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25 Cards in this Set

  • Front
  • Back
The definition of Pathology is
The study of disease or the study of lesions associated
with disease in order to understand the mechanisms or processes involved in
disease.
Define etiology
cause of disease
The mechanism of a disease is called
pathogenesis
Structural changes induced by disease are called
Morphological description
Functional consequences that manifest themselves as "sickness"
Clinical
signs
What is a lesion, and what are two types of lesion
Lesion: is a visible abnormality in the tissue reflecting a pathologic process.

A lesion may be structural and/or functional
What is the difference between a sign and a symptom
Signs (a veterinary term, implying an observation of an abnormality) versus
symptoms (a medical term, implying an interpretation by the sufferer of an
abnormality
What 5 factors predispose a cell to injury
Severity
Metabolic activity
Ability to respond
type of cell
reaction (overreaction)
Cytochrome p450 enzymes are likely to be found in what type of reaction
Phase I reaction
Where in the cell would you find Cytochrome p450 family of enzymes
In the SER (smooth endoplasmic reticulum)
Cytochrome p450 enzymes are involved in metabolism of what compounds normally found in the body
steroids, sex hormones, and
vitamin D
Phase II enzymes perform what functions
attach soluble molecules
to toxic intermediates for excretion in bile or
urine
___________is used most often for
conjugation to reactive and toxic foreign
substances.
Glutathione
Tell which type of detoxification is primarily used by each organ (Phase I or Phase II)
1. Pancreatic Ductal cells
2. Adrenal Cortical cells
1. Phase II
2. Phase I
What 4 causes may lead to atrophy
lack of use
loss of innervation
loss of hormone
pressure
T/F - A cell that has undergone atrophy is not injured or dead
True
T/F - An increase in organ size due to increased cell number is called hypertrophy
False
Another term for __________ injury is degeneration
Reversible
T/F - A cell that has atrophied may be said to have undergone catabolism as well
True
Necrosis is always associated with the death of the organism - T/F
False
T/F - Postmortem autolysis is synonymous with necrosis
False -
Cell __________ and ____________ change are associated with reversible cell injury
Cell _swelling_ and __fatty__ change are associated with reversible cell injury
The nucleus of a cell that has swollen due to a reversible injury is still centrally located - T/F
True
Plasma memprane damage and subsequent leakage of ions leads to ______ and ________ going into the cell and _________ exiting the cell.
Plasma memprane damage and subsequent leakage of ions leads to _Ca++_ and _Na+____ going into the cell and __K+____ exiting the cell.
Which of these does not cause direct membrane damage
a) ionophores
b) necrosis
c) free radicals
d) toxins
b) necrosis