV
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no
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subtypes of HPV that integrate into chromosomes
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16,18
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HPV gene that regulates E6/E7 expression that is disrupted in serotypes 16,18
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E2
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HPV types found in gardasil vaccine
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6, 11, 16, 18
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latency factors of HSV
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methylation
chromosomal tethering miRNAs (block apoptosis) |
