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16 Cards in this Set

  • Front
  • Back
changes in uterus in normal cycle
glands are mitotical active and circular during proligerative phases and tortuous during secretory phase
stroma prominent and mitotically active during prol phase
during secretory phase prog prevents stroma from shedding, the cells look pseudodecidualized during secretory phase,
changes in uterus in pregnancy
cytoplasm of stromal cells increases and is deeply eosinophilic, due to progesterone
changes in uterus in postmenopause
endometrial mucosa is thin
endometrial glands are scant and atrophic, small and mitotically inactive
stroma is dense but thin
causes of endometritis
acute: bacterial infxn usually postpartum or postabortal
chronic: nonspecific, infxn, trauma,
causes of dysfunctional uterine bleeding
hormonal derangements (anovulation is the most common cause)
characteristically occurs at menarche and at menopause
what is an endometrial polyp
common and benign but can result in bleeding, cystically dilated glands, fibrotic stroma, thick waled bv
what factors make hyperplasia a risk for developing endometrioid carcinoma
excessive estrogen
typical presentation for a woman with endometrioid carcinoma
4th most frequent cause of cancer
obesit, nulliparity, late menopause, chronic anovulation, unopposed estrogen replacement theraply, tamoxifen therapy
75% postmenopausal at presentation
typically obese or chronic anovulation
how is endometrioid carcinoma graded and staged
Grade: well differentiated 1, poor 3

Stage: based on depth of myometrial invasion and number of LN involved
what is usual clinical behavior of endometrioid carcinoma and UPSC
based on histologic type, grade, and stage
75% present with stage 1, 90% 5yrs
EC is potentially curable if caught early,
UPSC is aggressive and has a poor prognosis
What is adenomyosis
endometrial glands and stroma within the myometrium
How common are leiomyomas
most common neoplasm in women (25% of premonopausal women)
What is the histologic appearance of leiomyoma
histo: interlacing bundles of uniform smooth muscle cells
gross: well circumscribed, sperical, dense, wholrled, tan white
benign, but can get realy big, cause bleeding, infertility
What is usual clinical behavior of leiomyosarcoma
RARE, MALIGNANT, METASTASIZE (lung, liver, brain)
grossly simiar to meiomyoma, but with foci of hemorrhage and necrosis
histo: cytoligic atypica, mitotic actibity, necrosis
what is malignant mixed mullerian tumor (MMMT)
polypoid mass arising from endometrium but protruding through cervical canal
histo: mix of adenocarcinoma (malignant glands), malignant mesenchymal appearing compenents (leiomyo, rhabdomyo, osteao, stromal sarcomas)
Who gets MMMT and what is the clinical progression
elderly women
aggressive tumor with poor prognosis (30% 5 yr) often presents high stage