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39 Cards in this Set

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Catalyzes the activation of antithrombin III to decrease thrombin and Xa

Uses (2)

site of action?
Heparin


Uses:
Immediate anticoagulation
(PE, MI, stroke, DVT),
Used during pregnancy (does not cross)

site: Blood
Interferes w/ factors II, VII, IX and X and protein C and S

Use

site of action?
Warfarin

use:
Chronic coagulation

[the EX-PaTriot went to WAR]
EXtrinsic-PT pathway

site: Liver
drug class that aids in conversion of plasminogen to plasmin (which cleaves thrombin and fibrin clots)

name (4)
Thrombolytics

Streptokinase,
Urokinase,
tPA (alteplase),
Antistreplase
what inhibits plasminogen to plasmin?
Aminocaproic acid
what glycoprotein in platelet binds to exposed collagen?

which bind together to aggregate?
to collagen: GP-1a


together: GP-IIb/IIIa
The only irreversible binder in the group to inhibit COX-1 and COX-2
Aspirin
drug inhibits platelet binding by irreversibly blocking ADP receptors, thereby inhibiting fibrinogen binding by preventing GP-IIb/IIIa expression

(2) uses

AE?
Clopidogrel

use:
Acute Coronary syndrome,
Coronary stenting

AE:
Neutropenia
(tiCLOPidine)
drug that binds directly to GP-IIb/IIIa on activated platelets, preventing aggregation

use?
Abciximab


use:
Angioplasty
S-phase specific anti-cancer drugs
(5)
Methotrexate,
5-FU,
Cytarabine,
6-MP,
Hydroxyurea
S-phase antimetabolite that inhibits DHF reductase resulting in low dTMP

(2) AE?
Methotrexate


AE:
Myelosuppression,
Macrovesicular fatty liver
what reduces the myelosuppression toxicity in Methotrexate?
Leucovorin
S-phase pyrimidine analog that inhibits thymidylate synthase, resulting in low dTMP

(3) uses

(2) AE
5-Fluorouricil (5-FU)

uses:
Colon CA,
solid tumors,
Basal cell CA

AE:
Myelosuppression,
photosensitivity
S-phase that blocks Purine synthesis and is activated by HGPRTase

(2) uses?

what can increase toxicity?
6-Mercaptopurine (6-MP)

use:
Leukemias (not CLL)
Lymphomas (not Hodgkin)

inc Toxicity: Allopurinol
(metabolized by Xanthine Oxidase)
S-phase tha inhibits DNA polymerase to compete w/ dCTP

use?

(3) AE
Cytarabine (ARA-C)

use: AML

AE:
Leukopenia,
Thrombocytopenia,
Megaloblastic anemia
Alkylating agent covalently x-link DNA at guanine N-7

use (3)

AE
Cyclophosphamide

use:
Non-Hodgkins lymphomas,
Breast CA,
Ovarian CA

AE:
hemorrhagic CYSTITIS
Alkylating agent class that crosses BBB

name drugs (2)

AE
Nitrosoureas

drugs:
"-MUSTINE"
Streptozocin

AE:
CNS toxicity (dizzy, ataxia)
(2) anti-cancer drugs that act like Alkylating agents and form free radicals; they cause AE of Ototoxicity and Nephrotoxicity

use (4)
Cisplatin, Carboplatin

use (BOLT):
Bladder CA,
Ovarian CA,
Lung CA,
Testicular CA,

[BOLT ON the PLAnTation]
Alkalaying agent of DNA used as DOC for CML

(2) AE
Busulfan

AE:
Pulmonary fibrosis,
hyperpigmentation
(2) anti-cancers that generates free radicals and noncovalently intercalate in DNA (breaking strands); AE include cardiotoxicity

(2) uses

another AE
Doxorubicin (Adriamycin),
Danorubicin

use:
Hodgkins (A in ABVD combo)
solid tumors

AE:
Alopecia
another name for:

Doxorubicin
Adriamycin
what anti-cancer drug that intercalates in DNA, is used for childhood tumors?
ACTinomycin-D

[children ACT out]
drug that induces formation of free radicals to cause breaks in DNA; AE is pulmonary fibrosis

(2) uses
Bleomycin

use:
Testicular CA,
Hodgkins (B in ABVD combo)
G2-specific agent that inhibits Topoisomerase-II

(3) uses
EToPoSide (VP-16)

uses:
T: Testicular CA,
P: Prostate CA,
S: Small cell CA of lung
MC glucocorticoid in cancer therapy

(2) uses

aside from usual corticoid AE (cushings, osteoporosis) what other AE?
Prednisone

use:
Hodgkins (P in MOPP combo)
CLL

AE:
cataracts
monoclonal Ab against HER-2 (erb-B2)--Breast CA

AE
Trastuzumab (HERceptin)

AE:
Cardiotoxicity
monoclonal Ab against the Philadelphia chromosome brc-abl tyrosine kinase
Gleecec (Imatinib)
M-phase specific alkaloids that bind to tubulin and block polymerization of microtubules so that spindle fibers cannot form

use (3)

AE (2)
Vincristine ("Oncovin"); Vinblastine

use:
Hodgkins (O in MOPP combo),
Wilm's Tumor,
Choriocarcinoma

AE:
Vincristine - Neurotoxicity
Vinblastine - BLASTs bone marrow
M-phase specific that bind to tubulin and hyperstabilize polymerized microtubules so that spindle fibers cannot breakdown (anaphase cant occur)

use (2)

AE (2)
Taxols (Paclitaxel)

use:
Ovarian CA
Breast CA

AE:
myelosuppression,
Hypersensitivity
what are the drugs in the ABVD Hodgkins combo?
Adriamycin (doxorubicin),
Bleomycin,
Vinblastine,
Dacarabazine
what are the drugs in the MOPP Hodgkins combo?
Mechlorethamine
Oncovoin (Vincristine)
Prednisone
Procarbazine
DOC for CLL
Prednisone
DOC in CML
(2)
Gleevac,

Busulfan
DOC in AML
Cytarabine
anti-cancer drug that causes Pancreatitis
Asparaginase
anti-cancer drug that causes oral and GI ulcers
5-FU
which ant-cancer drugs are clasified as Alkylating agents?
(4)*
"at NITe the CYCLOne picked-up the BUS and CAR"

NITrosureas,
CYCLOphosphamide,
BUSulfan,
CARboplatin, cisplatin
at NITe the CYCLOne picked-up the BUS and CAR
what anti-cancer drug works in the G-0 phase?
Busulfan
which anti-cancer drugs generate free radicals?
(3)*
BAD radicals:

Bleomycin,
Actinomycin-D,
Doxorubicin, Daunorubicin
BAD radicals
(2) drugs that work in the G-2 phase
Bleomycin,

Etoposide (VP-16)