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140 Cards in this Set

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Anitschlow myocytes : reactive histiocytes
Rheumatic fever
Apple-green bifringence
Amyloidosis
Aschoff bodies : fibrinoid necrosis surrounded by multinucleated giant cells
Rheumatic fever
Asteroid bodies : flower-like spores at end of hyphae
Sporothrix schenckii
Dx:
Asteroid bodies -
stellate inclusions w/i multinucleated giant cells
(2)
- Noncaseating granuloma
- Sarcoidosis
Atypical lymphocytes
(one disease cause and one drug)
- Mononucleosis
- Phenytoin
Auer rods : cytoplasmic inclusion rods in leukocyte
Acute promyelocytic leukemia (AML)
Basophillic stippling of RBCs
lead poisoning
Birbeck granules
histocytosis X (eosinophillic granuloma)
Blue dome cyst
fibrocystic disease of the breast
Branching septate hyphae @ 45°
Aspergilus
Bread and butter pericarditis
(4)
A PURrrr:
- Acute MI
- Pericarditis, fibrinous
- Uremia
- Rheumatic fever
Big, Broad-based budding
Blastomycosis
Budding yeast w/ pseudohyphae
Candida albicans
Bullet shaped capsid
Rabies
Call-Exnor bodies : rosette-like structure resembling an ovarian follicle
Granulosa cell tumor
Bug:
Captain's wheel
Paracoccidiomycosis

[PARAot on the Captain]
Catepillar cardiac myocytes in longitudinal section
Rheumatic fever
Charcot-Leyden crystals : refractile crystals seen in eosinophils
bronchial asthma
Chocolate cysts
endometriosis
Cigar shaped budding yeast
Sporothrix schencki
Clue cells : epithelial cells w adherent bacteria
Gardnerella vaginitis
Councilman bodies : eosinophillic inclusions w/i dying hepatocytes
Yellow fever
Crescents in Bowman's capsule
rapidly progressive [crescentic] glomerulonephritis
Darkfield microscopy
Treponemes
(Syphilis)
Dimorphic yeast sperules with endospores
Coccidioides immitis
Dohle bodies : dilated endoplasmic reticulum of PMN, appears as gray cytoplasmic inclusion
acute inflammation
Dx:
Donovan bodies - organism ladden histiocytes
Granuloma Inguinale
Epitheloid cells : epithelial looking cells on H&E
activated macrophages as in granulomas
Ferruginous bodies in lung
Asbestosis
Flea bitten kidney
Malignant HTN
Fried egg look
(2)
- Mycoplasma pneumoniae
- Oligodendroglioma
Fruiting bodies and 45 degree branching septate hyphae
Aspergillus
Crinkled paper-looking cell with enlarged cytoplasm
Gaucher's disease
Ground glass nuclei
Papillary CA of thyroid
Heavily encapsulated yeast
Cryptococcus neoformans
Heinz bodies : denatured hemoglobin
G6PDH deficiency
Helmet cell : deformed RBC
TTP
Hemolysis - alpha incomplete /green
(2)
Strep. Pneumoniae;

Viridians strep
Hemolysis - beta complete /clear
(3)
Strep. pyogenes;
Staph aureus;
Listeria
Hemolysis - gamma none
Enterococcus
Hemolysis - double zone
Clostridium perfringens
Hirano bodies : intracytoplasmic actin inclusions (eosinophilic rods)
Alzheimer's
Homer Wright rosettes : "small cells" surrounded by fibrillary processes
Neuroblastoma
Howell Jolly cells : RBCs w nuclear remnants
(2)
- Splenectomy
- Hgb SS
Hydatid sand :
broad capsule full of silicates
Echinococcosis
(sheep herder's disease)
Hypochromic Microcytic RBCs
iron deficiency anemia
Ito cell : stores vitamin A
Causes fibrosis of liver -> cirrhosis
Joint mice
Osteoarthritis
Keratin pearls
Squamous cell carcinoma
Kimmelstein-Wilson lesions : pink peripheral nodules of glomeruli
diabetic nephropathy
Koilocytes : expanded epithelial cells with perinuclear clearing
HPV
Lewy bodies : eosinophillic inclusions of ubiquinated neurofilaments in substantia nigra cells
Parkinson's
Lines of Zahn
arterial thrombus
Lumpy-bumpy IF glomeruli
poststreptococcal glomerulonephritis
Mallory bodies : intracytoplasmic eosinophillic inclusions of ubiquinated keraitn intermediate filaments
Alcoholic hepatitis
Masson bodies : clumps of Mac digested debris from lung
Bacterial pneumonia
Media - Bordet Gengou agar
bordetella pertussis
Media - Buffered charcoal yeast extract
legionella pneumophila
Media - charcoal blood agar with cephalexin
bordetella pertussis
Media - chocolate agar w/ V, X
H. influenza
Media - Eaton's agar
Mycoplasma pneumoniae
Media - EMB metallic green sheen
Escherichia coli
Media - Lowenstein-Jensen media
mycobacterium tuberculosis
Media - MacConkey [pink colonies]
(3)
MacConKEE:

- Klebsiella
- E.coli
- Enterobacter
Media - Mannitol salt agar
Staph aureus [ferments]from other staph
Media - Thayer-Martin chocolate agar
Neisseria
Bug:
Metachromatic granules
Corynebacteria diptheria
Motility on wet prep pear-shaped organisms
Trichomonas
Motility, Swarming
Proteus mirabilis
Motility, Tumbling
Listeria
Bug:
Mucoid capsule
Klebsiella
Multinucleated squamous cells w intranuclear inclusion
HSV
Negri bodies : eosinophilic, cytoplasmic inclusions in neurons
Rabies
Neuritic plaques
Alzheimer's
Neurofibrillary tangles : intracytoplasmic microtubule inclusions
Alzheimer's
Nissl bodies
rough ER [in neurons]
Nutmeg liver
Congestive Heart Failure
Orphan Annie nuclei : hypochromatic nuclei
Papillary carcinoma of thyroid
Owl's eye cardiac myocytes in cross section
Rheumatic fever
Owl's eye inclusions : nuclear inclusion surrounded by a halo
CMV
Peripheral Blood Smear - clock face chromatin
Plasma cell
Peripheral Blood Smear - frosted glass cytoplasm w/ kidney shaped nucleus
Monocyte
normal Peripheral Blood Smear - cells w/ granules & bilobate nucleus
(2)
- Basophil

- Eosinophil
Peripheral Blood Smear - Hypersegmented neutrophils
Megaloblastic anemia; B12 or folate deficiency
Peripheral Blood Smear - scant cytoplasm w/ round dense nucleus
Lymphocyte
round intracytoplasmic inclusions of neurofilaments
Pick's disease
Pigment - bilirubin
(3)
- Hemolytic anemia
- Hepatitis
- Gall stones
Pigment - Hemosiderin
(3)
- Hematochromatosis
- Left heart failure
- Anemia of chronic disease
Pigment - lipofuscin
Yellow-brown granular pigment of "wear-n-tear".
Pigment - Melanin
(2)
- ACTH overproduction (Addison's)
- Malignant melanoma.
Polygonal clear cells
Renal cell carcinoma
Psammoma bodies : calcified necrotic tumor cells
(3)
- Papillary CA
- Meningioma
- Mesothelioma
Pseudopalisades
Glioblastoma multiforme
Red inclusions in endocervical cells
Chlamydia
Red snappers on acid fast staining
Tuberculosis
Reed-Sternberg cells : binucleat cells w prominate inclusion like nucleoli
Hodgkin's Disease
Reid Index [increased]
chronic bronchitis
Reinke crystals in GU tissue
Leydig cell tumor
Rouleaux formation : RBCs stacked as poker chips
Multiple Myeloma
Schiller Duval bodies : papillary infoldings into cysts in GU tissue
Yolk sac tumor
Schistocyte
TTP
Signet ring cells : mucinous tumor cell
(2)
- Stomach cancer
- Ovarian mets from stomach tumor (Krukenberd tumor)
Smudge cell : fragile lymphocyte disrupted during slide prep.
CLL
Spaghetti and meatballs
Malassezia furfur
Spike and Dome IF glomeruli
Membranous glomerulonephritis
Spindle cells
(4)
Spin the F**** LOG!

- Fibrosarcoma
- Leiomyoma (fibroid)
- Osteosarcoma
- Giant cell tumor of bone
Spores
(3)
c.Perfringes,

Anthrax,

Tetani

(and fungi)
Stains - Ziehl-Neelsen
Mycobacteria

(Acid-fast bacteria)
Stains - Giemsa
(4)
- Trypanosomes
- Borrelia
- Plasmodium
- Chlamydia

(chromosome karyotyping)
Stains - India Ink
Cryptococcus neoformans
Starry sky
Burkitt's lymphoma [EBV]
Stomatocytes : RBCs w mouth
Alcoholism
Bug:
Sulfur granules
Actinomycosis [A. israelii]
Tear drop cells : mis-shapen RBCs
(2)
- Thalassemias
- Myelofibrosis
Target cells: bullseye
(2)
- Alcoholic Liver disease
- Thalassemias
Tennis rackets

(1 disease, 1 bug)
- Histiocytosis X
- Clostridium tetani
Tram-Track IF glomeruli
Membranoproliferative glomerulonephritis
Warthin-Finkeldey Giant cells
Measles
WBC casts
pyelonephritis
Weibel Palade bodies : granules contain vWF, adhesion molecules
nml in endothelial cells
Wire Loop IF glomeruli
Lupus nephropathy, type IV
Yeast w/ capsular halo
Cryptococcus neoformans
Stain - Silver
(3)
- Fungi
- PCP
- Legionella
Obligate intracellular bugs
(2)
- Rickettsia
- Chlamydia

(stay inside when its Really Cold)
Lactose fermenting
(3)
Lactose is the KEE
- Klebsiella
- E. coli
- Enterobacter
Bug:
Comma shaped
Campylobacter

(*grow @ 42 degrees)
RBC casts
(4)
MING casts a red sky...

- Malignant HTN
- Ischemia
- Nephritic syndromes
- Glomerular inflammation
Granular casts
Acute Tubular Necrosis
Waxy casts
Advanced renal disease (CRF)
RBCs in urine
Bladder cancer
WBCs in urine
Acute cystitis
Kidney has split basement membrane
Alport's syndrome
Rectal polyp w/ glands & sawtooth crypts
Hyperplastic Polyp
(normal--benign)
Buffered charcoal yeast extract
Legionella
Heterophile Ab test
EBV
Branch hyphae w/ rosettes of conidia
Sporothrix
Branch septate hyphae w/ athroconidia
Tinea pedis
KOH prep
mold hyphae
Short, curved hyphae w/ round yeast
Malassezia furfur
(Tinea vesicolor)