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26 Cards in this Set
- Front
- Back
Inheritance pattern of:
recurrent epistaxis skin discolorations mucosal small vessel AVMs GI bleeds |
Autosomal dominant
(hereditary hemorrhagic telangiectasias = Osler-Weber-Rendu syndrome) |
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Sequelae of tortuous superficial veins from chronically increased venous pressure
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poor wound healing
varicose ulcers |
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What diseases are associated with arteriolar vasospasm in small vessels of fingers and toes in response to cold temperatures or stress?
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Raynaud's disease
SLE CREST syndrome |
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hemoptysis, cough, dyspnea
hematuria, perforation of nasal septum, chronic sinusitis, otitis media, mastoiditis, pyoderma gangrenosum |
Wegener's granulomatosis:
- c-ANCA - nodular densities on X-ray - cyclophosphamide, steroids |
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- necrotizing granulomas in lung/ upper airway, necrotizing glomerulonephritis
- affects small vessels |
Wegener's granulomatosis
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- focal necrotizing vasculitis WITHOUT granulomas
- affects small vessels - p-ANCA |
microscopic Polyangiitis
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- vasculitis limited to kidney
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primary pauci-immune crescentic glomerulonephritis (few antibodies)
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Asthma, sinusitis, skin lesions, wrist/foot drop, p-ANCA
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Churg-Strauss syndrome
("allergic granulomatosis" or "angiitis") |
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granulomatous vasculitis with eosinophilia
ANCA-positive |
Churg-Strauss syndrome
("allergic granulomatosis" or "angiitis") |
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seizures, sensory changes, mental retardation, early-onset glaucoma
leptomeningeal angiomatosis |
Sturge-Weber syndrome
- small vessels |
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nevus flammeus
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port wine stain (Sturge-Weber)
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palpable purpura on buttocks, legs
arthralgias intestinal hemorrhage abdominal pain melena |
Henoch-Schonlein purpura
-small vessels: skin, GI, joints - follows URI - IgA immune complexes |
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Palpable purpura/petechiae
inflamed small vessels after PCN, phenytoin, sulfa, etc |
hypersensitivity vasculitis
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Smoker with intermittent claudication
superficial nodal phlebitis cold sensitivity severe pain in affected part autoamputation/gangrene |
Buerger's disease = thromboangiitis obliterans
- small and medium vessels - thrombosing vasculitis --> peripheral ischemia |
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Asian with fever, conjunctivitis, "strawberry tongue," lymphadenitis, desquamative skin rash
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Kawasaki disease
- small and medium vessels - may develop coronary aneurysm |
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Treatment for Wegener's granulomatosis
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cyclophosphamide
corticosteroids |
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treatment for Kawasaki disease
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IV Ig
Aspirin |
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treatment for Buerger's disease
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smoking cessation
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acute necrotizing vasculitis in infants/children
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Kawasaki disease
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Immune-complex mediated transmural vasculitis with fibrinoid necrosis
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polyarteritis nodosa
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fever, weight loss, malaise, abdominal pain, melena, headache, myalgia, HTN, neurologic dysfunction, cutaneous eruptions, aneurysms and constrictions
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polyarteritis nodosa
- small and medium vessels - Hep B in 30% - renal and visceral vessels, NOT lungs - lesions of different ages |
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Treatment for polyarteritis nodosa
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cyclophosphamide
corticosteroids |
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Young Asian female with fever, arthritis, night sweats, myalgias, skin nodules, eye problems, weak pulses in upper extremities, abdominal pain/diarrhea, increased ESR
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Takayasu's arteritis
- medium and large arteries |
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granulomatous thickening of aortic arch and/or proximal great vessels and/or mesenteric arteries
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Takayasu's arteritis
- medium and large arteries |
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Elderly female with unilateral headache, jaw claudication, impaired vision, increased ESR,
+/- polymyalgia rheumatica +/- systemic involvement |
temporal arteritis (giant cell arteritis)
- medium and large arteries - can lead to occlusion of ophthalmic artery |
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treatment of temporal arteritis
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high-dose steroids
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