Uworld Step 2 Ck Cards 51-150

Front 1

trastuzumab (Herceptin)

Back 1

a HER2 monoclonal Ab used to treat HER2 + breast CA
cardiotoxic, EKG prior to starting

Front 2

medication that alleviates pulmonary HTN the fastest

Back 2

nitroglycerin acutely

Front 3

drugs that can induce pancreatitis

Back 3

diuretics: thiazides, loops
IBS: 5-ASA, sulfasalazine
seizure: valproic acid
AIDS: didanosine, pentamidine

antibiotics: metro, tetracycline

Front 4

cat scratch disease treatment

Back 4

treat with oral azithromycin

Front 5

NASH - RFs and path

Back 5

risks are obesity, DM, HLD, TPN
impaired insulin response leading to fatty liver
pathology is macrovescicular steatosis with PMN infiltrates and necrosis

Front 6

Xray features of OA

Back 6

joint space narrowing, subchondral sclerosis, and osteophytes in the MCP and DIP

Front 7

contraction alkalosis treatment

Back 7

correct with IV NS and K supplimentation

Front 8

HIV pt with painful swallowing

Back 8

treat empirically with oral fluconazole (MCC is candidial infx)
failure to respond warrants esophagoscopy for HSV or CMV

Front 9

s/s of viral arthritis

Back 9

symmetric arthritis
distinguish from RA:
acute, lacks inflammatory markers ans resolves in 2 months

Front 10

pt with meningococcal meningitis treatment

Back 10

can be held against their will to prevent spread in the community

Front 11

mgmt of diabetic gastroparesis

Back 11

glycemic control
small and freq meals
promotility drugs

Front 12

treatment of v-tach

Back 12

if stable, use IV amiodarone or lidocaine
if unstable use cardioversion

Front 13

pain control in cancer pts

Back 13

if severe, can use short acting morphine then titrate narcotics to control pain

Front 14

dx of DKA

Back 14

blood glucose > 250
pH < 7.3
serum bicarb < 15

Front 15

DEXA recommendations

Back 15

women > 65 or >60 with risk factors (poor Ca, smoking, steroid, alcohol, low BMI, post-menopause)



DEXA < -2.5 is osteoporosis

Front 16

HCM

Back 16

hypertrophic cardiomyopathy murmur is harsh systolic at left lower sternal border and decreases with valsalva

Front 17

MCC of hypercoag disorder

Back 17

Factor V Leiden

Front 18

treatment of cocaine induced cardiac ischemia

Back 18

benzos, nitrates, and aspirin

Front 19

difference in AIDS retinitis HSV vs. CMV

Back 19

HSV: painful keratitis with peripheral pale lesions and central retinal necrosis

CMV: painless retinal vessel hemorrhages or fluffy granular lesions, usually without keratitis or conjunctivitis

Front 20

recurrent pneumonia in same anatomic location

Back 20

red flag for cancer, do a chest CT

Front 21

screening exam for newly dx cirrhosis

Back 21

endoscopy to detect esoph varices

Front 22

HIV prophylaxis

Back 22

if CD4 < 200, give TMP-SMX or pentamidine for PCP

if CD < 50, give azithro or clarithromycin for MAC prevention

Front 23

beta blocker antidote

Back 23

atropine and IV fluids 1st
if no improvement in BP give glucagon

Front 24

classic radio findings in osteosarcoma

Back 24

Codman's triangle
sunburst appearance

Front 25

disseminated histoplasmosis s/s , dx, tx

Back 25

fever, weight loss, N/V, cough, SOB, lymphadenopathy
seen in HIV with CD < 100
dx with antigen in the urine or serum
treat with itraconazole (fluconazole if can't tolerate)

Front 26

features, cause, tx of drug-induced interstitial nephritis

Back 26

fever, rash, arthralgias, hematuria, sterile pyuria, and eosinophiluria
causes: cephalosporins/PCNs, sulfonamides, NSAIDS, rifampin, phenytoin, allopurinol
treatment is to stop the offending drug

Front 27

Wegner's granulomatosis

Back 27

airway and glomerular involvement,
systemic vasculitis with tender nodules, palpable pupura, or ulcerations
c-ANCA +

treat with cyclophosphamide

Front 28

contraindications for bupropion

Back 28

seizure or eating disorder
things that predispose to seizures like EtOH or benzo

Front 29

years for screening for HBV and HCV s/p transfusions

Back 29

screen for HBV is transfused prior to 1986
screen for HCV if transfused prior to 1992
B before C...

Front 30

invasive aspergillosis

Back 30

usually in immunocomp pts wtih fever, cough, dyspnea, or hemptysis

the cavitary lesion with a halo on a chest CT

Front 31

treatment of ascites

Back 31

1. Na and water restriction
2. spironolactone
3. loop diuretic
4. paracentesis of 2 to 4 L/day as long as renal function is perserved

Front 32

known risk factors for pancreatic CA

Back 32

family Hx, chronic pancreatitis, smoking, DM, obesity, and a high fat diet

NOT alcohol

Front 33

HIV pt with bloody diarrhea, suspect what?

Back 33

CMV colitis

Front 34

TCA overdose

Back 34

CNS depression, hypotension, dilated pupils, hyperthermia, intestinal ileua, QRS elongation

treat by ABCs then administer NaBicarb

Front 35

MEN 2a

Back 35

medullary thyroid CA, pheo parathyroid hyperplasia

Front 36

MEN 2b

Back 36

medullary thyroid CA, pheo, and mucosal neuromas

Front 37

SE of high dose Beta2 agonist in asthma treatment

Back 37

hypokalemia that manifest as muscle weakness, arrhythmias and EKG abnormalities

other SE of beta agonists include tremor, palpitations, and headache

Front 38

MCCs of cirrhosis

Back 38

chronic alcohol abuse and viral hepatitis

Front 39

which murmurs to investigate and how

Back 39

new diastolic and continuous murmurs
loud systolic murmurs
investigate with echo

Front 40

desired pO2 in ARDS on vent

Back 40

50-60% by adjusting the FiO2

Front 41

factorial study design

Back 41

study that randomizes different interventions by looking at least 2 variables

Front 42

Bartter's syndrome

Back 42

defect in Na reabsorption in the thick ascending loop
hypokalemia, metabolic alkalosis, normal BP
elevated urine chloride

Front 43

risk of IV acyclovir

Back 43

as used in HCV encephalitits, it can crystallize in the urine
treatment is aggressive IV hydration

Front 44

cerviofacial actinomycosis treatment

Back 44

treatment is high dose IV PCN for 6-12 weeks

Front 45

Osler-Weber-Rendu syndrome

Back 45

autosomal dominant disorder with diffuse telangiectasias, recurrent epistaxis, and AVMs

the AVMs lead to hemoptysis and increased HCT

Front 46

drug of choice for CAP inpt vs. outpt.

Back 46

inpt: levoflozacin or moxifloxacin (cipro coverage is bad)
outpt: azithro or doxy

Front 47

what can soften S1 s/p MI

Back 47

mitral regurg due to papillary muscle rupture

Front 48

s/s of cerebellar hemorrhage

Back 48

ataxia, n/v, occitpital HA, gaze palsy, and facial weakness
NO hemiparesis

Front 49

indications for hypothyroid test on lab results

Back 49

HLD, hypoNa, and elevated serum muscle enzymes

Front 50

TCA overdose and the QRS

Back 50

prolong the QRS
NaBicarb shortens QRS by increasing extracellular Na