Usmle Step I: Metabolism

Front 1

Site of metabolic process:
Fatty acid oxidation

Back 1

Mitochondria

Front 2

Site of metabolic process: Acetyl CoA production

Back 2

Mitochondria

Front 3

Site of metabolic process:
Krebs Cycle

Back 3

Mitochondria

Front 4

Site of metabolic process:
Oxidative Phosporylation

Back 4

Mitochondria

Front 5

Site of metabolic process:
Glysolysis

Back 5

Cytoplasm

Front 6

Site of metabolic process:
Fatty acid synthesis

Back 6

Cytoplasm

Front 7

Site of metabolic process:
HMP Shunt

Back 7

Cytoplasm

Front 8

Site of metabolic process:
Protein synthesis

Back 8

Cytoplasm

Front 9

Site of metabolic process:
Steroid synthesis

Back 9

Cytoplasm

Front 10

Site of metabolic process:
Heme synthesis

Back 10

Mitochondria and Cytoplasm

Front 11

Site of metabolic process:
Urea Cycle

Back 11

Mitochondria and Cytoplasm

Front 12

Site of metabolic process:
Gluconeogenesis

Back 12

Mitochondria and Cytoplasm

Front 13

Rate determining enzyme of:
De novo pyrimidine synthesis

Back 13

Aspartate transcarbamylase (ATCase)

Front 14

Rate determining enzyme of:
De novo purine synthesis

Back 14

Glutamine PRPP amidotransferase

Front 15

Rate determining enzyme of:
Glycolysis

Back 15

Phosphofructokinase (PFK-1)

Front 16

Rate determining enzyme of:
Gluconeogenesis

Back 16

Pyruvate carboxylase

Front 17

Rate determining enzyme of:
TCA cycle

Back 17

Isocitrate dehydrogenase

Front 18

Rate determining enzyme of:
Glycogen synthesis

Back 18

Glycogen synthase

Front 19

Rate determining enzyme of:
Glycogenolysis

Back 19

Glycogen phosphorylase

Front 20

Rate determining enzyme of:
HMP Shunt

Back 20

Glucose-6-phosphate dehydrogenase (G6PD)

Front 21

Rate determining enzyme of:
Fatty acid synthesis

Back 21

Acetyl-CoA carboxylase (ACC)

Front 22

Rate determining enzyme of:
Fatty Acid Oxidation

Back 22

Carnitine acetyltransferase I

Front 23

Rate determining enzyme of:
Ketogenesis

Back 23

HMG CoA synthase

Front 24

Rate determining enzyme of:
Cholesterol synthesis

Back 24

HMG CoA reductase

Front 25

Rate determining enzyme of:
Heme synthesis

Back 25

ALA synthase

Front 26

Rate determining enzyme of:
Urea cycle

Back 26

Carbamoyl phosphate synthase I

Front 27

Function of glucokinase:

Back 27

Phosphorylates excess glucose to sequester it in the liver

Front 28

Most potent activator of phosphofructokinase:

Back 28

F2, 6BP

Front 29

End products of pyruvate metabolic pathways and their function:

Back 29

1. Alanine (carries amino groups to liver from muscle)

2. Oxaloacetate (replenish TCA cycle or be used in gluconeogenesis)

3. Acetyl CoA (transition from glycolysis to TCA cycle)

4. Lactate (end of anaerobic glycolysis--major pathway in RBC's, leukocytes, kidney medulla, lens testes, cornea)

3.

Front 30

What is the function of the Cori cycle?

Back 30

Allows lactate generated during anaerobic metabolism to undergo hepatic gluconeogenesis and become a source of glucose for RBCs and muscle.