Viral Proteins, Etc... Micro

Front 1

-Host cell receptor: sialic acid
-Fusion protein
-M-matrix protein

Back 1

Paramyxovirus

Front 2

HN attachment

Back 2

PARAINFLUENZA

Front 3

G attachment

Back 3

RSV

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Winter/rainy Season epidemics

Back 4

RSV

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Spring/Fall epidemics

Back 5

parainfluenza

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Neg ssRNA, 8 segments

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Influennza

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-M protein = membrane matrix protein
-Lipid memb: derived from host cell
-Hemagluttinin and neuraminidase = what immunes sys recognizes

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Influenza

Front 8

Surface proteins VP1,2,3,4

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Entrvoirus

Front 9

VP1 = binding site for host receptors (hidden)

Back 9

Enteroviruses

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PrP

Back 10

Infectious proteins that lack nucleic acid or virus like structure

(prions)

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structural HIV genes

Back 11

POL, GAG, ENV

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GP120

Back 12

BINDS W/ CD4 CELLS
ENVELOPE PROTEIN

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GP 41

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ENVELOPE PROTEIN

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P24

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CAPSULE PROTEIN (HIV)

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P17

Back 15

MATRIX PROTEIN (HIV)

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TAT

Back 16

HIV
VIRAL TRANSACTIVATOR
(PROMOTES TXN)

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REV

Back 17

regulates splicing

Front 18

GAG-POL

Back 18

Ribosomal frameshift allows for two gene products from one RNA

gag = budding machine
pol = polymerase

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HIV PROTEASE

Back 19

Cleaves precursor Gag & gag-pol proteins to form new prtoein

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X4,R5, XR45

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HIV coreceptors; Effects memory cells

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VIF

Back 21

mediates degradation of Tetherin which acts to prevent release of viral particles

Front 22

how HIV is controlled

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CTL

Front 23

CCR5 deletion is risk factor for which virus

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West Nile Virus (helpful for HIV though)

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N protein (rapibes)

Back 24

txn, replication

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L protein (rabies)

Back 25

polymerase

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NS protein (rabies)

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Non-structural polymerase

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M protein

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Matrix protein (assembly & budding)

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cd56

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Receptor in neurons for Rabies

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Ds RNA 11 genomic segments

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Rotavirus

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VP 4

Back 30

cell attachment, hemaggluttination, neutralizing epitopes

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VP6

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Major group Ag

rotavirus

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VP7

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G antigen (neutralizing epitopes)

rotavirus

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NSP4

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Enterotoxin (rotavirus)

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Outer capsid (rotavirus)

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VP4/7

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Inner Capsid (rotavirus)

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VP6

Front 36

Cor protein (rotavirus)

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VP2

Front 37

3 Open Reading frames: What virus

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Noravirus

ORF1 = replication
ORF2 = Capsid protein VP1
ORF3 = unknown (VP2)

Front 38

Partially dsDNA circular virus
smallest Virus

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HBV

Front 39

CD46

Back 39

Receptor for measles

Front 40

E1-4 (HPV)

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Replication proteins

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E6-7 (HPV)

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oncogenetic proteins (HPV

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L1 HPV

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Capsid protein (vaccine antigen)

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L2 (HPV)

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capsid protein (minor)

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Latent Site HSV1

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Geniculate Ganglion

Front 45

Latent site HSV2

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DRG

Front 46

Latency site VZV

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DRG

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cd21

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EBV

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UL 54

Back 48

CMV; DNA polymerase

Front 49

UL 97 PROTEIN

Back 49

CMV Kinase, phosphorylates gancyclovir

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Inclusion Bodies

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DX for cmv

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E2 mediated attachment

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HCV

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NS3/4A PROTEASE

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HCV - prevents IFN -B induction

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Hep E dangerous trimester

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3rd

Front 54

CMV dangerous trimester

Back 54

1st

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GAG

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nucleocapsid protein

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NEF

Back 56

HIV

DOWNREGULATES MHC1 and CD4 expression (reduces chance of CD8 killing)

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VIF

Back 57

viral infectivity factor

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Herepes Envelope

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From the nucleus not the CELL MEMBRANE!

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Heparan sulfate

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Cellular receptor for herpes