Usmle Immunology And Pathology High Yield Vignettes

Front 1

Patient with mycoplasma pneumoniae exhibits cryoagglutinins during recovery phase. What type of immunoglobulins are reacting?

Back 1

IgM

Front 2

Young child presents with tetany and candidiasis. What immune cell is deficient?

Back 2

T-cell (DiGeorge)

Front 3

Young child has recurrent lung infections and granulomatous lesions. What enzyme is deficient in neutrophils?

Back 3

NADPH oxidase (chronic granulomatous disease)

Front 4

Patient presents with recurrent Neisseria infections. What complement proteins are deficient?

Back 4

C6-C8

Front 5

Woman complains of malar rash and arthritis. The presence of which antibodies are specific for SLE?

Back 5

Anti-dsDNA
Anti-Smith

Front 6

Patient presents with dermatitis, enteritis and hepatitis after bone marrow transplantation. What disease process is occurring?

Back 6

Graft vs. Host disease

Front 7

Prostate Biopsy shows neoplastic proliferation of well-differentiated glands with evidence of tumor spread to regional lymph nodes. What is the Gleason score and stage of prostate cancer?

Back 7

Low Gleason (low grade)
High Stage

Front 8

Boy presents with mental retardation, facial angiofibromas and seizures. What type of cancers are most often associated with this disease?

Back 8

Cardiac rhabdomyomas and astrocytomas (in tuberous sclerosis)

Front 9

Patient with marked leukocytosis and the presence of myeloid blast cells in the peripheral blood is found to have lymphandenopathy and splenomegaly. What oncogene most likely became translocated in the myeloid stem cells?

Back 9

abl (to form bcr-abl)

Front 10

Mother notices that her daughter has a white pupil, which later is confirmed to be inherited retinoblastoma. Her daughter has an increased risk of what other type of cancer?

Back 10

Osteosarcoma (Rb tumor supressor gene)

Front 11

Woman's pap smear shows dysplastic changes. What HPV types are most often associated with cervical carcinoma?

Back 11

Types 16 and 18

Front 12

Man complains of joint pain following chemotherapy for AML. What is the side effect of his cancer treatment?

Back 12

Increased nucleic acid turn over from dying cancer cells leads to hyperuricemia (tumor lysis syndrome)

Front 13

Elderly woman on chronic hemodialysis treatment has a biopsy of her joint spaces that shows amyloid deposits. From what protein is the amyloid derived?

Back 13

Beta 2- microglobulin