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11 Cards in this Set
- Front
- Back
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IL-1
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-Secreted by macrophages
-causes acute inflammation -Chemokine production to recruit leukocytes -activates endothelium to express adhesion molecules. -an endogenous pyrogen |
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IL-2
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-Secreted by Th cells
-stimulates growth of helper and cytotoxic T cells |
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IL-3
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-Secreted activated T cells
-Supports the growth and differentiation of bone marrow stem cells -Has a function similar to GM-CSF |
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IL-4
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-Secreted by TH2 cells
-Promotes growth of B cells -Enhances class switching to IgE and IgG |
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IL-5
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-Secreted by TH2 cells
-Promotes differentiation of B cells -Enhances class switching to Ig! -Stimulates production and activation of eosinophils |
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IL-6
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-Secreted by Th cells and macrophages
-Simulates production of acute-phase reactants and immunoglobulins |
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IL-8
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-secreted by macrophages
-Major chemotactic factor for neutrophils |
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IL-10
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Secreted by regulatory T cells
-Inhibits actions of activated T cells -Activates Th2 and inhibits Th1 |
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IL-12
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Secreted by B cells and macrophages
-activates NK and Th1 cells |
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y-interferon
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Secreted by Th1 cells
-Stimulates macrophage -Activates Th1 -Inhibits Th2 |
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TNF
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Secreted by macrophages
-mediates septic shock -causes leukocyte recruitment, vascular leak |
