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85 Cards in this Set
- Front
- Back
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Morning stiffness lasting longer than an hour
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Spondyloarthropathy(inflammatory back pain)
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pain that is relieved by rest
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Osteoarthritis
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pain that is not relieved by rest or position change
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metastatic bone cancer
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constant pain, present at rest and exacerbated by motion
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Vertebral osteomyelitis
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antiphospholipid antibodies is a synonym for?
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Lupus anticoagulant or anti-cardiolipin antibodies
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Most common cause of prolongued PTT
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lupus anticoagulant, anti-cardiolipin or antiphospholipid antibodies
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Hyper homocysteinuria is characterized as a...what kind of clinical state?
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Pro-thrombotic/Hypercoagulable
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Word association for "migratory thrombophlebitis"
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cancer
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Trousseau's Syndrome
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Migratory thrombophlebitis that is a/w visceral adenocarcinomas(pancreas mostly, also colon, lung though)
characterized by |
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What deficiency is diagnostic of Paroxysmal Nocturnal Hematuria?
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deficiency of CD55 and CD59
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biopsy may not show abnormal findings in this vasculitis
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Giant Cell Temporal Arteritis
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linear appearance of glomeruli on IF
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Goodpasture
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c-ANCA positive
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Wegener's
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anti-glomerular basement membrane
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Goodpasture's
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interstitial lung disease and kidney involvement
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Wegener's and/or Goodpasture
Wegeners is c-ANCA Goodpasture is anti-glomerular basement membrane |
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Microangiopathic Hemolytic Anemia
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Anemia WITH consumption of platelets but NOT coag factors(normal PT/PTT)
TTP or HUS |
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Gastrointestinal Blood loss leads to what type of anemia?
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Iron Deficiency anemia
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Where in the kidney is O2 sat sensed?
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Peritubular Renal Cells in the renal cortex
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fatty streaks on the inner surface of aorta
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everyone has this finding, foamy macrophages due to lipid accumulation(engulfed LDL)
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Sickle cell does what to spleen
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causes it to fibrose and shrink
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Most common cause of iron deficiency anemia
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blood loss
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propensity for hemarthroses
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Hemophilia
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vasodilator and platelet aggregation inhibitor
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prostacyclin
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back pain not relieved by rest or position change is indicative of
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neoplasm
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commonly presents as urinary hesitancy, nocturia, frequency and hematuria
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prostate cancer
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morning stiffness longer than an hour
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Inflammatory Back pain(spondylopathy)
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Seronegative Spondylopathies
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PAIR
Psoriatic Arthritis Ankylosing spondylitis(most common) Inflammatory Bowel Disease Reactive Arthritis |
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Seronegative Spondylopathies strongly associated with what?
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HLA-B27(codes for MHC I)
PAIR |
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"pencil in a cup" x-ray imaging
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psoriatic arthritis
dactylitis(sausage fingers) |
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pain during activity that can be relieved by rest and NSAIDS
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osteoarthritis
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back pain that is constant, present at rest and is exacerbated by motion
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Vertebral osteomyelitis
a/w fever |
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prostate cancer has a predilection to metastasize where?
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axial skeleton
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DVT, cerebral vein thrombosis and recurrent pregnancy loss
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Factor V leiden mutation
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major causes of splenic infarction
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sickle cell anemia, infectious endocarditis, myeloproliferative disorders
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common manifestation of anemias
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heart palpitations, fatigue
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Hematologic Malignancies such as lymphoma, multiple myeloma and leukemia have what kind of anemia
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normocytic, normochromic
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Dermatitis, Diarrhea, Dementia
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The 3 D's of pellagra(niacin deficiency/B3)
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Commonly affected organs by malignant HTN
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kidneys, retinas, intestinal arterioles
doesn't usually involve muscle |
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Clinically Silent vascular abnormality
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Monckeberg Arteriolosclerosis - calcification in media
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Atheromas
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Lipid filled intimal plaques that bulge into lumen of artery
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Wegener's affects which layer of vessel?
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Granulomas in Media
Giant Cell Temporal Arteritis also has granulomas in media |
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Claudication is? caused by?
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muscle pain produced by exercise. Caused by atherosclerosis due to atheromas
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pathognomonic for PNH
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CD55/CD59 deficiency
DAF/MIRL which inhibit complement |
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intrasplenic lipid accumulation can be seen in?
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Gaucher Disease - Lysosomal Lipid Storage disease
Glucocerebrosidase |
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most common cause of aPTT elevation
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anti-phospholipid antibodies
(lupus anticoagulant, anti-cardiolipin) |
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A bone marrow biopsy of greater than 30% plasma cells diagnostic for?
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Multiple Myeloma
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osteoclast activating factor
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IL-1
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Multiple myeloma associated cytokines
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IL-1, IL-6
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"starry sky"
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Burkitt Lymphoma
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Sickle Cell Trait complication
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inability to concentrate urine, hematuria
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Urokinase MOA
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activates plasminogen
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Thrombocytopenia occurs in the setting of liver disease because...?
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Hypersplenism
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elevated serum ACE levels with restrictive lung disease
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Sarcoidosis - Chronic Restrictive Granulomatous Lung Disease
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pulmonary involvement in Goodpasture syndrome causes
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hemoptysis
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Antibodies for Scleroderma
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Anti-Scl70 or Anti-centromere
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Pulmonary involvement in Scleroderma causes...
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Chronic Restrictive Interstitial Fibrosis
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Eosinophilia and elevated IgE/IgG antibodies with asthma-like symptoms
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Allergic Bronchopulmonary Aspergillosis
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segmental fibrinoid necrosis
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microscopic polyangiitis in small vessels
PAN in larger vessels |
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immune complex, plasma proteins, complement and smudgy eosinophilic deposits
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fibrinoid necrosis
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Buerger Disease Synonym
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Thromboangiitis Obliterans
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Reticulocyte count low in? High in?
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Low in aplastic anemia
high in hemolytic, hemorrhagic anemia |
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Elevated LDH presents in
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hemolytic anemia
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Most common nephrotic syndrome in children
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nephrotic --> proteinuria
Minimal Change Disease....treat with Steroids |
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Microangiopathic Hemolytic Anemia classic presentations
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adults -- CNS symptoms
children -- renal involvement |
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A/w MAP-kinase signal transduction system
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Ras
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Decreases risk for ovarian cancer...
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birth control, multiparity and breast feeding
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Anti-mitochondrial antibodies are seen in...
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Primary Biliary Cirrhosis
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Major cause of AAA
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atherosclerosis arising from intimal streaks which are due to lipids leaking into intima where foamy macrophages pick up the LDL's
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Synonym for Osler-Weber-Rendu Syndrome
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hereditary hemorrhagic telangiectasia
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von Recklinghausen's disease synonym?
presentation? |
NF-1
peripheral nervous system tumor with development of... neurofibromas(Schwann Cell origin) Optic Nerve Gliomas Lisch Nodules Cafe Au Lait spots |
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Lisch Nodules stain positive for...
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S-100 and vimentin
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NF-2 presentation?
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bilateral cranial nerve VIII schwanommas and multiple meningiomas
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Encephalotrigeminal Angiomatosis
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Sturge-Weber syndrome
Port-wine stain with ipsilateral Angioma Calcification of brain on x-ray on ipsilateral side of port-wine stain leptomeningeal angioma |
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von-Hippel Lindau disease
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Capillary Hemangioblastoma's in the retina or cerebellum
congenital cysts or neoplasms on kidney, liver and pancreas |
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von-Hippel lindau disease puts you at increased risk for?
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Renal Cell Carcinoma(bilateral)
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Tuberous Sclerosis
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kidney, liver and pancreatic cysts
CNS involvement with subependymal HAMARTOMAS other symptoms-- adenoma sebaceum(cutaneous angiofibromas) visceral cysts cardiac rhabdomyoma renal angiomyolipoma SEIZURES |
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t(9;22)
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CML
ALL(b-cell) |
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t(8;14)
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Burkitt
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t(14;18)
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Follicular Lymphoma
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Kartagener a/w
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microtubular defect
situs inversitus |
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Friedrich's Ataxia a/w
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hypertrophic cardiomyopathy
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neural input to sweat glands
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pre and post ganglionic neuron release ACh
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neural input to adrenal glands
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single neuron releases ACh
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t(12;21)
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good prognosis b-cell ALL
in contrast to t(9;22) |
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subependymal
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area around ventricles with adult stem cells
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