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53 Cards in this Set
- Front
- Back
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major component of adaptive immunity against Giardia
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secretory IgA - eosinophils have nothing to do with protozoan infection (only helminth)
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stimulates naive T cells to become Th1 cells which secrete IFN-gamma
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IL-12
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decreased Th1 cells with decreased IFN-gamma leads to infection by what organism
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mycobacteria (TB)
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what does live attenuated oral vaccine promote more than killed vaccine
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prolonged synthesis and secretion of local mucosal IgA
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forms epitheloid and langhan giant cells seen in TB infection
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macrophages and T lymphocytes
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serum sickness
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type III hypersensitivity which activates complement leading to decreased C3 levels
associated with drug exposure |
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anti-IgE antibodies
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omalizumab
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associated with recurrent infection with bacteria, virus, fungi; failure to thrive and chronic diarrhea
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SCID - B and T cell deficiency
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what does candida skin test guage
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cell-mediated response: CD4, CD8, macrophages, NK cells
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associated with situs inversus, recurrent respiratory infections, and infertility
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abnormal cilia motility - dynein arm dysfunction
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associated with anaphylactic response to tranfused blood pruducts and recurrent sinopulmonary infections
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IgA deficiency
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immune mechanism against influenza
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anti-hemagglutinin IgG and IgA antibodies
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differentiate local and systemic defense against Candida
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local - T cell mediated
systemic - neutrophil mediated |
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contributes to caseous necrosis seen in TB
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IFN-gamma secreted by Th1 cells
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genetic deficiency in CD40 L on T cell
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Hyper IgM
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associated with lymphoid hyperplasia and reuccrent sinopulmonary infections
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Hyper IgM
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Autoimmune reaction from chlamydia, salmonella, shigella, campylobacteri, or yersinia associated with HLA B27
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Reiter syndrome:
arthritis, urethritis, conjunctivitis |
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Th2 cells produces what to stimulate isotype switching to IgE
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IL-4
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which vaccine contains capsular polysaccharide conjugated with diptheriae toxoid
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H. influenzae type B
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this lung disease impairs macrophages leading to increased susceptibility for TB infection
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silicosis
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associated with eczema, recurrent infections, and thrombocytopenia (decreased platelet count)
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Wiscott-Aldrich syndrome
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IgM antibodies against Fc portion of IgG
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rheumatoid factor
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associated with hilar adenopathy, pulmonary infiltrates, and non-caseating granulomas in african american female
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Sarcoidosis
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best way to avoid neonatal tetanus
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give mother tetanus toxoid
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secrete IgA protease to facilitate mucosal penetration
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N. meningitidis
N. gonorrhoeae |
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associated with late separatrion of umbilical cord, absent CD18, poor wound healing, and recurrent skin infections WITHOUT puss formation
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leukocyte adhesion deficiency
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leukocyte adhesion deficiency has absent CD18 leading to what
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inability to synthesis integrins
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positive VDRL in patient with glomerulonephritis, photosensitivity, and arthralgias
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SLE with lupus anticoagulant: causes prolonged PTT and miscarriages
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associated with prolonged PTT and miscarriages
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lupus anticoagulant
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associated with recurrent Neisseria infections
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deficiency in membrane attack complex (C5-9)
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released from mitochondria to activate caspases to induce apoptosis
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cytochrome c
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defect in neutrophil phagosome lymosome fusion leading to giant cytoplasmic granules
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Chediak-Higashi
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associated with immunodeficiency, albinism, and neurologic defects
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Chediak-Higashi
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associated with purpura, abdominal pain, arthralgias, and renal involvement
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Henoch-Schonlein purpura - systemic IgA containing immune complexes
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systemic vasculitis in young male children between 3 and 10 years old
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Henoch-Schonlein purpura
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marker for macrophage
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CD14
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results in increased CD4/CD8 ratio greater than 2:1
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sarcoidosis
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unable to reduce nitroblue tetrazolium because cannot produce ROS due to genetic defect in NADPH oxidase
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chronic granulomatous disease
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generates superoxide by transfering electrons from NADPH
involved within neutrophils |
NADPH oxidase
-deficient in chronic granulomatous disease |
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acute hemolytic tranfusion
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type II hypersensitivity which is antibody-mediated that activate complement within blood vessels
results in dark urine |
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component of each MHC I
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heavy chain and B2-microglobulin
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dendritic cells found in skin conatining Birbeck granules - racquet shaped intracytoplasmic granules
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Langerhans cells
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how do eosinophils destroy parasites
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IgE antibody dependent cytotoxicity
IgE is bound to parasite |
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associated with DNA that is hypersensitive to ionizing radiation due to defect in DNA repair genes
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Ataxia-Telangctasia - cerebellar atrophy and recurrent infections
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killed viral component vaccines generate what response
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humoral response - antibodies
inhibit cell entry |
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mutation of FAS protein prevents what
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apoptosis of auto-reactive lymphocytes
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down-regulate local cytokine production and inflammatory reactions
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IL-10
TGF-B |
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associated with chronic renal rejection
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Tcell and antibody mediated vascular damage (obliterative vascular fibrosis)
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Graft-verses-host disease
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grafted immunocompoenent T cells proliferate in the immunocompromised host and reject cells foreign to them
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associated with vascular fibrinoid necrosis, neutrophil infiltration, and infarction of transplanted kidney
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hyperacute rejection
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associated with HLA B27
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ankylosing spondylitis
reiter syndrome psoriatic arthritis arthritis associated with IBD *seronegative spondyloarthropathies |
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inflammatory disorder of the sacroiliac joint associated with morning stiffness and lower back pain
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ankylosing spondylitis
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why can one get repeated N. gonorrhoeae infections
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high antigenic variability of outer membrane proteins
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