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16 Cards in this Set
- Front
- Back
Drugs Used to Treat Stable Angina Pectoris
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Beta Blockers
Vasodilators -Organic Nitrates (Nitroglycerin) -Calcium Channel Blockers (Verapamil, Amlodipine) Combo Drugs |
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Drugs used during unstable angina pectoris
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Anti-platelet Drugs (Aspirin)
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Drugs used to treat Acute MI
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Fibrinolytics (t-Pa)
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Effects of drugs used to treat stable angina pectoris
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DECREASE CARDIAC WORK
Decrease HR Decrease force of contraction Decrease Preload INCREASE BLOOD FLOW THROUGH CORONARY ARTERIES |
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Use of Vasodilators for Angina Pectoris
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Dilation of veins (decreases preload)
Dilation of coronary arteries (increases O2 to heart muscle) |
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Clinical Usefulness of vasodilators
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1. Dilate the veins
2. Dilate coronary arteries 3. Produce little dilation of aterioles |
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Drugs used to treat variant angina
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Calcium Channel Blockers
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Organic Nitrates
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Nitroglycerin
-Dilate veins and large arteries ALL GIVEN PARENTERALLY due to first pass metabolism |
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Compensatory Responses to Nitrate Drugs
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Vasodilation-->reflecx tachycardia-->increased O2 consumption = may requre combo with beta blocker
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Toxic Effects of Nitrate Drugs
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Headache (Tolerance develops)
Orthostatic Hypotension |
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Mechanism of action of Nitrate Drugs
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Hyperpolarize cells by promoting K+ efflux
Cells are less likely to contract |
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Effects of Non-Cardioselective Calcium Channel Blockers
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Amlodipine
-Block channels in vascular smooth muscle without large effects on cardiac smooth muscle -Vasodilators |
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Effects of Cardioactive Calcium Channel Blockers
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Verapamil
-Block channels in vascular smooth muscle AND cardiac smooth muscle -Vasodilators AND cardiac inhibitors -->Decreased HR, rate of myocardial contraction and force of contraction |
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Potentiall Beneficial Effects of CCBs.
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Arterial Dilation
Cardiac Suppresion |
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When should you use CCBs?
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-For stable angina but only when nitrates or beta blockers are ineffective
-First choice for variant angina -NOT used for unstable angina or acute MI history (less protective against future heart attack) |
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Beta Blockers
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Propranolol
Decreased HR Decreased contractile force Especially useful for Classic Angina -Have been shown to reduce mortality associated with repeated MI and improve exercise tolerance *Combo with organic nitrates |