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16 Cards in this Set
- Front
- Back
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changes in uterus in normal cycle
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glands are mitotical active and circular during proligerative phases and tortuous during secretory phase
stroma prominent and mitotically active during prol phase during secretory phase prog prevents stroma from shedding, the cells look pseudodecidualized during secretory phase, |
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changes in uterus in pregnancy
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cytoplasm of stromal cells increases and is deeply eosinophilic, due to progesterone
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changes in uterus in postmenopause
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endometrial mucosa is thin
endometrial glands are scant and atrophic, small and mitotically inactive stroma is dense but thin |
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causes of endometritis
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acute: bacterial infxn usually postpartum or postabortal
chronic: nonspecific, infxn, trauma, |
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causes of dysfunctional uterine bleeding
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hormonal derangements (anovulation is the most common cause)
characteristically occurs at menarche and at menopause |
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what is an endometrial polyp
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common and benign but can result in bleeding, cystically dilated glands, fibrotic stroma, thick waled bv
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what factors make hyperplasia a risk for developing endometrioid carcinoma
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excessive estrogen
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typical presentation for a woman with endometrioid carcinoma
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4th most frequent cause of cancer
obesit, nulliparity, late menopause, chronic anovulation, unopposed estrogen replacement theraply, tamoxifen therapy 75% postmenopausal at presentation typically obese or chronic anovulation |
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how is endometrioid carcinoma graded and staged
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Grade: well differentiated 1, poor 3
Stage: based on depth of myometrial invasion and number of LN involved |
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what is usual clinical behavior of endometrioid carcinoma and UPSC
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based on histologic type, grade, and stage
75% present with stage 1, 90% 5yrs EC is potentially curable if caught early, UPSC is aggressive and has a poor prognosis |
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What is adenomyosis
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endometrial glands and stroma within the myometrium
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How common are leiomyomas
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most common neoplasm in women (25% of premonopausal women)
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What is the histologic appearance of leiomyoma
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histo: interlacing bundles of uniform smooth muscle cells
gross: well circumscribed, sperical, dense, wholrled, tan white benign, but can get realy big, cause bleeding, infertility |
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What is usual clinical behavior of leiomyosarcoma
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RARE, MALIGNANT, METASTASIZE (lung, liver, brain)
grossly simiar to meiomyoma, but with foci of hemorrhage and necrosis histo: cytoligic atypica, mitotic actibity, necrosis |
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what is malignant mixed mullerian tumor (MMMT)
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polypoid mass arising from endometrium but protruding through cervical canal
histo: mix of adenocarcinoma (malignant glands), malignant mesenchymal appearing compenents (leiomyo, rhabdomyo, osteao, stromal sarcomas) |
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Who gets MMMT and what is the clinical progression
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elderly women
aggressive tumor with poor prognosis (30% 5 yr) often presents high stage |
