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14 Cards in this Set

  • Front
  • Back
Clones of proliferating antigen-specific B-Cells are called
Germinal Centers
minor idiotype changes that lead to greater affinity for antigen is called
Somatic Hypermutation
Clonal seletion by competition fo antigen leads to
affinity maturation
This cell determines switch region activation in B-Cells
Th2 cells
This Ig type is used as a measure of a primary response (acute infection)
IgM
Convaslecent serum will have mostly this type of Ig
IgG with subthreshold levels of IgM
Isotype switching is induced by the following interactions (3) btwn B-cells and this other type of cell
1. MHCII/peptide presentation
2. Costimulatory molecules (B7)
3. CD40/CD40L binding

This is mediated by TH2 cells.
Thymus-independent antigens are characterized by:
1. Contain no peptides
2. Stimulate only IgM
3. Create no memory
While it is not an opsonin, this Ig isotype is most effective at activating complement
IgM

Also it doesn't mediate ADCC
___ cells arise from precursor when a strong innate immune response is stimulated, while ___ cells arise in the absence of such responses
Th1 when strong innate immune response present.
Th2 when absent
CD__+ Treg inhibit ___ cell function by secretion of
CD25+ Treg secrete IL-10 inhibiting TH1 cell function
TH1 cells produce (3):
1. IFN-Gamma--| TH2 cells
2. TNF-Beta
3. IL-2
TH2 cells produce (6):
1. IL-4
2. IL-5
3. IL-6
4. IL-10
5. IL-13
6. TGF-Beta

"Always and 4Ever"
IL-5-->IgA class switch
IL-4-->IgE and IgG class switch and inhibit Th1 cells
Memory B lymphocytes differ from naive B cels in that they have undegone ___ and express
isotype switching

and express IgE,IgG, IgA in their membranes.