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3 Cards in this Set
- Front
- Back
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Type II Hypersensitivity
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IgG and M
cell mediated cytotoxicity cell associated, antigen is attached to cell 1. activate complement - cell lysis (C5 - 9) 2. phagocytosis - complement and opsinization mediated (C 1-4) 3. activation of NK cells - apoptosis of nucleated cells (ADCC) via granuzymes and perforin |
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Mismatched blood transfusion
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mechanisms: antibody mediated agglutination and lysis of RBC --> uncontrolled bleeding occurs due to disseminated intravascular coagulation (DIC) at the turbulence points
Clinical manifestation: mild: fever and chills severe: acute kidney failure or complete vascular collapse and death |
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Erythroblastosis fetalis
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Mechanism: Anti D and complement mediated damage to RBC
clinical symptoms: - hemolysis leads to increased billirubin --> jaundice and kernicterus (brain disorder) - profound anemia: heart failure, enlarged liver and/or spleen, generalized swelling and respiratory distress, hydrops fetalis (generalized swelling) mother is given antibody to D antigen to prevent this (Roghan) |
