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17 Cards in this Set

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  • Back
_______________ swelling occurs in the first 15 minutes following ischemia
_Low amplitude_ swelling occurs in the first 15 minutes following ischemia
pH drops in a cell following ischemia due to _________ build up
pH drops in a cell following ischemia due to _lactic acid_ build up
The loss of of _____________
means the e- transport chain is
now broken and only partial
reduction of oxygen can now
occur leading to free radical
production
The loss of of _cytochrome c_
means the e- transport chain is
now broken and only partial
reduction of oxygen can now
occur leading to free radical
production
MPT stands for -
Mitochondrial Permeability Transition
Influx of ________ draws water into the cell, while ___________ entering the cell leads to activation of membrane lipases
Influx of __Na+___ draws water into the cell, while _Ca++___ entering the cell leads to activation of membrane lipases
Necrosis may be identified by light microscopy immediatel following the MPT - T/F
F necrosis may only be identified much later
The most damaging free radical is the
a Hydroxyl radical OH
b Superoxide anion O2
a Hydroxyl radical
The most common free radical is the
a Hydroxyl radical OH
b Superoxide anion O2
b superoxide anion
Selenium is neccesary for which enzyme to function
Glutathione peroxidase
Two important inducers of MPT are
Free radicals
Calcium
DUring apoptosis cytochrome c release from the electron chain is caused by what small protein
APAF-1 (Apoptosis Activating Factor - 1)
APAF-1/cytochrome c activate which caspase
A) Caspase 8
B) Caspase 9
C) Caspase 10
B)Caspase 9
Cytotoxic T cells activate which caspase
A) Caspase 8
B) Caspase 9
C) Caspase 10
C) Caspase 10
Receptor mediated apoptosis activates which caspase
A) Caspase 8
B) Caspase 9
C) Caspase 10
A) Caspase 8
Which caspase is responsible for most morphological changes in apoptosis
Caspase 3
______________ degradation allows the cell to "round up"
__Cytoskeletal_____ degradation allows the cell to "round up"
The two basic mechanisms by which
apoptotic necrosis can be triggered are
Induction
Release phenomenon