Ua Pharm Exam #1

Front 1

Schedule I drug

Back 1

Not approved for medical use--high abuse potential.
ecstasy, LSD, GHB

Front 2

Schedule II drug

Back 2

drugs used medically that have high potential for abuse.
*need a new prescription ofr each refill*
opioids, cocaine, methamphetamine, barbituates.

Front 3

Schedule III drug

Back 3

Less potential for abuse but still capable of producing addiction + dependence.
androgens, steroids, some CNS stimulants.

Front 4

Schedule IV drug

Back 4

some potential for abuse
sedative-hypnotics and some appetite suppressants.

Front 5

Schedule V drugs

Back 5

Have moderate amounts of controlled substances in mixture.
*may be given by pharmacist w/out Dr.'s Rx--restrictions on amt., records, etc.*
antidiarrheal drugs

Front 6

FDA testing: phase 1

Back 6

few doses to healthy persons
determines toxicity, route, etc.

Front 7

FDA testing: phase 2

Back 7

few doses to few ppl w/the disease
--results compared with phase 1--

Front 8

FDA testing: phase 3

Back 8

Doses to a larger group of diseased ppl.
Can be double-blind placebo studies or crossover studies.

Front 9

FDA testing: phase 4

Back 9

FDA evaluates drug, allows for sale of drug. Post-marketing monitoring begins.

Front 10

Integral proteins

Back 10

cell membrane proteins that cross entire membrane--act as pores.

Front 11

3 pathways of drug movement into cells:

Back 11

direct penetration of membrane (lipid soluble drugs)
protein channels (only a few drugs--most too large)
carrier proteins (selective transport of drugs by carrier proteins)

Front 12

What is a major determinant of a drug's bioavailability?

Back 12

dosage form
(IV = almost 100% available, oral are always <100%)

Front 13

How do most drugs enter/leave the bloodstream?

Back 13

by moving through gaps in the capillary membranes.