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13 Cards in this Set
- Front
- Back
Schedule I drug
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Not approved for medical use--high abuse potential.
ecstasy, LSD, GHB |
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Schedule II drug
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drugs used medically that have high potential for abuse.
*need a new prescription ofr each refill* opioids, cocaine, methamphetamine, barbituates. |
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Schedule III drug
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Less potential for abuse but still capable of producing addiction + dependence.
androgens, steroids, some CNS stimulants. |
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Schedule IV drug
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some potential for abuse
sedative-hypnotics and some appetite suppressants. |
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Schedule V drugs
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Have moderate amounts of controlled substances in mixture.
*may be given by pharmacist w/out Dr.'s Rx--restrictions on amt., records, etc.* antidiarrheal drugs |
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FDA testing: phase 1
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few doses to healthy persons
determines toxicity, route, etc. |
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FDA testing: phase 2
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few doses to few ppl w/the disease
--results compared with phase 1-- |
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FDA testing: phase 3
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Doses to a larger group of diseased ppl.
Can be double-blind placebo studies or crossover studies. |
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FDA testing: phase 4
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FDA evaluates drug, allows for sale of drug. Post-marketing monitoring begins.
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Integral proteins
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cell membrane proteins that cross entire membrane--act as pores.
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3 pathways of drug movement into cells:
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direct penetration of membrane (lipid soluble drugs)
protein channels (only a few drugs--most too large) carrier proteins (selective transport of drugs by carrier proteins) |
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What is a major determinant of a drug's bioavailability?
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dosage form
(IV = almost 100% available, oral are always <100%) |
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How do most drugs enter/leave the bloodstream?
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by moving through gaps in the capillary membranes.
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