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43 Cards in this Set

  • Front
  • Back
this links cognition with sex drive, sexual awareness, mood-emotion, and memory
interactive limbic pathways
what are the four primary sites of sexual differentiation
gonads
internal ducts
external genitalia
brain
gonad differentiation
occurs at 6-9 weeks
common primordia under genetic control
male begins by 6 weeks
in absence of Y chormosome ovaries develop at 7-9 weeks
function of the sex determining region on the Y chromosome (SRY gene)
causes testis to develop
internal genital ducts
diff. occurs at 8-12 wks
separate sets of primordia which transiently coexist in embryos of both sexes
maleness requires positive influences of
testosterone
mullerian inhibiting substance
absence of these yields mullerian (female) ducts
external genitalia
diff. at 8-12 wks
common primordia undergo continuous process
maleness requires + effect of DHT alone
when androgen effect is intermediate, newborn shows partial virilization
diff. is virtually complete by 16th week
masculinization will never occur if T is not present in
the first 12 weeks of gestation
genetic females with excess androgens may have
complete phallic urethra and prostatic tissue
what enzyme is needed for this reaction to occur T --> DHT
5alpha-reductase
Bipotential hypothalamic neurons in absence of androgens
GnRH pulsing
LH surge
bipotential hypothalamic neurons in presence of androgens
no GnRH pulsing or LH surge
LH surge can be elicited in
women and homosexual men, but not in heterosexual men
surge in women is much larger than gay men
psychosexual diff.
occurs at 8-12 wks and postnatal
it appears that androgen presence during sexual diff. favors but does not determine development of masculine sexuality and the androgen absence during sexual diff. favors but does not determine development of feminine sexuality
these factors influence how the prenatal input is expressed in adults
genetic predisposition
postnatal experiences
gender role and gender ID
adrenogenital women, despite being corrected in infancy show these tendencies
increased bisexual and homosexual fantasies
chornically elevated cortisol (stress) does what to the male fetus
supresses testosterone
sexual ambiguity is most commonly due to
incomplete external genitalia development at birth
external genitalia complete but opposite of genetic sex
examples are adrenogenital syndrome and androgen insensitivity syndrome
#1 rule for successful sexuality development in cases of ambiguity
do not send ambiguous signals to child
hormonal control of libido in males
androgens from testes increase libido
E or P in large amts can inhibit libido
hormonal control of libido in females
androgen from adrenal (&ovary) increase libido
hormones from ovary may alter libido across the menstrual cycle
E or P in large amts can inhibit libido
androgen increase and libido
increases intensity of sex drive but does not change direction of interest
androgen deprivation and libido
results in incomplete loss of libido
this suggests behavioral conditioning component of libido
pheromones
airborne molecules which act via the olfactory system to influence drives and behaviors
express a physiological/behavioral state to the recipient that yields a response from the recipient
most likely reception pw for pheromones in mammals is via
vomeronasal organ in nasal septa mucosa
pheromones are involved in
social recognition
territorial marking
location mapping
sexual attraction
pheromone chemistry and effects
volatile steroids but no T, E, or P action
present in axillary sweat glands
subtle emotion/mood effects
can advance and retard ovulation
short-chain aliphatic acids that are present in vaginal secretions
pheromones are copulins that
stimulate male libido
have highest production around ovulation
sexuality from a physio perspective
hormonally-determined process of sexual differentiation of the repro system and brain contributes to development of sexuality
hormonal environment in adolescence and adulthood contributes both to development and expression of sexuality
pheromones can enhance sexual attraction and expression of behavior
sexuality and non-physiological factors
there may be genetic predisposition for sexual orientation
social and cultural norms and values affect attitudes and expression of sexuality
species-survival drives imbedded in social and cultural patterns
events of sexual response can be grouped into 3 physio responses
vasocongestion
myotonia
rapid release of A and B due to orgasm
4 stages of sexual response pattern
excitement
plateau
orgasm
resolution
variation in human sexual response
great variation in psychological contributions
little variation in physio events
excitement, plateau, and resolution stages show little sex differences
homologous structures respond similarly
female response patterns may be more varied and are commonly more gradual
frequency of orgasm
refractory period more common in men
multiple orgasms more common in women
orgasm/intercourse ration greater in men
sexual stimuli
senses
memory
mood
context
sexual response cycle operates via
intergration of CNS and genito-pelvic events in a repetitive, summating positive feedback loop that leads to orgasm
this occurs when orgasmic threshold is reached in CNS
massive motor nerve output with focus in genito-pelvic (perineal) region
orgasm
repeated, rhythmic contractions of perineal musculature in response to motor nerve activity described above
CNS cortico-sensory experience of this
testosterone optimizes sensitivity of
CNS substrate regulating libido
CNS components of the summing cycle leading to orgasm
peripheral tissues involved in the sacral reflex
CNS and peripheral events during orgasm
while normally integrated, are not mutually dependent
disorders of sexual function
physical basis- 10-15%
psychological basis- 85-90%
% of patients that have some sexual matter they would like to discuss with their doctor
50%, but <10% actually do so