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13 Cards in this Set

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  • Back
Schedule I drug
Not approved for medical use--high abuse potential.
ecstasy, LSD, GHB
Schedule II drug
drugs used medically that have high potential for abuse.
*need a new prescription ofr each refill*
opioids, cocaine, methamphetamine, barbituates.
Schedule III drug
Less potential for abuse but still capable of producing addiction + dependence.
androgens, steroids, some CNS stimulants.
Schedule IV drug
some potential for abuse
sedative-hypnotics and some appetite suppressants.
Schedule V drugs
Have moderate amounts of controlled substances in mixture.
*may be given by pharmacist w/out Dr.'s Rx--restrictions on amt., records, etc.*
antidiarrheal drugs
FDA testing: phase 1
few doses to healthy persons
determines toxicity, route, etc.
FDA testing: phase 2
few doses to few ppl w/the disease
--results compared with phase 1--
FDA testing: phase 3
Doses to a larger group of diseased ppl.
Can be double-blind placebo studies or crossover studies.
FDA testing: phase 4
FDA evaluates drug, allows for sale of drug. Post-marketing monitoring begins.
Integral proteins
cell membrane proteins that cross entire membrane--act as pores.
3 pathways of drug movement into cells:
direct penetration of membrane (lipid soluble drugs)
protein channels (only a few drugs--most too large)
carrier proteins (selective transport of drugs by carrier proteins)
What is a major determinant of a drug's bioavailability?
dosage form
(IV = almost 100% available, oral are always <100%)
How do most drugs enter/leave the bloodstream?
by moving through gaps in the capillary membranes.