Usmle Step 1 - May 21 & 22 (Immunology)

Front 1

What disease(s) is a/w HLA subtype A3?

Back 1

Hemochromatosis

Front 2

What disease(s) is a/w HLA subtype B27?

Back 2

PAIR
- Psoriasis
- Ankylosing spondylitis
- IBD
- Reiter's/Reactive Arthritis

Front 3

What disease(s) is a/w HLA subtype B8?

Back 3

Grave's Dz

Front 4

What disease(s) is a/w HLA subtype DR2?

Back 4

MS
SLE
Goodpasture's
Hay fever (allergies)

Front 5

What disease(s) is a/w HLA subtype DR3?

Back 5

DM1

Front 6

What disease(s) is a/w HLA subtype DR4?

Back 6

DM1
RA

Front 7

What disease(s) is a/w HLA subtype DR5?

Back 7

Pernicious Anemia (& B12 def)
Hashimoto's thyroiditis

Front 8

What disease(s) is a/w HLA subtype DR7?

Back 8

Steroid-responsive Nephrotic Syndrome

Front 9

Which are the live attenuated vaccines?

Back 9

Sabin (Polio)
Yellow Fever
MMR
Chicken Pox (Varicella)

I'm SABIN' a lot of $ by going to the YMC-A

Front 10

Which are the killed / inactivated vaccines?

Back 10

- Cholera
- HAV
- Influenza
- Rabies
- Polio (SALK)

you won't hear a CHIRP (or a SULK) outta them

Front 11

What marker is used to detect mast cell degranulation (for e.g. in an anaphylactic reaction)?

Back 11

Tryptase = serine protease

Front 12

What disorder is a/w anti-Smith Ab's?

Back 12

SLE

Front 13

What disorder is a/w Antihistone Ab's?

Back 13

Rx-induced Lupus

Front 14

What disorder is a/w Anti-IgG Ab's?

Back 14

RA

(="rheumatoid factor")

Front 15

What disorder is a/w Anticentromere Ab's?

Back 15

Scleroderma (CREST)

Front 16

What disorder is a/w Anti-DNA topoisomerase I?

Back 16

Scleroderma (diffuse)

(=Anti-Scl-70)

Front 17

What disorder is a/w Antimitochondrial Ab's

Back 17

PBC

Front 18

What disorder is a/w Antiendomysial Ab's?

Back 18

Celiac disease

Also Antigliadin

Front 19

What disorder is a/w Anti-BM Ab's?

Back 19

Goodpasture's syndrome

Front 20

What disorder is a/w Anti-desmoglein Ab's?

Back 20

Pemphigus vulgaris

Front 21

What disorder is a/w Antimicrosomal Ab's?

Back 21

Hashimoto's thyroiditis

Also Antithyroglobulin

Front 22

What disorder is a/w Anti-Jo-1?

Back 22

Polymyositis
Dermatomyositis

Front 23

What disorder is a/w Anti-SS-A and Anti-SS-B Ab's?

Back 23

Sjogren's syndrome

A = Ro
B = La

Front 24

What disorder is a/w Anti-U1 RNP?

Back 24

Mixed Connective Tissue Disease (MCTD)

RNP = ribonucleoprotein

Front 25

What disorder is a/w Anti-Smooth Muscle?

Back 25

Autoimmune hepatitis

Front 26

What disorder is a/w Anti-glutamate decarboxylase?

Back 26

DM 1

Front 27

What disorder is a/w c-ANCA?

Back 27

Wegener's Granulomatosis

cytoplasmic-AntiNeutrophil Cytoplasmic Ab

Front 28

What disorder is a/w p-ANCA?

Back 28

Vasculitides:
- Mycroscopic Polyangitis
- Churg-Strauss

Front 29

What bacteria are you most susceptible to if you are lacking complement?

Back 29

Neisseria

b/c there's no Membrane Attack Complex (MAC)

Front 30

What infections are you prone to w/ agranulocytosis?

Back 30

Bacteria = Staph & Pseudomonas

Fungi = Candida & Aspergillus

Front 31

What is aldesleukin used for?

Back 31

It's an IL-2 analog used for:
- RCC
- Metastatic Melanoma

Front 32

What is Filgrastim used for?

Back 32

Granulocyte colony stimulating factor analog (GCSF)

Stimulates Bone Marrow (post chemo)

Front 33

What is Sargramostim used for?

Back 33

Granulocyte macrophage colony stimulating factor analog

used for Bone marrow stimulation (following chemo)

Front 34

What diseases is IFN-α used to Tx?

Back 34

HBV
HCV
KS
AML & CML
Malignant Melanoma

Front 35

What disease is IFN-ß used to Tx?

Back 35

MS

Front 36

What disease is IFN-Γ used to Tx?

Back 36

CGD

Front 37

What recombinant cytokines are sued to treat Thrombocytopenia?

Back 37

Thrombopoeitin
Oprelvekin (IL-11 analog)

Front 38

Which mab's target TNF-α and what is their application?

Back 38

Infliximab
Adalimumab

Tx the Seronegative Spondylarthropathies & RA

NOT Reactive Arthritis

NOTE: Inflix = only for AS

Front 39

What is the target for Abciximab?

Back 39

G IIb/IIIa

Prevents cardiac ischemia in:
- Unstable angina
- Percutaneous coronary interventions

Front 40

What is the target of Trastuzumab?

Back 40

aka HERceptin

Targets erb-B2

Used to tx HER-2 overexpressing breast cancers

Front 41

What is the target of Rituximab?

Back 41

CD20 (expressed on B-Cells)

Tx for B-cell NHL

Front 42

What is the target for Omalizumab?

Back 42

IgE

Used for severe asthma

Front 43

What are the calcineurin inhibitors and what are they used for?

Back 43

Cyclosporine
Tacrolimus

Inhibit IL2 and used in post-transplant and autoimmune diseases

VERY nephrotoxic!`

Front 44

How is mTOR involved in immunosuppression?

Back 44

Sirolimus = Rapamycin

Forms a complex w/ FKBP12 and blocks mTOR.

This prevents TCell's from responding to IL-2 secretion.

Front 45

What mab's are useful in transplant immunosuppression?

Back 45

Daclizumab = Dac-LI-2-umab
- binds IL2-R
Muromonab = OKT3
- binds CD3