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67 Cards in this Set
- Front
- Back
4 Tissue Types
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Epithelium
Connective Tissue Muscle Nervous tissue |
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Connective Tissue Composition
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Cells
Fibers Ground substance |
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Characteristics of Epithelial Tissue
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- Fried Egg Appearance
- Lines surfaces of organs and tissues - Little intercellular space - Rest on a basement membrane (avascular) |
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Function of Epithelial Cell
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- Protection - skin
- Absorption - lungs, kidney - Excretion - one-way transport system - Secretion - serous/mucous and seromucous - Surface reception - special senses - Reproductive - gamete production |
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Name 2 special types of epithelial cells
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Endothelium
Mesothelium |
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Euchromatic
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having chromosomal material that is genetically active and stains lightly with basic dyes
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Function of Simple Cuboidal Cells
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Secretion
Absorption |
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Characteristics of Simple Cuboidal Tissue
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- Cells tall as they are wide
- Lining kidney tubules, parts of respiratory tract and ducts. |
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Fibroblast/Fibrocyte
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-Most common CT cell
-Prominent nucleus; -Round or oval in shape -Euchromatic Capable of motility |
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Function of Fibroblast/Fibrocyte
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synthesis (secretion) of connective tissue fibers and ground substance
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Characteristics of Simple Columnar Epithelial Tissue
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- Cells taller than they are wide
- Nuclei are typicall basal and in a row. - Location: Lining stomach, intestines, parts of respiratory tract, lining of ducts. -Frequently has microvilli |
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Function of Simple Columnar Epithelial Tissue
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Absorption
Secretion |
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Characteristics of Stratified squamous epithelium
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- multiple layers
- Specialized to resist forces of friction - Named by the most superficial layer - Keratinized - Non-keratinized |
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Characteristics of Psuedostratified columnar epithelium
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- crowded appearance
- Nuclei are in various positions (not in row) - Simple (all cells contact the BM) - Ciliated and Non-ciliated Found in: Respiratory tract Urogenital tract |
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Characteristics of Transitional epithelium
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- Scalloped/cobblestone appearance
- Variation of pseudostratified epithelium (simple) - Unique property that accommodates stretching - All cells contact basement membrane Found in: Urogenital tract |
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3 Types of Intracellular Junctions
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Anchoring junctions
Occluding junctions Communicating junctions |
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Basement Membrane
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-Separation between the epithelium and connective tissue
Function: Cell adhesion Diffusion barrier Cell growth |
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Apical Surface Modifications
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Microvilli
Cilia Stereocilia |
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Microvilli
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- Tiny surface projections at the Apical pole
Composition: Glycocalyx (coating of glycoproteins and other complex sugars) Function: Increases surface area Absorption |
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Axoneme
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– a cylindrical array of microtubules
- 9 “doublets” and two singles centrally located |
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Dynein arms
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force-generating protein present in cilia
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CT Fiber Types
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-Collagen
-Elastic |
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Types of Collagen
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I, II, III, IV
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4 Types of Connective Tissue
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Connective tissue proper
Cartilage Bone Blood |
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Collagen Type I
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- "Coarse Collagen
- 90% body's collagen - Skin, bone, tendons, ligaments, & interstitial spaces - H& E= orange to orange-pink - Trichrome= blue - Fibril forming collagen |
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Collagen Type II
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-Fine Collagen
-Cartilage/spinal cord |
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Collagen Type III
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- Synonymous with reticular fibers
- Silver or immunostaining Origin: Lymphoid organs, bone marrow, visceral organs, skin - Synthesized by reticular cells, fibroblasts & smooth muscle cells |
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Collagen Type IV
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Location: basement membranes
- Network forming collagen - Synthesized by epithelium |
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Fiber (Fibrous) Collagen
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- Elasticity & recoil
- stains pale pink - highly refractile -Origin: nuchal ligament, arteries, lung -synthesized by fibroblast, smooth muscle cells, chondroblasts |
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Ground substance
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- Glue between cells and fibers of CT
- Mixture of proteoglycans, glycosaminoglycans, and glycoproteins - effects morphogenesis, injury, and repair Stain: Washed out in routine preparations |
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Connective Tissue Proper
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Loose irregular
Dense irregular Dense regular Adipose tissue |
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Function of Mast Cell
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-inflammation
-antigenic stimulation |
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Reticular cells
Location Shape Cytoplasm -Function |
-Location: Lymphoid organs
-Shape: Stellate -Cytoplasm: Basophilic - "fixed” fibroblasts - Function: synthesize reticular fibers (type III collagen) |
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Macrophages
Origin Cytoplasm Function |
- 2nd most common CT cell
- Origin: blood monocyte - Cytoplasm; filled with lysosomes & debris -Function: phagocytic activity & inflammation |
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Loose irregular
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- highly cellular, few fibers
- fibroblast the predominant cell - soft and pliable - support and vascular supply for epithelia - interstitial tissue in most organs |
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Plasma Cell
Origin Cytoplasm Nucleus (characteristic) Function |
- Origin: Derived from B lymphocytes
-Cytoplasm: very basophilic cytoplasm; small cell in general - Nucleus- Heterochromatic “wagon wheel” - Function: Humoral antibody production |
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Types of cells present in Connective Tissue Proper
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Mesenchymal
Fibroblasts Reticular Fat Pericytes Mast Macrophages Plasma cells Leukocytes |
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Types of fat cells
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-Unilocular
-Multilocular |
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Mesenchymal cells
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Embryonic mesoderm
Undifferentiated Pluripotent Euchromatic nucleus |
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What cell synthesizes type III collagen (reticular fibers)
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Reticular cells
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Staining characteristic of adipose tissue.
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Does not stain in routine H&E
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Function of Adipose tissue
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- energy
- heat production |
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Mast cells
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-type of CT
-very large cell -Round nucleus -Cytoplasm -filled with large round, pleomorphic granules (heparin & histamine) |
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Sarco-
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Flesh
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SARCOLEMMA
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plasmalemma (plasma membrane) of a muscle cell
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SARCOPLASM
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cytoplasm of muscle
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SARCOPLASMIC RETICULUM
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a form of smooth endoplasmic reticulum, adapted to ion flux/conductance within a muscle cell
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myoblast
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myofiber precursor; cells that differentiate into mature muscle cell
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myofilaments
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The filaments of myofibrils constructed from actin and myosin proteins
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myofibril
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group of muscle myofilaments
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myofiber
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a single muscle cell, made up of multiple myofibrils, which are in turn made up of myofilaments
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Skeletal Muscle
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- voluntary
histlogical features - striated (because it possesses visible “striations” or lines) - multiple peripherally located nuclei -nucleiappear spase bc fibers are very large - myofibers arranged in groups called fascicles, surrounded by connective tissue |
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Fiber
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(myofiber) one cell
- product of multiple fusions of myoblasts during embryonic development - slightly tapered and blunt at either end; elongated, tubular morphology |
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Skeletal muscle nuclei (shape)
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oval (cigar-shaped) in longitudinal section, round in cross section, with clumped chromatin pattern
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Sarcomere
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the structural and contractile unit of muscle
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"Z” line
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centrally located black line in I band
acts to anchor actin filaments |
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“A” band
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- composed of centrally overlapping actin and myosin filaments at the either end of the band, and myosin alone in the center
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“I” band
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composed of the Z line and the actin filament ends at either pole of two adjacent sarcomeres
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“H” band
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- composed of myosin only in the center of the sarcomere
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“M” line
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- center of sarcomere, composed of “tails” of thick myosin filaments
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Sarcoplasmic reticulum
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Extensive network of tubules (webbing) surrounding/embracing the myofibrils
function as storage units for cations important in contraction |
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Triad
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- at A-I junction
- point at which terminal cisternae are aligned in “twos”, separated by a specialized invagination of the sarcolemma called a T-tubule - important in the conductance of Ca++ from sarcoplasmic stores across the sarcolemma to the myofibrils |
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endomysium
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CT fibers and matrix surrounding each individual myofiber (muscle cell)
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perimysium
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– CT fibers and matrix surrounding each individual myofiber (muscle cell)
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epimysium
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surrounds bundles (groups) of myofibers, call fascicles
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myotendinous junction
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the CT that surrounds the muscle and its components
is continuous with the CT which anchors the muscle to the bone |
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tendons
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- attach muscle to bone
- dense regular connective tissues - where tendons attach to bone = regions of transition, fibrocartilage is typically found |