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12 Cards in this Set

  • Front
  • Back
Tumor suppressor genes
loss of function --> cancer
both alleles must be lost for expression of disease
Rb
retinoblastoma
osteosarcoma

rb gene blocks G1-S phase
BRCA1
breast and ovarian cancer

DNA repair protein
BRCA2
breast cancer

DNA repair protein
p53
most human cancer
Li-Fraumeni syndrome --> one allele delation need a second hit

p53 block G1-S phase
p16
Melanoma
APC
Colorectal cancer (associated with FAP)
Gardener (osteoma,lipomas) --> lumpy and bumpy everywhere
Turncots
WT1
Wilm's tumor
NF1
Neurofibramatosis type 1
NF2
Neurofibramatosis type 2 - bilateral acoustic schwannoma
DPC
Pancreatic cancer
DCC
colon cancer