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19 Cards in this Set

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A neonate presents with extensive blisters developing from a rash and a positive Nikolsky sign at the stratum granulosum.
Staphylococcal Scalded Skin Syndrome / Ritter's Disease
Similar to Staphylococcal Scalded Skin Syndrome, however affects older patients due to drug use and cleavage is between the epidermis and dermis.
Toxic Epidermal Necrolysis
A 6 year old, non vaccinated male presents with macules, papulovesicles, and crusted erosions on the trunk.
Key words: centripetal pattern; Dewdrops on rose petals; all stages of lesions.
Chickenpox/Varicella
What is the etiology of Chickenpox?
Human Herpesvirus 3
What are the complications of Chickenpox?
1) Reye's syndrome (fatty liver with encephalopathy)
2) Zoster (singles) - peripheral neuritis
3) More severe with age
How do you diagnose Chickenpox? Therapy? Contraindicated?
Prevention?
Positive Tzanck test for the presence of giant cells with nuclear inclusions.
Therapy: Acyclovir if severe.
Contraindicated: Salicylates
Prevention: Varivax, live attenuated virus
A child presents with fever, arthralgias, and sore throat with vesicular/ulcerating lesions in and around the mouth, palms/soles.
Hand-Foot-and-Mouth
Etiology of Hand-Foot-and-Mouth?
Coxsackie
A child presents with fever, headache, anorexia, and painful neck and extremities. Vesicular lesions on the tonsils or soft palate appear and ulcerate over the next 2 days.
Herpangina
An adult presents with malaise and recurrent tender vesicular (Tzanck test positive) lesions around the mouth or on the genitalia.
Herpes Skin Infections
Types of Herpes Skin Infections
Cold Sores - mouth
Gingivostomatitis - gingiva, teeth
Balantis - penis
Vulvovaginitis - vagina
Keratoconjunctivitis - eye
Gladiatorum - from wrestling mats
Etiology of Herpes Skin Infections?
Manifestations?
Epidemiology?
Herpes Simplex type 1 or 2
Grouped vesicles on an erythamatous plaque
Transmitted by saliva, contact with sores or kissing...RECURRENCES precipitated by STRESS
Therapy of Herpes Skin Infections?
Acyclovir
A 70 year old female cancer patient experiences severe, left-sided superficial trunk pain preceding vesicular eruption of an anterior chest dermatome.
Herpes Zoster
Etiology of Herpes Zoster?
Epidemiology?
Pathology?
Etiology: HHV 3 (VZV)
Epidemiology: Incidence increases with age (50-80) and immunosuppressed
Pathology: Inflammation of sensory root ganglia and skin of dermatome, which is hyperesthetic and severely painful. Vesicular eruptions occur on trunk where chickenpox was most severe and are unilateral.
THerapy of Herpes Zoster?
Acyclovir
Following a fever, a child presents with widespread vesicular lesions of one type. The rash is centrifugal and macular. Lesions are most numerous on the extremities and progress rapidly to severe ulcerations with scabs.
Smallpox (Variola)
Similar to Smallpox, but mild and involves lymphadenopathy?
Monkeypox
Epidemiology of Smallpox?
Diagnosis?
Therapy?
Epidemiology: Select agent (A)
Diagnosis: Guarnieri Bodies
Therapy: Cidovir