Usyd Block 6 (Neuro) - Drug Quiz

Front 1

Glyceryl trinitrate

Back 1

Autonomic dysreflexia - (Nitric oxide vasodilation)

Front 2

Captopril

Back 2

Autonomic dysreflexia - (ACE inhibitor)

Front 3

acetazolamide

Back 3

Glaucoma, seizures, pseudotumor cerbri - (carbonic anhydrase inhibitor, decreases production of CSF (only in choroid))

Front 4

phenytoin

Back 4

antiepileptic - (enhance voltage gated Na+ channel inactivation --> reduces high frequency firing of Aps)

Front 5

carbamazepine

Back 5

antiepileptic - (enhance voltage gated Na+ channel inactivation --> reduces high frequency firing of Aps)

Front 6

lamotrigine (lamactil)

Back 6

antiepileptic - (enhance voltage gated Na+ channel inactivation --> reduces high frequency firing of Aps)

Front 7

ethosuxamide (zarontin)

Back 7

general absence seizures (mainly) - (T-type Ca2+ channel blocker)

Front 8

Sodium valproate

Back 8

antiepileptic, bipolar - (Na+ channel inactivator, Ca2+ channel blocker, increases GABA lvls)

Front 9

Vigabatrin

Back 9

antiepileptic - (strutural analogue of GABA, irreversibly binds to GABA transaminase and inhibts it)

Front 10

Tiagabine

Back 10

antiepileptic - (Mech 5 - Inhibit GABA Reuptake)

Front 11

memantine

Back 11

Alzheimers (moderate to severe) - (NMDA Rc antagonist)

Front 12

Dizocilpine
Dextrorphan

Back 12

Stroke (neuroprotective to penumbra of) - (glut Rc antagonist,)

Front 13

Lubeluzole, Riluzole

Back 13

Stroke (neuroprotective to penumbra of) - (voltage gated Na+ channel blockers)

Front 14

nimodipine, lifarizine

Back 14

Stroke (neuroprotective to penumbra of) - (voltage gated Ca2+ channel blockers)

Front 15

Tirilazad

Back 15

Stroke (neuroprotective to penumbra of) - (free radical scavenger)

Front 16

Dipyridamole

Back 16

Pts with hx of stroke - (thromboxane (A2) synthetase inhibitor)
usually used in combination with aspirin

Front 17

Acyclovir

Back 17

HSV and VZV infection - (Anti-viral)

Front 18

Ergotamine

Back 18

migraine - (constriction of intracranial extracerebral blood vessels via 5HT1B and inhibiting neurotransmission 5HT1D Rcs)

Front 19

Triptans

Back 19

migraines, cluster headaches - (agonised 5HT1B and 5HT1D receptors brain blood vessels)

Front 20

Perindopril

Back 20

HT, CAD, heart failure - (Long acting ACE inhib)

Front 21

Indapimide

Back 21

HT, Decompensated HF - (thiazide diuretic)

Front 22

Mannitol

Back 22

raised ICP, head trauma - (osmotic diuretic, cannot be reabsorbed in kidney and draws water out osmoticly)

Front 23

Dexamethasone

Back 23

- (25x more potent than cortisone, 7x prednisone)

Front 24

Prednisone

Back 24

- ()

Front 25

Propoxyplene

Back 25

analgesia - ()

Front 26

Naproxen

Back 26

pain, inflammation - (inhibiting both the COX-1 and COX-2 enzymes)

Front 27

Amitriptyline

Back 27

Antidepressant, Headache (Tension) - (TCA)

Front 28

Natalizumab (aka tysabri)

Back 28

MS - (mAb against α4 integrin leukocyte adhesion molecule)

Front 29

Glatiramer

Back 29

MS - (decoy, resemble MBP and might sequester the T cells. Apparentyl shifts th1 cells to Th2)

Front 30

Fingolimod

Back 30

MS - (Sequesters lymphocytes in lymphnodes)

Front 31

Methylprednisolone

Back 31

- (GCS like effects)

Front 32

L-DOPA

Back 32

PD and dsytonias - (crosses BBB readily and is converted by dopa decarboxylase to dopamine)

Front 33

Carbidopa

Back 33

PD and dsytonias - (Dopa-decarboxylase inhibitor)

Front 34

Benserazide

Back 34

PD and dsytonias - (Dopa-decarboxylase inhibitor)

Front 35

Bromocriptine

Back 35

PD, hyperprolactinaemia - (non-selective dopamine agonist which activates both D1-like and D2-like receptors)

Front 36

Apomorphine

Back 36

PD - (Dopamine Rc agonist - preferred in clinical practice)

Front 37

Pergolide

Back 37

PD - (Dopamine Rc agonist)

Front 38

Cabergoline

Back 38

PD, prolactinomas - (Dopamine Rc agonist)

Front 39

Domperidone

Back 39

PD, antiemetic - (Dopamine Rc Antagonist (D2))

Front 40

Doxepin

Back 40

depression, insomnia, anxiety - (Antidepressant (tricyclic), anxiolytic)

Front 41

Selegiline

Back 41

PD, depression, dementia - (MAOB inhibitor, used in combination with levadopa)

Front 42

Rasagiline

Back 42

PD - (MAOB inhibitor)

Front 43

Entacapone

Back 43

PD - (COMT inhibitor)

Front 44

Stalevo

Back 44

PD - (Combination preparation of L-Dopa, carbidopa and Entacapone)

Front 45

Pramipexole

Back 45

PD , RLS - (Dopamine Rc agonist (preferred in clinical practice))

Front 46

Amantidine

Back 46

Parkonsin's Disease, dyskinesias - (usually anti-viral, likely mechanism is release of dopamine from nerve terminals, non selective NMDA antagonist)

Front 47

Lithium

Back 47

Mood disorders - ()

Front 48

Clozapine

Back 48

schizophrenia - (binds 5HT and DA Rcs)

Front 49

Olanzapine

Back 49

schizophrenia, bipolar - (5HT2 and D2 Rcs antaongist)

Front 50

Donepezil

Back 50

Alzheimers (symptomatic only) - (acetylcholinesterase inhibitor)

Front 51

Galantamine

Back 51

Alzheimers (symptomatic only) - (acetylcholinesterase inhibitor)

Front 52

Clioquinol

Back 52

Antifungal / Antiprotozoal that is Neurotoxic
Possible Huntington's Rx
(Chelator of Cu and Zn)

Front 53

Gingko biloba

Back 53

Dementia - (increase blood supply, decrease viscosity, decrease free radicals)

Front 54

Rivastigmine

Back 54

Alzheimers - (acetylcholinesterase inhibitor)

Front 55

metronidazole

Back 55

Antibacterial and antiprotozoa - ()

Front 56

Quetiapine

Back 56

schizophrenia, bipolar and depression (in some cases) - (DA, 5HT and Adr antagonist)
Tradename Seroquel

Front 57

imipramine

Back 57

mood disorders - (TCA)

Front 58

Tricyclic antidepressants

Back 58

mood disorders - (inhibition of 5HT and NAd reuptake)

Front 59

Moclobemide

Back 59

depression and anxiety - (MAOI (no increase in blood pressure with tyramine containing food ingestion))

Front 60

SSRIs

Back 60

depression - (inhibiton of 5HT reuptake)

Front 61

Oxazepam

Back 61

anxiety - (benzo mechanism)

Front 62

Alprazolam

Back 62

Anxiety - (benzo mechanism)

Front 63

Buspirone

Back 63

Anxiety - (Non-benzo anxiolytic, high affinity for 5HT1A Rcs)
azapirone class - for GAD

Front 64

Flumazenil

Back 64

benzo overdose - (antagonises action of positive and negative modulators)

Front 65

Chlopromazine

Back 65

typical antipsychotic - (phenothiazine gorup, D2 Rc blocker)

Front 66

thioridazine

Back 66

typical antipsychotic - (phenothiazine gorup, D2 Rc blocker, )

Front 67

Haloperidol

Back 67

typical antipsychotic - (Butyropherone group, D2 Rc blocker.)

Front 68

Rispiridone

Back 68

atypical antipsychotic - (antagonise D2 Rcs, high affinity for 5HT rcs, effect on both +ve and -ve symptoms)

Front 69

aripiprazole

Back 69

atypical antipsychotic - (antagonise D2 Rcs, high affinity for 5HT rcs, effect on both +ve and -ve symptoms))