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10 Cards in this Set
- Front
- Back
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where urea cycle takes place |
liver, in cytoplasm and mitochondria |
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3 reaction that fix free ammonia |
1. Gluamate dehydrogenase alpha-KG to glu, add one NH3 2. glutamine synthetase glu to glutamine 3. CPS-1 NH3 and Co2/Hco3 |
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reactions that release ammonia (2) |
1. Glutamate dehydrogenase Glu to Alpha-KG 2. Glutaminase glutamine to glu |
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how ammonia is transported from muscle to other tissues |
as glutamine |
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1st urea cycle rxn |
NH3 and CO2/HCO3- to carbamoyl phosphate CPS-1 in mitochondria |
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2nd urea rxn |
carbamoyl phosphate to citrulline OTC in mitochondria |
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3rd urea rxn |
citrulline and aspartate to arginosuccinate arginosuccinate synthetase in cytoplasm |
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4th urea rxn |
argionsuccinate to fumarate and arginine arginosuccinate lyase in cytoplasm |
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5th urea rxn |
arginine to ornithine and UREA arginase in cytoplasm |
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Urea cycle regulation |
Glu becomes N-acetyl glutamate as Acetyl CoA becomes CoA regulates CPS-1 enzyme |
