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60 Cards in this Set
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Sensitivity

TP/(TP+FN)
Probability that a person having a disease will be correctly identified 

Specificity

TN/(TN+FP)
Probability that a person who doesn't have a disease will be correctly identified 

PositivePredictive Value

TP/(TP+FP)
Probability that an individual who tests (+) has the disease 

NegativePredictive Value

TN/(TN+FN)
Probability that a person who tests () doesn't have the disease 

Prevalence

TP+FN/(total # in study)
Total number of cases in a population at a given time 

Incidence

# new cases each year/*susceptible* population
(ex: In a population of 100, there are 10 new cases of cat scratch fever every year. The prevalence of CSF in this population is 20. Therefore, the *incidence* of CSF in this population is 10/80) 

Relative Risk

Used in cohort studies.
(TP/TP+FP)/(FN/FN+TN) 

Odd Ratio

Used in casecontrol studies
(TP x TN)/(FPxFN) 

Mean

average


Median

Middle value in sequentially ordered groups of #'s


Mode

# that appears most often in a group


Positive skew

peak is to the left
mean>median>mode 

Negative skew

peak is to the right
mean<median<mode 

When prevalence decreases, sensitivity and specificity are...

unchanged


When prevalence decreases, what happend to PPV and NPV?

PPV decreases and NPV increases


HardyWeinberg population genetics equation

If "p" and "q" are different alleles, then:
p2+2pq+q2=1 or p+q=1 

Heterozygote frequency for
HW population genetics 
HF=2pq


HendersonHasselbalch

pH=pKa + log[A]/[HA]


How to convert logs

log (base 10) a = x
or 10x = a 

Volume of distribution

Vd = (amount of drug in body)/(plasma drug concentration)


Drug clearance (1 of 4)

CL = (rate of drug elimination)/(plasma concentration of drug)


Drug clearance (2 of 4)

CL = Ke x Vd


Drug clearance (3 of 4)

CL = (0.7 x Vd)/t1/2


Drug clearance (4 of 4)

CL = Infusion rate/(steady state concentration)


Half life (1 of 2)

t1/2 = (0.7 x Vd)/CL


Half life (2 of 2)

t1/2 = 0.7/Ke


Therapeutic index

TI = LD50/ED50


Loading dose

LD = (Cp x Vd)/F
F=bioavailability 

Maintainence dose

MD = (Cp x CL)/F


Infusion rate

IR = CL x steady state conc.


Cardiac output (1 of 3)

CO = (rate of O2 consumption)/(arterial O2 content  venous O2 content)


Cardiac output (2 of 3)

CO = SV x HR


Cardiac output (3 of 3)

CO = MAP/TPR


Mean arterial pressure (1 of 2)

MAP = CO x TPR


Mean arterial pressire (2 of 2)

MAP = 1/2 systolic + 2/3 diastolic


Stroke volume (1 of 2)

SV = CO/HR


Stroke volume (2 of 2)

SV = end diastolic volume  end systolic volume


Ejection fraction

EF = (SV/EDV) x 100


Glomerular filtration rate (1 of 2)

GFR = (Uinulin x V)/(Pinulin)


Glomerular filtration rate (2 of 2)

GFR = FF x RPF


GFR is equal to clearance of *what* and is close enough to the clearance of *what else*?

GFR = inulin clearance
GFR ~ creatinine clearance 

Effective renal plasma flow

ERPF = (Upah x V)/(Ppah)


Effective renal plasma flow is equal to the clearance of *what*?

ERPF = pah clearance


Renal blood flow

RBF = RPF/(1Hct)


Renal plasma flow (1 of 2)

RPF = RBF x (1Hct)


Renal plasma flow (2 of 2)

RPF = GFR/FF


Free water clearance

Ch2o = V  Cosm


How do you get total body water from total body weight?

total body water is generally 60% of a man's total body weight and 50% of a woman's


How do you measure intracellular fluid (ICF)?

ICF = TBW  extracellular fluid (ECF)
ICF is about 2/3 TBW 

How do you measure ECF?

inulin, mannitol, sulfate


How do you measure plasma?

It's about 1/4 ECF
(or, whatever was measured with evan's blue) 

How do you measure interstitial fluid?

IF = ECF  plasma volume
IF is about 3/4 the ECF 

Vital capacity

VC = TV + IRV + ERV


Functional reserve capacity

FRC = RV + ERV


Inspiratory capacity

IC = IRV + TV


Total lung capacity

TLC = IRV + TV + ERV + RV


i love equations gone Wild!

yee haw!


confidence interval of the mean

CI = mean +/ Z(S/sqrt(N))
For a 95% CI, Z=1.96. Make it 2 for convenience's sake. 

Series resistance

Rt = R1+R2+R3...


Parallel resistance

1/Rt = 1/R1+1/R2+1/R3...
