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8 Cards in this Set
- Front
- Back
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DSM-IV Criteria for Schizophrenia |
DSM-IV classifies symptoms into positive & negative symptoms. Two or more of the symptoms, at least one must be positive and at least one must be negative PLUS significant impairment of general functioning. Symptoms must have all been present during a 1 month period. |
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DSM-IV Positive Symptoms of Schizophrenia |
*Can be visually observed in the patient
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DSM-IV Negative Symptoms of Schizophrenia |
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Schizophrenia Dysregulation Hypothesis |
Psychotic symptoms are due to a lack of control of dopamine, plus other neurotransmitters (GABA, 5-HT, glutamate), with the end result being erratic neurotransmission. (new theory) |
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Dopamine Over-Activity Hypothesis |
Psychotic symptoms result from hyperactivity of dopamine due to increased dopamine concentrations or increased dopamine receptors. (old theory) *Parkinson's Disease drug treatments can cause this exact effect.... |
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Antipsychotics (Neuroleptics) for Schizophrenia |
(New) Atypical Antipsychotics: Quetiapine (Seroquel), Olanzapine (Zyprexa), Clozapine (Clozaril) (Old) Typical Antipsychotics: Chlorpromazine (Thorazine), Haloperidol (Haldol) |
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Typical Antipsychotics Pharmacology |
(Old) Typical Antipsychotics: Blocks various dopamine receptors (DA-1, DA-2, etc.) to varying degrees; strong antagonists
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Atypical Antipsychotics Pharmacology |
(New) Atypical Antipsychotics: Selectively blocks DA-1, DA-4, DA-5 in the limbic system, and selectively binds to the 5-HT and alpha-1 adrenergic blockade. **NO DA-2 blockade = NO EPS effects**
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