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10 Cards in this Set

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Nephrotic syndrome: sudden onset flank pain and gross hematuria, left-side variocele. What does urinary lost related with this condition?
Antithrombin III. renal cein thrombosis
what is pseudopalisading necrosis?
foci of necrosis surrounded by tumor cells. pseudopalisading necrosis with peipheral angiogenesis are characteristic of glioblastoma multiforme (GBM)
African form of Burkitt lymphoma
1. translocation of the c-myc oncogene on the q8 with Ig heavy chain region on chromosome 14 [t(8,14)]. c-myc is a transcription activator controlling cell proliferation, differentiation and apoptosis.
2.associatived with EBV infection
3.consists of monomorphic, intermediated-sized lymphocytes with round nuclei, interspersed macrophage surrounded by clear spaces (starry sky)
myotonic muscular dystrophy
1. 2nd most common inherited muscular disorder. (Duchenne muscle dystrophy is the most mommon)
2. autosomal dominant trait, trinucleotide repeat expansion(CTG) of the myotonia-protein kinase gene. increasingly severe disease in each generation (anticipation).
3. myotonia (sustained muscle contraction), cataracts, frontal balding, gonadal atrophy.
4. type 1 fibers are more affected.
What does positive VDRL of the spinal fluid indicate?
neurosyphilis.
Tabes dorsalis: demyelination of the dorsal columns, loss of vibratory and position sense, stumbling at night, ataxia, Argyll Robertson pupil
antibody of Goodpasture syndrome
α3 chain of collagen type IV
vessel medial band-like calcification
Monckeberg's medial calcific sclerosis, or medial calcinosis. clinically asymptonatic, do not narrow the vessel lumen
colon adenocarcinoma development
1. progression from normal mucosa to a small polyp: APC tumor suppressor gene mutation.
2. increase polyp size: mutation of K-ras (leading to uncontrolled cell proliferation)
3. malignant transformation of adenoma to carcinoma: 2 gene mutation: p53 and DCC
abnormal bleeding in uremia patient
qualitative platelet disorder with normal platelet count, PT and PTT. Bleeding time is prolonged.
what add to the blood of hemophilia patient results in clotting?
thrombin