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53 Cards in this Set

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Ctrl LCMV
eliminate colony (vertical and horiontal spread)

zoonotic disease (hamster)
gross path mousepox
visceral congestion
splenomegaly
white hepatic and splenic necrotic foci
peritoneal exudate
focat pancreatic necrosis
erosive enteritis
vesicular pox lesions on extremities
histopath of mousepox
IB epithelial cells, sm int, pancreas
Dx ctrol mousepox
Dx:
Elisa, ifa,pcr, hai

ctrl:
prevent exposure
vaccine
test mouse cell tumors before implanting
et of lymphocytic choriomeningitis virus
areanviridae
trans of LCMV
urine
saliva
persistent subclinical in utero and perinatal
clin signs LCMV
none
occasionally:
CNS
decreased growth
hunched posture
gross / histopath of LCMV
gross
none
focal visceral necrosis
splenomagaly

histo:
lymphocytic infiltration to meninges, choroid plexus, submeningeal and subchorioid perivascular spaces
viral diseases affecting mice
sendai virus
pneumonia virus of mice (PVM)
mouse hepatitis virus MHV
mouse parvovirus mpv
epizootic diarrhea of infant mice EDIM
mousepox
lyphocytic choriomeningitis virus LCMV
mouse viruses that also affect rats
sendai and pneumonia virus of mice
Et of sendai virus
both:
paramyxoviridae - parainfluenza
transmission of sendai virus
mouse - direct contact
rat - direct contact
aerosolization
sendai clinical signs
mouse:
none
labored breathing
reduced fecundity
immunosuppresive
death (nude DBA2)

rat: none
Gross path of sendai virus
mouse:
red to tan foci
airways may have exudate

rat:
lungs are mottled with red to tan
sendai histopath
mouse
alveolar and bronchiolar necrosis with neutrophilic infiltrate

bronchial swuamous metaplasia


rats:
mild focal interstitial peumonia with lymphoid perivasculitis

alveolar mac hyperplasia

bronchiolar exudate
dx of sendai virus
both - elisa, pcr
treatment of sendai virus
mouse - none; management burnout, rederive

rat - none
ctrl of sendai virus
both:
prevent exposure
sanitation
management
species that sendai virus affects
mouse
rat hampster
guinea pig
et of pneumonia virus of mice
both - paramyxoviridae - G. pnemovirus
transmission of pneumonia virus of mice
both -
direct contact
aerosols
fomites
clinical signs of pneumonia virus of mice
both -
none (death of nude mice)
gross and histo path of pneumonia virus of mice
both: gross - none

both histo = pulmonary lymphoid perivasculitis
Dx of pneumonia virus of mice
both - elisa, pcr, ifa
control of pneumonia virus of mice
sanitation
management
avoid housing mice / rats together
et of rat coronavirus
coronaviridae
aka rat coronavirus
sialodacryoadenitis (SDAV)
parker's rat virus
trans of rat corona virus
aerosol
direct
fomite
clin signs of rat corona virus
subclinical
chromodacryorrhea
enlarged submaxillary salivary gl
dacryoadenitis (exopthalmos, keratitis, corneal ulcers)
gross path rat coronavirus
enlarged salivary and lacrimal gl
edematous cervical ln
yellow gray foci in harderian gl
histopath of rat coronavirus
salivary gl:
acinar and ductal epithelial necrosis
interstitial edema
squamous metaplasia
Dx and ctrl rat coronavirsu
dx - pcr / elisa

ctrl-sanitation, mgt,
et of mouse hepatitis virus
coronaviridae
trans of mouse hepatitis virus
fecal oral
aerosol
direct contact
not latent
clin signs mouse hepatitis virus
none
suckling mice - watery diarrea, death
weanlings - obstipation
postweanling-hunched, wt loss,rough hair
nude: progressive wasting
gross path of mouse hepatitis virus
sucking - flaccid dstention of liquid contents

wenaling - cecal / rectal impaction of dry feces

older - multiple white hepatic foci

nude - nodular appearance
histopath of mouse hepatitis virus
GI - synctia formation in epithelium
liver - focal necrosis
nude - above, hepatic fibrosis and vascular synctia
Dx MHV
elisa
ifa
pcr
ctrol MHV
prevent exposure
sanitation
transmission of mouse parvo virus
fecal oral
urine
expired air
clin sighs MPV
none
gross / histo path of MPV
gross - none
histo - IB
Dx MPV
elisa
pcr
ifa
age/strain of mice
ctrl mpv
prevent entry
sanitation
et of EDIM
reoviridae - rotavirus
trans EDIM
fecal oral
direct contact
aerosol
clin signs EDIM
none
water / yellow diarrhea in 14-17d old mice

perineal fecal staining
stunted growth
gross path and histo of EDIM
gross:
scant, yellow gaseous intestinal contents

dried perianal fecal plug

hist:
villi tips - vacuolation and hydropic change
Dx and ctrol EDIM
Dx - elisa, pcr, ifa

ctrl" prevent exposure / sanitation
Et of mousepox
poxciridae - orthopoxvirus - s.ectromelia
trans mousepox
fecal oral (urine)
direct
aerosol
clin signs mousepox
hunched posture
conjunctivits
face sweellling
curaneous vesicular body rash
death
Dx LCMV
Elisa
PCR
whole blood titer / signs
neural tissue (footpad / cerebrum)