• Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

Card Range To Study

through

image

Play button

image

Play button

image

Progress

1/35

Click to flip

Use LEFT and RIGHT arrow keys to navigate between flashcards;

Use UP and DOWN arrow keys to flip the card;

H to show hint;

A reads text to speech;

35 Cards in this Set

  • Front
  • Back
therapeutic consquences of steroids
delayed onset of action
prolonged drug effect
anabolic actions of adrenal steroids
stimulate gluconeogeneis
increase serum glucose
catabolic actions of adrenal steroids
proteins --> AAs
stimulate lipolysis
adrenal steroids and electrolyte balance
impairs calcium absorption
sodium retention and potassium excretion
adrenal steroids and the immune system
decrease infiltration by lymphocytes
inhibit phag. by macs
delayed hypersensitivity rxns
decreases lymph and thymocyte prolif
synthetic corticosteriods vs. those found in body
synthetic have longer half-lives and higher affinities at target tissue receptors
predinsone must be administered this way
orally
actions of cortisol and cortisone
anti-inflammatory and salt-retention
triamcinolone acetonide
very potent topical steroid used to treat asthma
dexamethasone and betamethasone
very potent anti-inflammatory drugs used to treat cerebral edema
seldom used as it is difficult to control
fludrocortisone
very potent salt-retention steriod
adverse effects on cardio and renal systems
salt retention
HTN
edema
hypokalemia
adverse effects on musculoskeletal system and skin
myopathy
osteoporosis
growth retardation in children
prolonged wound healing
adverse effects on eyes and immune system
increased intra-ocular pressure
immunosuppression
metyrapone
inhibits 11-beta-hydroxylation of steroids preventing formation of cortisol and corticosterone
glutethimide
inhibits conversion of cholesterol to 20-alpha-hydroxycholesterol
mifepristone
potent antiglucocorticoid
spirnolactone
antagonist at mineralocorticoid and androgen receptors
eplerenone
aldosterone antagonist
thyroid hormone production steps targeted in drug therapy
blockage of iodide active transport by ionic inhibitors
inhibition of peroxidase by thionamides
iodide trapping and storage of iodiniated thyroglobulin in the thyroid allows for radiation therapy
inhibition of deiodination of T4 to T3
powdered thyroid gland
inexpensive
dosage control difficult
hyperallergenicity
levothyroxine sodium
easily controlled
hypoallergenic
once-daily dosing
liothyronine
chemically pure T3
cardiotoxicity
multiple dosings
liotrix
4:1 ratio of T4:T3
Thionamides
propylthiouracil
methimazole
thionamide MOA
inhibit thyroid peroxidase
prevent iodination of tyrosine on thyroglobulin
block of iodotyrosine coupling
blocks deiodination of T4 to T3
once daily dosing for methimazole because
it accumulates in the thyroid
SEs of thionamides
minor: rashes, fever, vasculitis, arthralgia, jaundice, hepatitis
agranulocytosis can occur (0.5%)
hypothyroidism after prolonged use
thiocyonate and perchlorate
block uptake of iodide
perchlorate use
only as diagnostic agent of thyroid function
Iodide
inhibits T3/4 synthesis and release
decreases size and vascularity of thyroid gland
rapid acting
not suitable for long-term treatment of hyperthyroidism
131-I
only radioactive iodine used for treatment of hyperthyroidism
123-I
diagnosis only
disadvantages of using radioactive Iodine to treat hyperthyroidism
high incidence of delayed hypothyroidism
possible carcinogen
crosses placenta
ophthalmopathy in hyperthyroidism
present in graves disease
not seen in toxic nodular goiter