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33 Cards in this Set
- Front
- Back
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What lymphoma is common in young adults?
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Hodgkin's Lymphoma
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What are the B symptoms?
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Fever over 100.4
Chills Night sweats Weight loss over 10% body weight |
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What size lymph node is considered pathologically enlarged?
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Over 1 cm
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What are the two main types of Hodgkin lymphoma?
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Nodular lymphocyte predominant
Classical |
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What are the diagnostic findings of Hodgkin lymphoma?
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Reed-Sternberg cell
Positive for CD30, CD15 |
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What are the morphologic subtypes of classic Hodgkin's?
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Nodular sclerosis
Mixed cellularity Lymphocyte rich Lymphocyte depleted |
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You can use an aspirate to diagnose lymphoma, true or false?
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False
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What tests are used to diagnose lymphoma?
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CT
PET Bilateral bone marrow biopsies |
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What is the chemo regimen for Hodgkins?
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ABVD
Adriamycin, Bleomycin, Vinblastine, Dacarbazine |
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What is the 5 year freedom from progression rate in Hodgkins?
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40-85%
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What is the most common low-grade non-Hodgkin lymphoma?
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Follicular lymphoma (22%)
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What is the median age for diagnosis of follicular lymphoma?
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60-70 years of age
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What are the findings on a blood smear of a patient with follicular lymphoma?
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Small cleaved cells
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What is found on flow cytometry in follicular lymphoma?
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CD20+
CD10+ bcl-2+ CD5- |
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What do follicular lymphoma cells consist of?
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Centrocytes - Small cleaved cells
Centroblasts - larger cells that divide more |
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A large number of centroblasts indicates what in follicular lymphoma?
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More aggressive
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The mantle zone, polarization of germinal center, and paracortex are lost in what lymphoma?
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Follicular lymphoma
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What translocation is found in 85% of patients with follicular lymphoma?
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t(14;18)
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MALT lymphoma makes up what percentage of primary gastric lymphomas?
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50%
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What infection is western MALT associated with?
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Chronic H.pylori infection
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Salivary gland MALT lymphoma can cause what?
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Sjogren's syndrome
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A MALT lymphoma in the GI tract can cause what?
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Crohn's disease
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A MALT lymphoma of the thyroid can cause what?
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Hashimoto's thyroiditis
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What is the treatment for MALT lymphoma
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Treat H.pylori
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Absence of t(11;18) is a good prognostic factor in what cancer?
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MALT lymphoma
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What is the percentage of remission in MALT lymphomas when H.pylori is treated?
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50-80%
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What is the fastest growing lymphoma?
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Burkitt's lymphoma
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What does African Burkitt's lymphoma affect?
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jaw, facial bone
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What does American Burkitt's lymphoma affect?
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lymph nodes in abdomen, GI tract
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What is the pattern finding in the bone marrow of a Burkitt's lymphoma patient?
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Starry sky pattern
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Many patients will present in renal failure in what lymphoma?
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Burkitt's lymphoma
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What test assesses how much cell turnover exists, and is often elevated in cancer patients?
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LDH
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What are the treatments for Burkitt's lymphoma?
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Complicated chemo
Radiation Transplant |
