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53 Cards in this Set
- Front
- Back
Oncogene: c-myc
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Burkitt's lymphoma
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Oncogene: bcl-2
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follicular and undifferentiated lymphomas (inhibits apoptosis)
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Oncogene: erb-B2
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breast, ovarian, and gastric carcinomas
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Oncogene: ras
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colon carcinoma
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Oncogene: L-myc
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lung tumor
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Oncogene: N-myc
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neuroblastoma
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Oncogene: ret
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multiple endocrine neoplasia (MEN) types II and III
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Tumor Suppressor gene: Rb
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13q, retinoblastoma, osteosarcoma
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Tumor Suppressor gene: BRCA1 and 2
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17q, 13q, breast and ovarian cancer
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Tumor Suppressor gene: p53
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17p, most human cancers, Li Fraumeni syndrome
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Tumor Suppressor gene: APC
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5q, colorectal cancer (adenomatous polyps and colon cancer)
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Tumor Suppressor gene: WT1
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11q, Wilms' tumor
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Tumor Suppressor gene: NF1
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17p, neurofibromatosis type 1
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Tumor Suppressor gene: NF2
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22q, neurofibromatosis type 2
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Tumor Suppressor gene: DPC
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18q, colon cancer
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Tumor Suppressor gene: DCC
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18q, colon cancer
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Tumor Marker: PSA
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prostate-specific antigen, prostatic carcinoma, used for screening
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Tumor Marker: CEA
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carcinoembryoic antigen, nonspecific, but produced by 70% of colorectal and panc cancers, also produced by gastric and breast carcinomas
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Tumor Marker: alpha-fetoprotein
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normally made by fetus, hepatocellular carcinomas, nonseminomatous germ cell tumors of the testis (e.g. yolk sac tumor)
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Tumor Marker: beta-hCG
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Hydatidiform moles, Choriocarcinomas, and Gestational trophoblastic tumors
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Tumor Marker: CA-125
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ovarian, malignant epithelial tumors
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Tumor Marker: S-100
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melanoma, neural tumors, astrocytomas
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Tumor Marker: alkaline phosphatase
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metastases to bone, obstructive biliary disease, Paget's disease of bone
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Tumor Marker: Bombesin
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neuroblastoma, lung and gastric cancer
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Tumor Marker: TRAP
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tartrate-resistant acid phosphatase, hairy-cell leukemia--a B cell neoplasm
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HTLV-1
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(adult) human t-cell leukemia virus
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HBV, HCV
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hepatocellular carcinoma
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EBV
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Burkitt's lymphoma, nasopharyngeal carcinoma
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HPV
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cervical carcinoma (types 16, 18), penile/anal carcinoma
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HHV-8
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= Kaposi's sarcoma-associated herpesvirus, Kaposi's sarcoma, body cavity fluid B-cell lymphoma
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Aflatoxins
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liver (hepatocellular carcinoma), toxic compounds produced by mold, ex. in peanuts
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vinyl chloride
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liver (angiosarcoma), flammable gas used in plastics industry
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Nitrosamines
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esophagus, stomach, in various products, tobacco, others
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Asbestos
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lung (mesothelioma and bronchogenic carcinoma), used in fire-proof insulation
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Arsenic
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skin (squamous cell carcinoma), in insecticides, weed killers
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CCl4
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liver (centrilobular necrosis, fatty change), in fire extinguishers and dry cleaning fluid
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naphthalene (aniline) dyes
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bladder (transitional cell carcinoma)
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Associated neoplasm? Down syndrome
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ALL (we ALL fall DOWN)
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Associated neoplasm? Xeroderma pigmentosum Albinism
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Melanoma, Basal cell carcinoma, Squamous cell carcinoma (skin)
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Associated neoplasm? Chronic atrophic gastritis, Pernicious anemia, Post surgical gastric remnants
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Gastric adenocarcinoma
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Associated neoplasm? Tuberous slcerosis (facial angiofibroma, seizure, mental retardation)
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Astocytoma, Angiomyolipoma, Cardiac rhabdomyoma
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Associated neoplasm? Actinic keratosis
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Squamous cell carcinoma (skin)
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Associated neoplasm? Barrett's esophagus (chronic GI reflux)
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Esophageal adenocarcinoma
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Associated neoplasm? Plummer-Vinson syndrome (atrophic glossitis, esophageal webs, anemia - all due to iron deficiency)
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Squamous cell carcinoma (esophagus)
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Associated neoplasm? Cirrhosis (alcoholic, Hep B or C)
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Hepatocellular carcinoma
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Associated neoplasm? Ulcerative colitis
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Colonic adenocarcinoma
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Associated neoplasm? Paget's disease of bone
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Secondary osteosarcoma, Fibrosarcoma
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Associated neoplasm? Immunodeficiency states
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Malignant lymphomas
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Associated neoplasm? AIDS
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Aggressive malignant lymphomas (non-Hodgkin's), Kaposi's sarcoma
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Associated neoplasm? Autoimmune diseases (Hashimoto's thyroditis, myasthenia gravis)
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Benign and malignant lymphomas
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Associated neoplasm? Acanthosis nigricans (hyperpigmentation and epidermal thickening)
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Visceral malignancy (stomach, lung breast, uterus)
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Associated neoplasm? Dysplastic nevus
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Malignant melanoma
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Associated neoplasm? Radiation exposure
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Sarcoma
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