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16 Cards in this Set

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Drugs Used to Treat Stable Angina Pectoris
Beta Blockers
Vasodilators
-Organic Nitrates (Nitroglycerin)
-Calcium Channel Blockers (Verapamil, Amlodipine)
Combo Drugs
Drugs used during unstable angina pectoris
Anti-platelet Drugs (Aspirin)
Drugs used to treat Acute MI
Fibrinolytics (t-Pa)
Effects of drugs used to treat stable angina pectoris
DECREASE CARDIAC WORK
Decrease HR
Decrease force of contraction
Decrease Preload
INCREASE BLOOD FLOW THROUGH CORONARY ARTERIES
Use of Vasodilators for Angina Pectoris
Dilation of veins (decreases preload)
Dilation of coronary arteries (increases O2 to heart muscle)
Clinical Usefulness of vasodilators
1. Dilate the veins
2. Dilate coronary arteries
3. Produce little dilation of aterioles
Drugs used to treat variant angina
Calcium Channel Blockers
Organic Nitrates
Nitroglycerin
-Dilate veins and large arteries
ALL GIVEN PARENTERALLY due to first pass metabolism
Compensatory Responses to Nitrate Drugs
Vasodilation-->reflecx tachycardia-->increased O2 consumption = may requre combo with beta blocker
Toxic Effects of Nitrate Drugs
Headache (Tolerance develops)
Orthostatic Hypotension
Mechanism of action of Nitrate Drugs
Hyperpolarize cells by promoting K+ efflux
Cells are less likely to contract
Effects of Non-Cardioselective Calcium Channel Blockers
Amlodipine
-Block channels in vascular smooth muscle without large effects on cardiac smooth muscle
-Vasodilators
Effects of Cardioactive Calcium Channel Blockers
Verapamil
-Block channels in vascular smooth muscle AND cardiac smooth muscle
-Vasodilators AND cardiac inhibitors
-->Decreased HR, rate of myocardial contraction and force of contraction
Potentiall Beneficial Effects of CCBs.
Arterial Dilation
Cardiac Suppresion
When should you use CCBs?
-For stable angina but only when nitrates or beta blockers are ineffective
-First choice for variant angina
-NOT used for unstable angina or acute MI history (less protective against future heart attack)
Beta Blockers
Propranolol
Decreased HR
Decreased contractile force
Especially useful for Classic Angina
-Have been shown to reduce mortality associated with repeated MI and improve exercise tolerance
*Combo with organic nitrates