Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
6 Cards in this Set
- Front
- Back
|
APC associated syndromes
|
Familial Adenomatous Polyposis, Gardner Syndrome, Turcot Syndrome
|
|
|
APC features
|
left colon & rectum
usual type colonic adenoca DNA apneuploidy add k-ras, p53 more aggressive biology large number of adenomatous polyps |
|
|
APC adenomatous polyps features
|
Discreet, raised lesion, low grade dysplasia, tubular,
|
|
|
APC gene problem
|
5q
premature truncation between codons 169-1393 5 bp deletion at 1309 |
|
|
Normal APC gene product
|
Tumor supressor gene
Maitains apoptosis interacts with B catenin |
|
|
FAP - timeline
|
20's - polyp
30s -100 polyps 50s - cancer |
