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15 Cards in this Set
- Front
- Back
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Block cell wall synthesis by inhibition of peptidoglycan cross-linking
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Penicillins
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Name three antibiotics that inhibit peptidoglycan synthesis?
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Bacitracin, vancomycin, cycloserine
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Blocks mRNA synthesis?
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Rifampin
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Bactericidal antibiotics?
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Penicillin,cephalosporins,vancomycin, aminoglycosides, fluoroquinolones, metronidazole
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Disrupt bacterial/fungal cell membranes
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polymyxins
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Disrupt fungal cell membranes
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Amphotericin B, nystatin, fluconazole/azoles
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Block DNA topoisomerases
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Quinolones
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Block nucleotide synthesis
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sulfonamides, trimethoprim
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Blocks protein synthesis at 30S ribosomal subunit?
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Aminoglycosides and tetracyclines
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Blocks protein synthesis at 50S ribosomal subunit?
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Chloramphenicol, erythromycin/macrolides, linomycin, clindamycin, streptogramins, linezolid
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Which penicillin if delivered IV? and Oral?
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Penicillin G (IV)
Penicillin V (Oral) |
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Toxicity of penicillin?
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Hypersensitivity and hemolytic anemia
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Three penicillins resistant to penicillinase due to bulkier R group?
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Methicillin, nafcillin, dicloxacillin (oxacillin group)
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This penicillin (resistant to penicillinase) has been known for causing interstitial nephritis?
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Methicillin
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Three mechanisms of penicillin?
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1. Binds penicillin binding proteins
2. Blocks transpeptidase enzyme 3. Activates autolytic enzymes |
