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14 Cards in this Set
- Front
- Back
Clones of proliferating antigen-specific B-Cells are called
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Germinal Centers
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minor idiotype changes that lead to greater affinity for antigen is called
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Somatic Hypermutation
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Clonal seletion by competition fo antigen leads to
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affinity maturation
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This cell determines switch region activation in B-Cells
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Th2 cells
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This Ig type is used as a measure of a primary response (acute infection)
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IgM
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Convaslecent serum will have mostly this type of Ig
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IgG with subthreshold levels of IgM
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Isotype switching is induced by the following interactions (3) btwn B-cells and this other type of cell
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1. MHCII/peptide presentation
2. Costimulatory molecules (B7) 3. CD40/CD40L binding This is mediated by TH2 cells. |
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Thymus-independent antigens are characterized by:
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1. Contain no peptides
2. Stimulate only IgM 3. Create no memory |
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While it is not an opsonin, this Ig isotype is most effective at activating complement
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IgM
Also it doesn't mediate ADCC |
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___ cells arise from precursor when a strong innate immune response is stimulated, while ___ cells arise in the absence of such responses
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Th1 when strong innate immune response present.
Th2 when absent |
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CD__+ Treg inhibit ___ cell function by secretion of
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CD25+ Treg secrete IL-10 inhibiting TH1 cell function
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TH1 cells produce (3):
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1. IFN-Gamma--| TH2 cells
2. TNF-Beta 3. IL-2 |
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TH2 cells produce (6):
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1. IL-4
2. IL-5 3. IL-6 4. IL-10 5. IL-13 6. TGF-Beta "Always and 4Ever" IL-5-->IgA class switch IL-4-->IgE and IgG class switch and inhibit Th1 cells |
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Memory B lymphocytes differ from naive B cels in that they have undegone ___ and express
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isotype switching
and express IgE,IgG, IgA in their membranes. |