Viral Diseases Of Mice And Rats

Front 1

Ctrl LCMV

Back 1

eliminate colony (vertical and horiontal spread)

zoonotic disease (hamster)

Front 2

gross path mousepox

Back 2

visceral congestion
splenomegaly
white hepatic and splenic necrotic foci
peritoneal exudate
focat pancreatic necrosis
erosive enteritis
vesicular pox lesions on extremities

Front 3

histopath of mousepox

Back 3

IB epithelial cells, sm int, pancreas

Front 4

Dx ctrol mousepox

Back 4

Dx:
Elisa, ifa,pcr, hai

ctrl:
prevent exposure
vaccine
test mouse cell tumors before implanting

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et of lymphocytic choriomeningitis virus

Back 5

areanviridae

Front 6

trans of LCMV

Back 6

urine
saliva
persistent subclinical in utero and perinatal

Front 7

clin signs LCMV

Back 7

none
occasionally:
CNS
decreased growth
hunched posture

Front 8

gross / histopath of LCMV

Back 8

gross
none
focal visceral necrosis
splenomagaly

histo:
lymphocytic infiltration to meninges, choroid plexus, submeningeal and subchorioid perivascular spaces

Front 9

viral diseases affecting mice

Back 9

sendai virus
pneumonia virus of mice (PVM)
mouse hepatitis virus MHV
mouse parvovirus mpv
epizootic diarrhea of infant mice EDIM
mousepox
lyphocytic choriomeningitis virus LCMV

Front 10

mouse viruses that also affect rats

Back 10

sendai and pneumonia virus of mice

Front 11

Et of sendai virus

Back 11

both:
paramyxoviridae - parainfluenza

Front 12

transmission of sendai virus

Back 12

mouse - direct contact
rat - direct contact
aerosolization

Front 13

sendai clinical signs

Back 13

mouse:
none
labored breathing
reduced fecundity
immunosuppresive
death (nude DBA2)

rat: none

Front 14

Gross path of sendai virus

Back 14

mouse:
red to tan foci
airways may have exudate

rat:
lungs are mottled with red to tan

Front 15

sendai histopath

Back 15

mouse
alveolar and bronchiolar necrosis with neutrophilic infiltrate

bronchial swuamous metaplasia


rats:
mild focal interstitial peumonia with lymphoid perivasculitis

alveolar mac hyperplasia

bronchiolar exudate

Front 16

dx of sendai virus

Back 16

both - elisa, pcr

Front 17

treatment of sendai virus

Back 17

mouse - none; management burnout, rederive

rat - none

Front 18

ctrl of sendai virus

Back 18

both:
prevent exposure
sanitation
management

Front 19

species that sendai virus affects

Back 19

mouse
rat hampster
guinea pig

Front 20

et of pneumonia virus of mice

Back 20

both - paramyxoviridae - G. pnemovirus

Front 21

transmission of pneumonia virus of mice

Back 21

both -
direct contact
aerosols
fomites

Front 22

clinical signs of pneumonia virus of mice

Back 22

both -
none (death of nude mice)

Front 23

gross and histo path of pneumonia virus of mice

Back 23

both: gross - none

both histo = pulmonary lymphoid perivasculitis

Front 24

Dx of pneumonia virus of mice

Back 24

both - elisa, pcr, ifa

Front 25

control of pneumonia virus of mice

Back 25

sanitation
management
avoid housing mice / rats together

Front 26

et of rat coronavirus

Back 26

coronaviridae

Front 27

aka rat coronavirus

Back 27

sialodacryoadenitis (SDAV)
parker's rat virus

Front 28

trans of rat corona virus

Back 28

aerosol
direct
fomite

Front 29

clin signs of rat corona virus

Back 29

subclinical
chromodacryorrhea
enlarged submaxillary salivary gl
dacryoadenitis (exopthalmos, keratitis, corneal ulcers)

Front 30

gross path rat coronavirus

Back 30

enlarged salivary and lacrimal gl
edematous cervical ln
yellow gray foci in harderian gl

Front 31

histopath of rat coronavirus

Back 31

salivary gl:
acinar and ductal epithelial necrosis
interstitial edema
squamous metaplasia

Front 32

Dx and ctrl rat coronavirsu

Back 32

dx - pcr / elisa

ctrl-sanitation, mgt,

Front 33

et of mouse hepatitis virus

Back 33

coronaviridae

Front 34

trans of mouse hepatitis virus

Back 34

fecal oral
aerosol
direct contact
not latent

Front 35

clin signs mouse hepatitis virus

Back 35

none
suckling mice - watery diarrea, death
weanlings - obstipation
postweanling-hunched, wt loss,rough hair
nude: progressive wasting

Front 36

gross path of mouse hepatitis virus

Back 36

sucking - flaccid dstention of liquid contents

wenaling - cecal / rectal impaction of dry feces

older - multiple white hepatic foci

nude - nodular appearance

Front 37

histopath of mouse hepatitis virus

Back 37

GI - synctia formation in epithelium
liver - focal necrosis
nude - above, hepatic fibrosis and vascular synctia

Front 38

Dx MHV

Back 38

elisa
ifa
pcr

Front 39

ctrol MHV

Back 39

prevent exposure
sanitation

Front 40

transmission of mouse parvo virus

Back 40

fecal oral
urine
expired air

Front 41

clin sighs MPV

Back 41

none

Front 42

gross / histo path of MPV

Back 42

gross - none
histo - IB

Front 43

Dx MPV

Back 43

elisa
pcr
ifa
age/strain of mice

Front 44

ctrl mpv

Back 44

prevent entry
sanitation

Front 45

et of EDIM

Back 45

reoviridae - rotavirus

Front 46

trans EDIM

Back 46

fecal oral
direct contact
aerosol

Front 47

clin signs EDIM

Back 47

none
water / yellow diarrhea in 14-17d old mice

perineal fecal staining
stunted growth

Front 48

gross path and histo of EDIM

Back 48

gross:
scant, yellow gaseous intestinal contents

dried perianal fecal plug

hist:
villi tips - vacuolation and hydropic change

Front 49

Dx and ctrol EDIM

Back 49

Dx - elisa, pcr, ifa

ctrl" prevent exposure / sanitation

Front 50

Et of mousepox

Back 50

poxciridae - orthopoxvirus - s.ectromelia

Front 51

trans mousepox

Back 51

fecal oral (urine)
direct
aerosol

Front 52

clin signs mousepox

Back 52

hunched posture
conjunctivits
face sweellling
curaneous vesicular body rash
death

Front 53

Dx LCMV

Back 53

Elisa
PCR
whole blood titer / signs
neural tissue (footpad / cerebrum)