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15 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Chlorothiazide
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Inhibit Na+ reabsorption in DCT via inhibition of Na/Cl cotransporter
Rely on renal function for efficacy Increased excretion of Na and Cl; Loss of K+, Ca2+, and Mg2+ |
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Chlorothalidone
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Thiazide-like diuretics
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Hypertension
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Hydrochlorothiazide
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Inhibit Na+ reabsorption in DCT via inhibition of Na/Cl cotransporter
Rely on renal function for efficacy Increased excretion of Na and Cl; Loss of K+, Ca2+, and Mg2+ |
Hypertension; heart failure; hypercalciuria; diabetes insipidus
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Indapamide
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Thiazide-like diuretics
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Antihypertensive effects with minimal diuretic action, esp. in advanced renal failure
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Metolazone
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Thiazide-like diuretics
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Causes Na+ excretion in advanced renal failure
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Bumetanide
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Inhibit cotransport of the Na/K/2Cl transporter in ALH
Most efficacious of diuretics due to 25-30% of Na+ reabsorption that occurs in ALH Also, causes decreased renal vascular resistance and increased renal blood flow |
Acute pulmonary edema of HF, esp. in emergent situations; hypercalcemia (requires concurrent hydration therapy); hyperkalemia
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Ethacrynic acid
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Inhibit cotransport of the Na/K/2Cl transporter in ALH
Most efficacious of diuretics due to 25-30% of Na+ reabsorption that occurs in ALH Also, causes decreased renal vascular resistance and increased renal blood flow |
Acute pulmonary edema of HF, esp. in emergent situations; hypercalcemia (requires concurrent hydration therapy); hyperkalemia
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Furosemide
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Inhibit cotransport of the Na/K/2Cl transporter in ALH
Most efficacious of diuretics due to 25-30% of Na+ reabsorption that occurs in ALH Also, causes decreased renal vascular resistance and increased renal blood flow |
Acute pulmonary edema of HF, esp. in emergent situations; hypercalcemia (requires concurrent hydration therapy); hyperkalemia
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Torsemide
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Inhibit cotransport of the Na/K/2Cl transporter in ALH
Most efficacious of diuretics due to 25-30% of Na+ reabsorption that occurs in ALH Also, causes decreased renal vascular resistance and increased renal blood flow |
Acute pulmonary edema of HF, esp. in emergent situations; hypercalcemia (requires concurrent hydration therapy); hyperkalemia
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Amiloride
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Block Na+ channels in collecting ducts, independent of aldosterone
Often used in conjunction with other diuretics |
Diuretic (DOC in hepatic cirrhosis); secondary hyperaldosteronism; heart failure
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Eplerenone
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Competitively antagonizes the intracellular aldosterone receptor
Increases Na+ excretion and promotes retention of K+ and H+ Often used in conjuction with other diuretics |
Diuretic (DOC in hepatic cirrhosis); secondary hyperaldosteronism; heart failure
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Spirinolactone
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Competitively antagonizes the intracellular aldosterone receptor
Increases Na+ excretion and promotes retention of K+ and H+ Often used in conjuction with other diuretics |
Diuretic (DOC in hepatic cirrhosis); secondary hyperaldosteronism; heart failure
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Acetazolamide
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Inhibits reabsorption of bicarbonate in the PCT via inhibition of luminal carbonic anhydrase
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Open-angle glaucoma; Mountain sickness
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Mannitol
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Osmotic diuretic
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Increased ICP; ARF due to shock, Rx toxicity, or trauma
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Urea
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Osmotic diuretic
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Increased ICP; ARF due to shock, Rx toxicity, or trauma
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