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11 Cards in this Set
- Front
- Back
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Name three classes of anti-ulcer drugs |
Proton Pump Inhibitors (PPIs), Histamine blockers (H2 blockers), anticholinergics |
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What mediates the protective barrier on the gastric mucosal membrane? |
prostaglandins (PGE2) |
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Which class of drugs blocks protective PGE2? |
NSAIDs |
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When are PPIs used? |
with NSAIDs, prevention/treatment of peptic ulcer disease (PUD), acid reflux (GERD), H. Pylori, hypersecretory conditions |
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How much do PPIs inhibit acid secretion? |
86% |
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Examples of PPIs |
omeprazole (Prilosec), esomeprazole (Nexium), pantoprazole (Protonix), lansoprazole (Prevacid), dexlansoprazole (Dexilant), rabeprazole (Aciphex) |
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What interactions can PPIs cause? |
altered absorption of drugs needing acid pH (calcium, fat soluble vitamins, iron salts, Ketoconazole) |
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What are the adverse effects of PPIs? |
long bone and hip fractures, pneumonia and bacterial infections, hypomagnesemia, rebound hypersecrection |
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Indications for use of H2 blockers |
GERD, stress ulcer prophylaxis |
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Examples of H2 blockers |
ranitidine (Zantac), cimetidine (Tagamet), nizatidine (Axid), famotidine (Pepcid) |
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Which H2 blocker is OTC, but cause many drug reactions? |
cimetidine (Tagamet) |
