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28 Cards in this Set

  • Front
  • Back
Regulate cell proliferation by suppressing growth
Tumor suppressor genes
Lost in 50% of cancers and positive predictor for metastasis
P53
Antigens that are uniquely found on tumor
Tumor specific
Antigens that are found on both tumors and other cells
Tumor associated
Liver cancer marker, usually not found in healthy adults

Is it tumor specific or tumor associated antigen
AFP

Tumor associated
Indicator of possible colon, pancreatic, breast and lung cancer
CEA --> carcinoembryogenic antigen
Immune system recognizes tumor antigens on cancer cells and destroys them via?
T cell response = tumor surveillance
Cell mediated immune response involves:
NK cells

Cytotoxic T cells

LAK cells (lymphocyte activated killer cells)
MHC type presents on ALL nucleated cells
MHC I
MHC I presents via endogenous or exogenous antigens
Endogenous
Which cells can recognize tumor antigens INDEPENDENT of MHC I
NK cells
Describe recognition of target cells by Tc and NK cells
Tumor cells present "foreign" endogenous tumor antigens on cell surface by MHC I

These are recognized by CD8 cells in conjunction with MHC I

NK cells recognize independently of MHC I
Important mechanism of destruction of single cell cancers (leukemia)
Antibody mediated
Describe ADCC
Antibody binds antigens on the surface of target cells - Fc receptors on NK cells recognize bound antibody --> crosslinking of Fc receptors signals NK cell to kill target cell --> target cells die by apoptosis
What type of cells responsible for ADCC
NK cells
Mechanisms of escaping immune surveillance
Loss of MHC I

Tc cells and NK cells inactivation

Masking of antigens

Antigenic variation

Decoys --> present "dummy" MHC I molecules with antigen
Cutaneous lymphomas - name and what type of cells
Mycosis fungoides and sezary syndrome

Mature T cells
Cancer of plasma cells
Myeloma
Marker for multile myeloma
Bence Jones protein
Bence Jones protein involves which part of protein
Light chain immunoglobulin
Proliferates in immunosuppressed patients stimulates B cell division and often causes c myc translocation
Burkitts lymphoma
CALLA or CD 10 is the marker for _
Common acute lymphoblastic leukemia (not found on normal mature B cells)
Monoclonal antibody from breast cancer - what type
Herceptin - humanized
Monoclonal antibodies from NHL
Rituxan

Zevalin
Monoclonal antibody from AML
Mylotarg
Monoclonal antibody from CLL
Campath
Rituxan (rituximab)- what is it used for and molecular target
NHL, CLL, targets CD20 ( B cells)
Transtuzimab (herceptin) what is it used for and molecular target
Advanced metastatic breast cancer

Mol target her/2neu