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22 Cards in this Set

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what are the general serum tumor markers?
1. elevated ESR
2. elevated Ldh
3. elevated ferritin
AFP
1. non-seminamatous germ cell tumors of testis
2. primary liver cancers
#1 cause of death from cancer in LDCs
primary liver cell cancer (associated with Hep C)
HCG
1.germ cell tumors
2. placental tumors
3. also epithelial cancer (lung, colon)
glycoprotein serum tumor markers
1. CEA
2. PSA
3. CA125
CEA
1. high levels = GI cancer
2. associated with smoking
CAS125
ovarian cancer
not a good screening test
enzyme tumor markers
1.prostatic acid phosphatase
2. lysozyme
3. histaminase
4. alkaline phosphatase
5. alpha 1 antitrypsin
bradykinin/serotonin
carcinoid syndrome (liver Ca)
immunoglobulin
paraprotein
paraprotein
multiple myeloma
CML
Bcr-Abl (Philadelphia chromosome)
Bcr-Abl where
9:22
what does Bcr-Abl do?
forms a protein with tyrosine kinase activity
neuroblastoma marker?
amplification of n-myc
hep b and c
liver cancer
Hpyl
stomach cancer
streptococcus fecalis
colon cancer
EBV
1. Burkitt's lymphoma
2. nasopharyngeal cancer
HPV
squamous cell carcinomas
pharacogenomics
mRNA expression
useful for predicting efficacy
pharmacogenetics
germline DNA mutations
useful for predicting toxicity