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34 Cards in this Set
- Front
- Back
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What is the Brand name of Esmolol?
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Brevibloc
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How is Esmolol typically supplied (concentration)?
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10mg/ml
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The usual dose of Esmolol is?
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0.2-0.5mg/kg
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What is the time to onset of Esmolol?
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1-2 mins
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What is the time to peak of Esmolol?
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5 minutes
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What is the duration of Esmolol?
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10-20 mins
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How is Esmolol metabolized?
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In the plasma by Ester hydrolysis
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What receptors does Esmolol act on?
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Beta 1 adrenergic receptor
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What drug class is Esmolol in?
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Beta blocker
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What is the mechanism of action of Esmolol?
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Cardio selective beta 1 antagonist
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What patients would you not give Esmolol to?
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Bradycardia, 2nd or 3rd degree AV block
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What is the Brand name of Hydralazine?
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Apresoline
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How is Hydralazine typically supplied (concentration)?
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20mg/ml
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The usual dose of Hydralazine is?
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2.5-40mg (0.1-0.2 mg/kg)
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What is the time to onset of Hydralazine?
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IV 5- 20 Mins
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What is the time to peak of Hydralazine?
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IV 10-80mins
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What is the duration of Hydralazine?
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2-4 hours ( so be cautious with dosing)
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How is Hydralazine metabolized?
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Hepatic
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What receptors does Hydralazine act on?
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unknown ( Nagelhout)
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What drug class is Hydralazine in?
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Peripheral Vasodilator
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What is the mechanism of action of Hydralazine?
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Direct relaxant effect on arteriolar smooth muscle (interference with Ca Ion transport)
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What patients would you not give Hydralazine to?
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Tachycardiac pt's 2t reflexive tachycardia,
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What is the Brand name of Labetalol?
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Trandate; Normodyne
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How is Labetalol typically supplied (concentration)?
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5 mg/mL (comes in 20 mg Carpuject, 100 mg and 200 mg multi-dose vials)
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The usual dose of Labetalol is?
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20 mg over 2 min. Then 20-80 mg q 10 min until desired BP is achieved. Max 300 mg. Peds:0.4-1 mg/kg/hr IV infusion for HTN crisis
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What is the time to onset of Labetalol?
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2-5 min
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What is the time to peak of Labetalol?
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5-15 min
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What is the duration of Labetalol?
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2-4 hours
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How is Labetalol metabolized?
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Hepatic
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What receptors does Labetalol act on?
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selective alpha-1 and non-selective beta-1 and 2 antagonist
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What drug class is Labetalol in?
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Beta-blocker (mixed alpha/beta adrenergic antagonist)
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What is the mechanism of action of Labetalol?
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Selectively antagonizes alpha-1 adrenergic receptors. Antagonizes beta-1 and 2 receptors
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What patients would you not give Labetalol to?
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Asthma, CHF, any degree of heart block, bradycardia, cardiogenic shock
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What are some clinical uses for Labetalol?
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Pregnancy induced hypertension, hypertensive crisis, and controlled hypotension during anesthesia
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