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7 Cards in this Set
- Front
- Back
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What is this drug?
- binds ergosterol and disrupt fungal membrane. |
- Amphotericin B: toxicity (hypotension, nephrotoxicity, arrhythmia, anemia, phlebitis).
- Nystatin |
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What is this drug?
- inhibit ergosterol synthesis |
azoles
- toxicity: hormone synthesis inhibition (gynecomastia), liver dysfunction (inhibition of P450) |
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What is this drug?
- inhibit DNA synthesis by cinversion to fluorouracil, which competes with uracil |
flucytosine
- toxicity: bone marrow suppression |
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What is this drug?
- inhibit cell wall synthesis |
capsofungin
- treats invasive aspergilosis - toxicity: GI, flushing |
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What is this drug?
- inhibit fungal enzyme squalene epoxidase |
terbinafine
- treats dermatophytoses |
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What is this drug?
- interferes with microtubule function, disrupts mitosis - deposits in keratin containing tissues (nails) |
griseofulvin
- treats dermatophytes (tinea, ringworm) - toxicity: teratogenic, increase P450 and warfarin metabolism |
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Treatment for oral cadidiasis.
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- topical nystatin
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