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43 Cards in this Set

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DOC for long-term obesity management

MOA

(2) AE
Orlistat

(Inhibits pancreatic lipases)

AE:
Steatorrhea,
GI pain
Drug that acts as a short and long-term obesity management

MOA

(2) AE
Sibutramine

(Serotonin and NE reuptake inhibitor)

AE:
Tachycardia,
HTN
Inhibits thyroid hormone synthesis and decreases peripheral conversion of T4 -> T3

(3) AE
Propylthiouracil (PTU)

AE:
Aplastic anemia,
skin rash,
Agranulocytosis (rare)
DOC for Turner's syndrome
Somatostatin

(also GH deficiency)
What (4) disorders does Octreotide (somatostatin analog) treat?
"C 8 (Oct) GAG":

Carcinoid,

Gastrinoma,

Acromegaly,

Glucagonoma
Tx for Central DI
Desmopressin
Tx for Hypothyroidism

(3) AE
Levothyroxine, Triiodothyronine

AE:
Tachycardia,
Heat intolerance,
Tremors
(4) Dx that use Glucocorticoids as Tx

AE?
Addisons Dz,

Inflammation,

Immune supression,

Asthma

AE: Iatrogenic Cushing's syndrome
A 5-alpha-reductase inhibitor used to Tx BPH and promote hair growth*
Finasteride
BurryPenHere: Fine-ass-to-ride
a Non-steroidal competitive inhibitor of androgens at the testosterone receptor to Tx prostate CA
Flutamide
Tx PCOS
Oral birth control
(2) drugs that inhibit steroids and are used in PCOS to treat hirsutism
Ketoconazole,

Spironolactone
Inhibits cGMP phosphodiesterase causing Inc cGMP and smooth muscle relaxation in corpus cavernosum

(2) AE?
Sildenafil (or Vardenafil)

AE:
headache,
blue-green vision
(head throbs w/ blue balls)
what drug is both an agonist and antagonist to GnRH?
(explain)

Use for each?
Leuprolide

Pulsitile fashion: Agonist
(Infertility)

Continuous: Antagonist
(prostate cancer)
Partial agonist at estrogen receptors in pituitary gland.

Use?

AE?
Clomiphene
(prevents Neg feedback to increase LH and FSH)

Use:
Stimulate Ovulation (infertility Tx)

AE:
Ovarian enlargement, multiple preg
Competitive inhibitor of Progestins at progesterone receptor

Use?

(2) AE?
Mifepristone (RU-486)

Abortifacient (prevents implantation)

AE:
Heavy bleeding,
GI upset
greatest AE of oral contraception
Hypercoagulable state
Tx for hormone replacement therapy and Osteoporosis
(2)
Raloxifene
(SERM),

Estrogen/Progesterone therapy
for contraception, what is in Oral, Depo and an implant?
Oral: E2/P4 combo

Depo: Medroxyprogesterone

Implant: Norgestrel
DOC for Breast CA w/ estrogen receptors

AE?
Tamoxifen
(SERM)

AE: Endometrial hyperplasia
what drug class has AE of Acne, decreased HDL, depression, hirsutism, weight gain
Progestins
Drug that activates E2 receptors in Endometrium and blocks them in Breast
Tamoxifen
Drug that activates E2 receptors in bone and blocks them in Breast and Endometirum
Raloxifene
DOC for reduction of bone resorption and increasing new bone formation
Alendronate

(bisphosphonate)
MOA of Etidronate
Inhibition of the formation of Hydroxyapatite crystals
DOC for Padget's Dz
Calcitonin
what is the treatment for Tetany following a thyroidectomy?
Calcium gluconate
What drug is useful in testing endocrine function?
How?

MOA
Metyrapone

Tests Pituitary-adrenal axis:

Inhibits 11b-OH
how do glucocorticoids work as anti-inflammatory and immunosupressive drugs?
Reduce capillary permeability and edema at the inflam site and prevent PMNs from entering interstitial space
DOC to inhibit Prolactin release
Bromocriptine
Rapid onset insulin form
Lispro
(2) Maintenance forms of insulin (peak 4 - 12 hrs)
NPH,

Lente
Longest acting insulin
Glargine
MOA of Sulfonylureas
blocks K+ channels in Beta cell causing opening of Ca channels, releasing insulin from storage vesicles
DOC for Rickets or any Vit-D deficiency

MOA
Calcitrol

(enhances intestinal absorption of calcium)
DOC androgen derivative for Endometriosis
Danazol

(monitor LFTs)
Dx:

postmenopausal female develops weakness, polyuria and polydipsia; also mild acidosis and nephrocalcinosis
Hypervitaminosis D

(too much Vit-D)
MOA of PTU
Inhibition of Thyroidal Peroxidase
what drug inhibits, by acting as a competitor, the accumulation of Iodide in thyroid follicular cells?
Potassium Perchlorate
what is the Tx for Graves Dz in pregnent woman?
PTU
Steroid derivative that promotes the synthesis of factors II, VII, IX and X and may interfere w/ effects of Warfarin or result in thromboemboli?
Ethinyl Estradiol
steroid to help promote lung maturity
Betamethasone
Drug that lowers serum calcium from cancers
Plicamycin